«. Ainsi, Tongue Care+ » était significativement plus efficace que les deux autres moyens de traitement jusqu'à 8 heures et 8 heures après une semaine d'utilisation

, Il existe toutefois des limites à ces études notamment en rapport avec l'interprétation des résultats. Les études citées sont toutes menées et sponsorisées par la firme industrielle Philips

, On peut également relever dans les études que le groupe qui bénéficie du dispositif « TongueCare + » profite de l'effet « Hawthorne » du produit. Les sujets ont conscience de participer à une expérience dans laquelle ils sont testés, ce qui se traduit généralement par une plus grande motivation

, De plus, les résultats des études ne sont qu'à court terme (quelques heures à chaque fois)

E. A. Akaji, N. Folaranmi, and O. Ashiwaju, Halitosis: a review of the literature on its prevalence, impact and control. Oral Health Prev Dent, vol.12, pp.297-304, 2014.

T. Amou, D. Hinode, M. Yoshioka, and D. Grenier, Relationship between halitosis and periodontal diseaseassociated oral bacteria in tongue coatings, Int J Dent Hyg, vol.12, issue.2, p.51, 2014.

A. D. Apatzidou, E. Bakirtzoglou, I. Vouros, V. Karagiannis, A. Papa et al., Association between oral malodour and periodontal disease-related parameters in the general population, Acta Odontol Scand, vol.71, issue.1, pp.189-95, 2013.

P. Axelsson, B. Nyström, and J. Lindhe, The long-term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults. Results after 30 years of maintenance, J Clin Periodontol, vol.31, issue.9, pp.749-57, 2004.

C. Azodo, N. Osazuwa-peters, and M. Omili, Psychological and social impact of halitosis : A review, J Soc Psycho Sci, vol.3, pp.74-91, 2010.

J. Betsy, C. S. Prasanth, K. V. Baiju, J. Prasanthila, and N. Subhash, Efficacy of antimicrobial photodynamic therapy in the management of chronic periodontitis: a randomized controlled clinical trial, J Clin Periodontol, vol.41, issue.6, p.81, 2014.

D. M. Brunette, H. M. Proskin, and B. J. Nelson, The effects of dentifrice systems on oral malodor, J Clin Dent, 1998.

M. D. Carvalho, C. M. Tabchoury, J. A. Cury, S. Toledo, and G. R. Nogueira-filho, Impact of mouthrinses on morning bad breath in healthy subjects, J Clin Periodontol, vol.31, issue.2, p.90, 2004.

J. Dadamio, M. Van-tournout, W. Teughels, C. Dekeyser, W. Coucke et al., Efficacy of different mouthrinse formulations in reducing oral malodour: a randomized clinical trial, J Clin Periodontol, vol.40, issue.5, pp.505-518, 2013.

D. Boever, E. H. Loesche, and W. J. , Assessing the contribution of anaerobic microflora of the tongue to oral malodor, J Am Dent Assoc, vol.126, issue.10, pp.1384-93, 1939.

S. De-geest, I. Laleman, W. Teughels, C. Dekeyser, and M. Quirynen, Periodontal diseases as a source of halitosis: a review of the evidence and treatment approaches for dentists and dental hygienists, Periodontol, vol.71, issue.1, pp.213-240, 2000.

E. Ademovski, S. Lingström, P. Winkel, E. Tangerman, A. Persson et al., Comparison of different treatment modalities for oral halitosis, Acta Odontol Scand, vol.70, issue.3, p.33, 2012.

S. Erovic-ademovski, C. Mårtensson, G. R. Persson, and S. Renvert, The effect of periodontal therapy on intraoral halitosis: a case series, J Clin Periodontol, vol.43, issue.5, pp.445-52, 2016.

C. M. Faggion, N. P. Bakas, and J. Wasiak, A survey of prevalence of narrative and systematic reviews in five major medical journals, BMC Med Res Methodol, vol.28, issue.1, p.176, 2017.

X. Feng, X. Chen, R. Cheng, L. Sun, Y. Zhang et al., Breath malodor reduction with use of a stannouscontaining sodium fluoride dentifrice: a meta-analysis of four randomized and controlled clinical trials, Am J Dent, vol.23, pp.27-31, 2010.

