M. Amanzio and F. Benedetti, Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems, J Neurosci, vol.19, issue.1, pp.484-494, 1999.

P. M. Aslaksen, M. Bystad, S. M. Vambheim, and M. A. Flaten, Gender differences in placebo analgesia: event-related potentials and emotional modulation, Psychosom Med, vol.73, issue.2, pp.193-199, 2011.

P. M. Aslaksen and M. A. Flaten, The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain, Psychosom Med, vol.70, issue.7, pp.811-818, 2008.

A. J. Barsky, R. Saintfort, M. P. Rogers, and J. F. Borus, Nonspecific medication side effects and the nocebo phenomenon, JAMA, vol.287, issue.5, pp.622-627, 2002.

H. Bartley, K. Faasse, R. Horne, and K. J. Petrie, You Can't Always Get What You Want: The Influence of Choice on Nocebo and Placebo Responding, Ann Behav Med, vol.50, issue.3, pp.445-451, 2016.

H. K. Beecher, The powerful placebo, J Am Med Assoc, vol.159, issue.17, pp.1602-1606, 1955.

F. Benedetti, M. Amanzio, S. Baldi, C. Casadio, and G. Maggi, Inducing placebo respiratory depressant responses in humans via opioid receptors, Eur J Neurosci, vol.11, issue.2, pp.625-631, 1999.

F. Benedetti and S. Dogue, Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials, PLoS One, vol.10, issue.11, p.140967, 2015.

F. Benedetti, A. Pollo, L. Lopiano, M. Lanotte, S. Vighetti et al., , 2003.

, Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses, J Neurosci, vol.23, issue.10, pp.4315-4323

K. C. Berridge and T. E. Robinson, What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?, Brain Res Brain Res Rev, vol.28, issue.3, pp.309-369, 1998.

E. Bjorkedal and M. A. Flaten, Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo, Psychopharmacology (Berl), vol.215, issue.3, pp.537-548, 2011.

B. Blackwell, S. S. Bloomfield, and C. R. Buncher, Demonstration to medical students of placebo responses and non-drug factors, Lancet, vol.1, issue.7763, pp.1279-1282, 1972.

A. Branthwaite and P. Cooper, Analgesic effects of branding in treatment of headaches, Br Med J (Clin Res Ed), vol.282, issue.6276, pp.1576-1578, 1981.

B. E. Butcher and J. J. Carmody, Sex differences in analgesic response to ibuprofen are influenced by expectancy: a randomized, crossover, balanced placebo-designed study, Eur J Pain, vol.16, issue.7, pp.1005-1013, 2012.

C. Carvalho, J. M. Caetano, L. Cunha, P. Rebouta, T. J. Kaptchuk et al., Open-label placebo treatment in chronic low back pain: a randomized controlled trial, Pain, vol.157, issue.12, pp.2766-2772, 2016.

L. Colloca and F. Benedetti, How prior experience shapes placebo analgesia, Pain, vol.124, issue.1-2, pp.126-133, 2006.

L. Colloca, P. Enck, and D. Degrazia, Relieving pain using dose-extending placebos: a scoping review, Pain, vol.157, issue.8, pp.1590-1598, 2016.

L. Colloca, L. Lopiano, M. Lanotte, and F. Benedetti, Overt versus covert treatment for pain, anxiety, and Parkinson's disease, Lancet Neurol, vol.3, issue.11, pp.679-684, 2004.

R. De-la-fuente-fernandez, T. J. Ruth, V. Sossi, M. Schulzer, D. B. Calne et al.,

. Stoessl, Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease, Science, vol.293, issue.5532, pp.1164-1166, 2001.

R. Desharnais, J. Jobin, C. Cote, L. Levesque, and G. Godin, Aerobic exercise and the placebo effect: a controlled study, Psychosom Med, vol.55, issue.2, pp.149-154, 1993.

L. D. Egbert, G. E. Battit, C. E. Welch, and M. K. Bartlett, Reduction of Postoperative Pain by Encouragement and Instruction of Patients. A Study of Doctor-Patient Rapport, N Engl J Med, vol.270, pp.825-827, 1964.

M. Fassler, K. Meissner, A. Schneider, and K. Linde, Frequency and circumstances of placebo use in clinical practice--a systematic review of empirical studies, BMC Med, vol.8, p.15, 2010.

