P. Demoly, Safety of intranasal corticosteroids in acute rhinosinusitis, Am J Otolaryngol. déc, vol.29, issue.6, pp.403-416, 2008.

J. Sastre and R. Mosges, Local and systemic safety of intranasal corticosteroids, J Investig Allergol Clin Immunol, vol.22, issue.1, pp.1-12, 2012.

T. Rhen and J. A. Cidlowski, Antiinflammatory action of glucocorticoids--new mechanisms for old drugs

, N Engl J Med, vol.353, issue.16, pp.1711-1734, 2005.

V. J. Lund, J. Flood, A. P. Sykes, and D. H. Richards, Effect of fluticasone in severe polyposis, Arch Otolaryngol Head Neck Surg. mai, vol.124, issue.5, pp.513-521, 1998.

C. B. Small, J. Hernandez, A. Reyes, E. Schenkel, A. Damiano et al., Efficacy and safety of mometasone furoate nasal spray in nasal polyposis, J Allergy Clin Immunol. déc, vol.116, issue.6, pp.1275-81, 2005.

L. Y. Chong, K. Head, C. Hopkins, C. Philpott, A. G. Schilder et al., Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis. Cochrane ENT Group, éditeur. Cochrane Database Syst Rev, vol.26

D. Sur,

J. Bousquet, P. Van-cauwenberge, and N. Khaltaev,

, Allergic rhinitis and its impact on asthma, J Allergy Clin Immunol, vol.108, issue.5, pp.147-334, 2001.

, ANSM -Bonnes pratiques de pharmacovigilance -février, 2018.

, Pharmacovigilance: assurer la sécurité d'emploi des médicaments -Perspectives politiques de l'OMS sur les médicaments, No. 09 octobre 2004: Programme OMS de pharmacovigilance internationale

D. Sur,

L. Y. Chong, K. Head, C. Hopkins, C. Philpott, M. J. Burton et al., Different types of intranasal steroids for chronic rhinosinusitis. Cochrane ENT Group, éditeur. Cochrane Database Syst Rev

D. Sur,

M. S. Blaiss, Safety considerations of intranasal corticosteroids for the treatment of allergic rhinitis

, Allergy Asthma Proc. avr, vol.28, issue.2, pp.145-52, 2007.

S. J. Szefler, Pharmacokinetics of intranasal corticosteroids, J Allergy Clin Immunol. juill, vol.108, issue.1, 2001.

M. S. Blaiss, Safety update regarding intranasal corticosteroids for the treatment of allergic rhinitis

, Allergy Asthma Proc. déc, vol.32, issue.6, pp.413-421, 2011.

H. Derendorf and E. O. Meltzer, Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications, Allergy, vol.63, issue.10, pp.1292-300, 2008.

B. J. Lipworth and C. M. Jackson, Safety of inhaled and intranasal corticosteroids: lessons for the new millennium, Drug Saf. juill, vol.23, issue.1, pp.11-33, 2000.

R. Gupta and L. S. Fonacier, Adverse Effects of Nonsystemic Steroids (Inhaled

, a Review of the Literature and Suggested Monitoring Tool. Curr Allergy Asthma Rep, vol.16, 2016.

D. B. Allen, Systemic effects of intranasal steroids: an endocrinologist's perspective, J Allergy Clin Immunol, vol.106, issue.4, pp.179-190, 2000.

G. Scadding, A. N. Erkan, H. Chau, and S. Maskell, Audit of nasal steroid use and effectiveness in a rhinitis clinic, Expert Rev Pharmacoecon Outcomes Res. févr, vol.10, issue.1, pp.87-90, 2010.

M. S. Benninger, J. A. Hadley, J. D. Osguthorpe, B. F. Marple, D. A. Leopold et al., Techniques of intranasal steroid use. Otolaryngol--Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg, janv, vol.130, issue.1, pp.5-24, 2004.

A. V. Raveendran, Inhalational Steroids and Iatrogenic Cushing's Syndrome, Open Respir Med J. 31 janv, vol.8, pp.74-84, 2014.

G. Arnaldi, G. Tirabassi, R. Papa, G. Furlani, L. Trementino et al., Human corticotropin releasing hormone test performance in the differential diagnosis between Cushing's disease and pseudo-Cushing state is enhanced by combined ACTH and cortisol analysis, Eur J Endocrinol. juin, vol.160, issue.6, pp.891-899, 2009.

A. M. Wilson, E. J. Sims, L. C. Mcfarlane, and B. J. Lipworth, Effects of intranasal corticosteroids on adrenal, bone, and blood markers of systemic activity in allergic rhinitis, J Allergy Clin Immunol, vol.102, issue.4, pp.598-604, 1998.

D. P. Skoner, G. S. Rachelefsky, E. O. Meltzer, P. Chervinsky, R. M. Morris et al., Detection of growth suppression in children during treatment with intranasal beclomethasone dipropionate, Pediatrics. févr, vol.105, issue.2, p.23, 2000.

N. Ahmadi, K. Snidvongs, L. Kalish, R. Sacks, K. Tumuluri et al., Intranasal corticosteroids do not affect intraocular pressure or lens opacity: a systematic review of controlled trials, Rhinology. déc, vol.53, issue.4, pp.290-302, 2015.

L. Derby and W. C. Maier, Risk of cataract among users of intranasal corticosteroids, J Allergy Clin Immunol. mai, vol.105, issue.5, pp.912-918, 2000.

K. Sheth, Evaluating the Safety of Intranasal Steroids in the Treatment of Allergic Rhinitis, Allergy Asthma Clin Immunol, vol.4, issue.3, p.125, 2008.

R. J. Salib and P. H. Howarth, Safety and tolerability profiles of intranasal antihistamines and intranasal corticosteroids in the treatment of allergic rhinitis, Drug Saf, vol.26, issue.12, pp.863-93, 2003.

C. Gilbert, P. Mazzotta, R. Loebstein, and G. Koren, Fetal safety of drugs used in the treatment of allergic rhinitis: a critical review, Drug Saf, vol.28, issue.8, pp.707-726, 2005.

A. Bérard, O. Sheehy, M. Kurzinger, and J. Juhaeri, Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes, J Allergy Clin Immunol. juill, vol.138, issue.1, pp.97-104, 2016.

P. B. Danielson, The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans, Curr Drug Metab. déc, vol.3, issue.6, pp.561-97, 2002.

A. Daveluy, C. Raignoux, G. Miremont-salamé, P. Girodet, N. Moore et al., Drug interactions between inhaled corticosteroids and enzymatic inhibitors, Eur J Clin Pharmacol. juill, vol.65, issue.7, pp.743-748, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00534957

V. R. Tandon, V. Mahajan, V. Khajuria, and Z. Gillani, Under-reporting of adverse drug reactions: A challenge for pharmacovigilance in India, Indian J Pharmacol, vol.47, issue.1, pp.65-71, 2015.

, Annexe 1 : Mécanismes d'absorption des corticostéroïdes nasaux (17)

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