M. Feres, L. C. Figueiredo, M. Faveri, M. C. Guerra, L. R. Mateo et al., The efficacy of two oral hygiene regimens in reducing oral malodour: a randomised clinical trial, Int Dent J, vol.65, issue.6, p.302, 2015.

C. Fujimoto, H. Maeda, S. Kokeguchi, S. Takashiba, F. Nishimura et al., Application of denaturing gradient gel electrophoresis (DGGE) to the analysis of microbial communities of subgingival plaque, J Periodontal Res, vol.38, issue.4, pp.440-445, 2003.

S. Huang, F. Yang, X. Zeng, J. Chen, R. Li et al., Preliminary characterization of the oral microbiota of Chinese adults with and without gingivitis, BMC Oral Health, vol.11, p.33, 2011.

M. Huchet, Halitose et maladies parodontales, 2009.

A. Iatropoulos, V. Panis, M. E. Stefaniotis, T. Madianos, P. N. Papaioannou et al., Changes of volatile sulphur compounds during therapy of a case series of patients with chronic periodontitis and halitosis, J Clin Periodontol, vol.43, issue.4, pp.359-65, 2016.

C. Kara, T. Demir, R. Orbak, and A. Tezel, Effect of Nd: YAG laser irradiation on the treatment of oral malodour associated with chronic periodontitis, Int Dent J, vol.58, issue.3, pp.151-159, 2008.

C. Kara, A. Tezel, and R. Orbak, Effect of oral hygiene instruction and scaling on oral malodour in a population of Turkish children with gingival inflammation, Int J Paediatr Dent, vol.16, issue.6, pp.399-404, 2006.

M. Kilian, I. Chapple, M. Hannig, P. D. Marsh, V. Meuric et al., The oral microbiomean update for oral healthcare professionals, Br Dent J, vol.221, issue.10, pp.657-66, 2016.

S. Koshimune, S. Awano, K. Gohara, E. Kurihara, T. Ansai et al., Low salivary flow and volatile sulfur compounds in mouth air. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, vol.96, p.41, 2003.

P. S. Kumar, E. J. Leys, J. M. Bryk, F. J. Martinez, M. L. Moeschberger et al., Changes in periodontal health status are associated with bacterial community shifts as assessed by quantitative 16S cloning and sequencing, J Clin Microbiol, vol.44, issue.10, pp.3665-73, 2006.

G. S. Madhushankari, A. Yamunadevi, M. Selvamani, M. Kumar, K. P. Basandi et al., Halitosis -An overview: Part-I -Classification, etiology, and pathophysiology of halitosis, J Pharm Bioallied Sci, vol.7, issue.2, pp.339-343, 2015.

J. P. Meningaud, F. Bado, E. Favre, J. C. Bertrand, and F. Guilbert,

, Rev Stomatol Chir Maxillofac, vol.100, issue.5, pp.240-244, 1999.

J. Meyle and I. Chapple, Molecular aspects of the pathogenesis of periodontitis, Periodontol, 2000.

H. Miyazaki, S. Sakao, Y. Katoh, and T. Takehara, Correlation between volatile sulphur compounds and certain oral health measurements in the general population, J Periodontol, vol.66, issue.8, pp.679-84, 1995.

J. M. Oliveira-neto, S. Sato, and V. Pedrazzi, How to deal with morning bad breath: A randomized, crossover clinical trial, J Indian Soc Periodontol, vol.17, issue.6, p.61, 2013.

T. L. Outhouse, R. Al-alawi, Z. Fedorowicz, and J. V. Keenan, WITHDRAWN: Tongue scraping for treating halitosis, Cochrane Database Syst Rev, issue.5, p.5519, 2016.

O. Park, H. Yi, J. H. Jeon, S. Kang, K. Kum et al., Pyrosequencing Analysis of Subgingival Microbiota in Distinct Periodontal Conditions, J Dent Res, vol.94, issue.7, pp.921-928, 2015.

V. Pedrazzi, C. Do-nascimento, M. Issa, J. P. Fedorowicz, and Z. , Interventions for managing halitosis

, Cochrane Database Syst Rev, p.14, 2016.