M. A. Flaten, P. M. Aslaksen, A. Finset, T. Simonsen, and O. Johansen, , 2006.

, Cognitive and emotional factors in placebo analgesia, J Psychosom Res, vol.61, issue.1, pp.81-89

S. Freeman, R. Yu, N. Egorova, X. Chen, I. Kirsch et al., Distinct neural representations of placebo and nocebo effects, Neuroimage, vol.112, pp.197-207, 2015.

R. W. Gear, C. Miaskowski, N. C. Gordon, S. M. Paul, P. H. Heller et al., The kappa opioid nalbuphine produces gender-and dose-dependent analgesia and antianalgesia in patients with postoperative pain, Pain, vol.83, issue.2, pp.339-345, 1999.

M. U. Goebel, A. E. Trebst, J. Steiner, Y. F. Xie, M. S. Exton et al.,

M. C. Canbay, U. Michel, M. Heemann, and . Schedlowski, Behavioral conditioning of immunosuppression is possible in humans, FASEB J, vol.16, issue.14, pp.1869-1873, 2002.

M. Gougain, A. Moreau, R. Boussageon, G. Pickering, and F. Gueyffier, , 2017.

, Therapie

R. H. Gracely, R. Dubner, W. R. Deeter, and P. J. Wolskee, Clinicians' expectations influence placebo analgesia, Lancet, vol.1, issue.8419, p.43, 1985.

H. Haas, H. Fink, and G. Haertfelder, Fortschritte der Arzneimittelforschung, vol.1, pp.279-454, 1959.

J. C. Horvitz, Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events, Neuroscience, vol.96, issue.4, pp.651-656, 2000.

J. Howick, F. L. Bishop, C. Heneghan, J. Wolstenholme, S. Stevens et al., Placebo use in the United kingdom: results from a national survey of primary care practitioners, PLoS One, vol.8, issue.3, p.58247, 2013.

T. J. Kaptchuk, E. Friedlander, J. M. Kelley, M. N. Sanchez, E. Kokkotou et al.,

M. Singer, F. G. Kowalczykowski, I. Miller, A. J. Kirsch, and . Lembo, Placebos without deception: a randomized controlled trial in irritable bowel syndrome, PLoS One, vol.5, issue.12, p.15591, 2010.

T. J. Kaptchuk, J. M. Kelley, L. A. Conboy, R. B. Davis, C. E. Kerr et al., Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome, BMJ, vol.336, issue.7651, pp.999-1003, 2008.

I. Kirsch and L. J. Weixel, Double-blind versus deceptive administration of a placebo, Behav Neurosci, vol.102, issue.2, pp.319-323, 1988.

J. D. Levine, N. C. Gordon, and H. L. Fields, The mechanism of placebo analgesia, Lancet, vol.2, issue.8091, pp.654-657, 1978.

J. J. Lipman, B. E. Miller, K. S. Mays, M. N. Miller, W. C. North et al., Peak B endorphin concentration in cerebrospinal fluid: reduced in chronic pain patients and increased during the placebo response, Psychopharmacology (Berl), vol.102, issue.1, pp.112-116, 1990.

G. C. Machado, C. G. Maher, P. H. Ferreira, M. B. Pinheiro, C. W. Lin et al., Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials, BMJ, vol.350, p.1225, 2015.

A. B. Overgaard, J. Hojsted, R. Hansen, J. Moller-sonnergaard, and L. L. Christrup, Patients' evaluation of shape, size and colour of solid dosage forms, Pharm World Sci, vol.23, issue.5, pp.185-188, 2001.

P. Petrovic, E. Kalso, K. M. Petersson, and M. Ingvar, Placebo and opioid analgesia--imaging a shared neuronal network, Science, vol.295, issue.5560, pp.1737-1740, 2002.

A. Pollo, S. Vighetti, I. Rainero, and F. Benedetti, Placebo analgesia and the heart, Pain, vol.102, issue.1-2, pp.125-133, 2003.

B. T. Saragiotto, G. C. Machado, M. L. Ferreira, M. B. Pinheiro, C. Shaheed et al., Paracetamol for low back pain, Cochrane Database Syst Rev, issue.6, p.12230, 2016.

A. K. Shapiro and E. Shapiro, The powerful placebo: from ancient priest to modern physician, BMJ, vol.316, issue.7141, p.1396, 1998.