. Cd012213.-disponible and . Sur,

V. Pedrazzi, S. Sato, G. C. De-mattos-m-da, E. Lara, and H. Panzeri, Tongue-cleaning methods: a comparative clinical trial employing a toothbrush and a tongue scraper, J Periodontol, vol.75, issue.7, pp.1009-1021, 2004.

S. Penala, B. Kalakonda, K. R. Pathakota, A. Jayakumar, P. Koppolu et al., Efficacy of local use of probiotics as an adjunct to scaling and root planing in chronic periodontitis and halitosis: A randomized controlled trial, J Res Pharm Pract, vol.5, issue.2, p.93, 2016.

S. Persson, M. B. Edlund, R. Claesson, and J. Carlsson, The formation of hydrogen sulfide and methyl mercaptan by oral bacteria, Oral Microbiol Immunol, vol.5, issue.4, 1990.

. Pham-t-a.-v, M. Ueno, T. Zaitsu, S. Takehara, K. Shinada et al., Clinical trial of oral malodor treatment in patients with periodontal diseases, J Periodontal Res, vol.46, issue.6, p.9, 2011.

M. Quirynen, P. Avontroodt, C. Soers, H. Zhao, M. Pauwels et al., The efficacy of amine fluoride/stannous fluoride in the suppression of morning breath odour, J Clin Periodontol, vol.29, issue.10, pp.944-54, 2002.

M. Quirynen, P. Avontroodt, C. Soers, H. Zhao, M. Pauwels et al., Impact of tongue cleansers on microbial load and taste, J Clin Periodontol, vol.31, issue.7, p.10, 2004.

M. Quirynen, J. Dadamio, S. Van-den-velde, D. Smit, M. Dekeyser et al., Characteristics of 2000 patients who visited a halitosis clinic, J Clin Periodontol, vol.36, issue.11, pp.970-975, 2009.

M. Quirynen, C. Mongardini, and D. Van-steenberghe, The effect of a 1-stage full-mouth disinfection on oral malodor and microbial colonization of the tongue in periodontitis. A pilot study, J Periodontol, vol.69, issue.3, p.82, 1998.

M. Quirynen, H. Zhao, C. Soers, C. Dekeyser, M. Pauwels et al., The impact of periodontal therapy and the adjunctive effect of antiseptics on breath odor-related outcome variables: a double-blind randomized study, J Periodontol, vol.76, issue.5, pp.705-717, 2005.

P. A. Ratcliff and P. W. Johnson, The relationship between oral malodor, gingivitis, and periodontitis. A review, J Periodontol, vol.70, issue.5, pp.485-494, 1999.

S. Rayman and K. Almas, Halitosis among racially diverse populations: an update, Int J Dent Hyg, 2008.

W. Ren, Z. Xun, Z. Wang, Q. Zhang, X. Liu et al., Tongue Coating and the Salivary Microbial Communities Vary in Children with, Halitosis. Sci Rep, vol.6, p.24481, 2016.

W. Ren, Q. Zhang, X. Liu, S. Zheng, L. Ma et al., Supragingival Plaque Microbial Community Analysis of Children with Halitosis, J Microbiol Biotechnol, 2016.

M. Rosenberg, I. Gelernter, M. Barki, and R. Bar-ness, Day-long reduction of oral malodor by a two-phase oil:water mouthrinse as compared to chlorhexidine and placebo rinses, J Periodontol, vol.63, issue.1, pp.39-43, 1992.

J. L. Round and S. K. Mazmanian, The gut microbiome shapes intestinal immune responses during health and disease, Nat Rev Immunol, vol.9, issue.5, pp.313-336, 2009.

S. Saad, P. Gomez-pereira, K. Hewett, P. Horstman, J. Patel et al., Daily reduction of oral malodor with the use of a sonic tongue brush combined with an antibacterial tongue spray in a randomized crossover clinical investigation, J Breath Res, vol.10, issue.1, p.16013, 2016.

M. Sanz, S. Roldán, and D. Herrera, Fundamentals of breath malodour, J Contemp Dent Pract

H. E. Schroeder, S. Münzel-pedrazzoli, and R. Page, Correlated morphometric and biochemical analysis of gingival tissue in early chronic gingivitis in man, Arch Oral Biol, vol.18, issue.7, p.923, 1973.

N. C. Sharma, H. J. Galustians, J. Qaqish, A. Galustians, K. Rustogi et al., Clinical effectiveness of a dentifrice containing triclosan and a copolymer for controlling breath odor, Am J Dent, vol.20, issue.2, pp.79-82, 2007.

J. F. Siqueira, I. N. Rôças, S. Paiva, K. M. Magalhães, and T. Guimarães-pinto, Cultivable bacteria in infected root canals as identified by 16S rRNA gene sequencing, Oral Microbiol Immunol, vol.22, issue.4, p.71, 2007.

D. E. Slot, D. Geest, S. Van-der-weijden, F. A. Quirynen, and M. , Treatment of oral malodour. Medium-term efficacy of mechanical and/or chemical agents: a systematic review, J Clin Periodontol, vol.42, pp.303-316, 2015.

S. S. Socransky, A. D. Haffajee, M. A. Cugini, C. Smith, and R. L. Kent, Microbial complexes in subgingival plaque, J Clin Periodontol, vol.25, issue.2, p.44, 1998.

I. F. Spellerberg and P. J. Fedor, A tribute to Claude Shannon (1916-2001) and a plea for more rigorous use of species richness, species diversity and the 'Shannon-Wiener' Index, Glob Ecol Biogeogr, vol.12, issue.3, pp.177-186, 2003.

F. L. Suarez, J. K. Furne, J. Springfield, and M. D. Levitt, Morning breath odor: influence of treatments on sulfur gases, J Dent Res, vol.79, issue.10, pp.1773-1780, 2000.

T. Takeshita, N. Suzuki, Y. Nakano, M. Yasui, M. Yoneda et al., Discrimination of the oral microbiota associated with high hydrogen sulfide and methyl mercaptan production, Sci Rep, vol.2, p.215, 2012.

M. Tanaka, Y. Yamamoto, M. Kuboniwa, A. Nonaka, N. Nishida et al., Contribution of periodontal pathogens on tongue dorsa analyzed with real-time PCR to oral malodor, Microbes Infect, vol.6, issue.12, pp.1078-83, 2004.

J. Tonzetich and S. K. Ng, Reduction of malodor by oral cleansing procedures. Oral Surg Oral Med Oral Pathol, vol.42, p.81, 1976.

A. P. Vieira-colombo, C. B. Magalhães, F. Hartenbach, R. Martins-do-souto, M. Da-silva-boghossian et al., Periodontal-disease-associated biofilm: A reservoir for pathogens of medical importance, Microb Pathog, vol.94, pp.27-34, 2016.

S. M. Wåler, The effect of zinc-containing chewing gum on volatile sulfur-containing compounds in the oral cavity, Acta Odontol Scand, vol.55, issue.3, 1997.

K. Yaegaki, W. Qian, T. Murata, T. Imai, T. Sato et al., Oral malodorous compound causes apoptosis and genomic DNA damage in human gingival fibroblasts, J Periodontal Res

K. Yaegaki and K. Sanada, Volatile sulfur compounds in mouth air from clinically healthy subjects and patients with periodontal disease, J Periodontal Res, vol.27, issue.4, pp.233-241, 1992.

G. Yamina, A. Ayat, H. Lazili, and B. Saari, Halitose: origine, classification et traitement, Int Arab J Dent, vol.5, issue.2, pp.75-83, 2014.

F. Yang, S. Huang, T. He, C. Catrenich, F. Teng et al., Microbial basis of oral malodor development in humans, J Dent Res, vol.92, issue.12, pp.1106-1118, 2013.

A. Zürcher, A. Filippi, and . Findings, diagnoses and results of a halitosis clinic over a seven year period, Schweiz Monatsschrift Zahnmed Rev Mens Suisse Odonto-Stomatol Riv Mens Svizzera Odontol E Stomatol, vol.122, issue.3, pp.205-221, 2012.