K. B. Thomas, General practice consultations: is there any point in being positive?, Br Med J (Clin Res Ed), vol.294, issue.6581, pp.1200-1202, 1987.

E. M. Unterwald, Regulation of opioid receptors by cocaine, Ann N Y Acad Sci, vol.937, pp.74-92, 2001.

N. D. Volkow, J. S. Fowler, G. J. Wang, and J. M. Swanson, Dopamine in drug abuse and addiction: results from imaging studies and treatment implications, Mol Psychiatry, vol.9, issue.6, pp.557-569, 2004.

R. L. Waber, B. Shiv, Z. Carmon, and D. Ariely, Commercial features of placebo and therapeutic efficacy, JAMA, vol.299, issue.9, pp.1016-1017, 2008.

B. T. Walsh, S. N. Seidman, R. Sysko, and M. Gould, Placebo response in studies of major depression: variable, substantial, and growing, JAMA, vol.287, issue.14, pp.1840-1847, 2002.

M. J. Will, E. B. Franzblau, and A. E. Kelley, Nucleus accumbens mu-opioids regulate intake of a high-fat diet via activation of a distributed brain network, J Neurosci, vol.23, issue.7, pp.2882-2888, 2003.

C. M. Williams, J. Latimer, C. G. Maher, A. J. Mclachlan, C. W. Cooper et al.,

R. O. Hancock, J. H. Day, C. W. Mcauley, and . Lin, PACE--the first placebo controlled trial of paracetamol for acute low back pain: design of a randomised controlled trial, BMC Musculoskelet Disord, vol.11, p.169, 2010.

W. Zhang, G. Nuki, R. W. Moskowitz, S. Abramson, R. D. Altman et al.,

K. D. Bierma-zeinstra, P. Brandt, M. Croft, M. Doherty, M. Dougados et al., OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update, Osteoarthritis Cartilage, vol.18, issue.4, pp.476-499, 2009.

J. K. Zubieta, J. A. Bueller, L. R. Jackson, D. J. Scott, Y. Xu et al., Placebo effects mediated by endogenous opioid activity on mu-opioid receptors, J Neurosci, vol.25, issue.34, pp.7754-7762, 2005.

J. K. Zubieta, T. A. Ketter, J. A. Bueller, Y. Xu, M. R. Kilbourn et al.,

A. Koeppe, Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission, Arch Gen Psychiatry, vol.60, issue.11, pp.1145-1153, 2003.

J. J. Aulas, « Des illusions qui guérissent, p.54, 1993.

R. Burton, « The Anatomy of Melancholy », Empire State Book Co, p.168, 1628.

C. Bykov, « L'écorce cérébrale et les organes internes » Editions en langues étrangères, Moscou, p.534, 1956.

, « Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research » Institute of Medicine, Committee on Advancing Pain Research, Care, and Education, 2011.

I. O. Godfroid, « Placebo I -L'effet placebo : une gifle à la science ?, Ann Méd-Psychol, vol.155, issue.7, pp.436-443, 1997.

P. Lemoine, « Le mystère du placebo, p.146, 1996.

M. Montaigne, « Essais », tome I, Livre premier, Chap. XX Thèses 60) PANIER Raphaël, « De l'acceptabilité éthique et pratique à l'usage de la placebo-thérapie en médecine générale à Bruxelles, 1580.

. Sixou-pierre, Vers un outil de mesure de la confiance du patient envers son médecin généraliste. Validation de l'adaptation culturelle française d l'échelle de confiance de Wake Forest, 2016.

, Bases de données

, Etudes et résultats n°315 Les consultations et visites de médecins généralistes

L. Paracétamol, D. Cnrd, and . Sur,

, Analyse des ventes de médicaments en France, Ipsos Sanofi Zentiva, 2013.

;. Atlas-de-la-démographie-médicale-en-france, D. Oms, ;. Insee, and D. Sur, 69) Situation démographique en Ile de France, Conseil National de l'Ordre des médecins, 2016.

, Textes officiels

, -303 du 4 mars 2002 relative aux droits des malades et à la qualité du système de santé, 2002.

, Echelle de confiance de Wake Forest, version française Après avoir lu chaque proposition, Annexe, vol.4

, Votre médecin mettra tout en oeuvre pour vous soigner

, Analyse multivariée en régression logistique avec la part perçue d'effet placebo comme variable catégorielle dichotomisée par sa médiane, Annexe, vol.10