. .. Résumé-en-français,

. .. Résumé-en-anglais,

.. .. Revue-de-la-littérature,

, Contributions

.. .. Statut,

. .. Manuscrit,

M. Delebarre, A. Tiphaine, A. Martinot, F. Dubos, and . Al, Risk-stratification management of febrile neutropenia in pediatric hematology-oncology patients: Results of a French nationwide survey, Pediatr Blood Cancer, vol.63, issue.12, pp.2167-2172, 2016.

G. M. Haeusler, F. Mechinaud, and A. J. Daley, Antibiotic-resistant Gram-negative bacteremia in pediatric oncology patients--risk factors and outcomes, Pediatr Infect Dis J, vol.32, issue.7, pp.723-726, 2013.

A. Simon, R. Furtwängler, and N. Graf, Surveillance of bloodstream infections in pediatric cancer centers -what have we learned and how do we move on?, GMS Hyg Infect Control, vol.11, p.11, 2016.

R. A. Ammann, H. J. Laws, and D. Schrey, Bloodstream infection in paediatric cancer centres--leukaemia and relapsed malignancies are independent risk factors, Eur J Pediatr, vol.174, issue.5, pp.675-686, 2015.

I. Hann, C. Viscoli, M. Paesmans, H. Gaya, and M. Glauser, A comparison of outcome from febrile neutropenic episodes in children compared with adults: results from four EORTC studies. International Antimicrobial Therapy Cooperative Group (IATCG) of the European Organization for Research and Treatment of Cancer (EORTC), Br J Haematol, vol.99, issue.3, pp.580-588, 1997.

C. Domenech, C. Leick-courtois, and A. Bienvenu, Improvement in the Outcome of Invasive Aspergillosis in a Pediatric Hematology Department: A 10-Year Review, J Pediatr Hematol Oncol, vol.37, issue.7, pp.560-565, 2015.

A. J. Zimmer and A. G. Freifeld, Optimal Management of Neutropenic Fever in Patients With Cancer, J Oncol Pract, vol.15, issue.1, pp.19-24, 2019.

N. Thacker, N. Pereira, and S. D. Banavali, Epidemiology of blood stream infections in pediatric patients at a Tertiary Care Cancer Centre, Indian J Cancer, vol.51, issue.4, pp.438-441, 2014.

K. Miedema, R. Winter, and R. A. Ammann, Bacteria causing bacteremia in pediatric cancer patients presenting with febrile neutropenia--species distribution and susceptibility patterns. Support Care Cancer Off J Multinatl Assoc Support Care Cancer, vol.21, pp.2417-2426, 2013.

T. Lehrnbecher, P. Robinson, and B. Fisher, Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update, J Clin Oncol Off J Am Soc Clin Oncol, vol.35, issue.18, pp.2082-2094, 2017.

K. Miedema, R. Winter, R. A. Ammann, S. Droz, L. Spanjaard et al., Bacteria causing bacteremia in pediatric cancer patients presenting with febrile neutropenia--species distribution and susceptibility patterns. Support Care Cancer Off J Multinatl Assoc Support Care Cancer, vol.21, pp.2417-2443, 2013.

M. Delebarre, A. Tiphaine, A. Martinot, and F. Dubos, Risk-stratification management of febrile neutropenia in pediatric hematology-oncology patients: Results of a French nationwide survey: D ELEBARRE ET AL. Pediatr Blood Cancer, vol.63, pp.2167-72, 2016.

N. Entz-werle, S. Suciu, J. Van-der-werff-ten-bosch, E. Vilmer, Y. Bertrand et al., Results of 58872 and 58921 trials in acute myeloblastic leukemia and relative value of chemotherapy vs allogeneic bone marrow transplantation in first complete remission: the EORTC Children Leukemia Group report, Leukemia, vol.19, issue.12, pp.2072-81, 2005.

N. Thacker, N. Pereira, S. D. Banavali, G. Narula, T. Vora et al., Epidemiology of blood stream infections in pediatric patients at a Tertiary Care Cancer Centre, Indian J Cancer, vol.51, issue.4, pp.438-479, 2014.

A. Felix, T. Leblanc, A. Petit, B. Nelkem, Y. Bertrand et al., Acute Myeloid Leukemia With Central Nervous System Involvement in Children: Experience From the French Protocol Analysis ELAM02, J Pediatr Hematol Oncol, vol.40, issue.1, pp.43-50, 2018.

A. Biondi, M. Schrappe, D. Lorenzo, P. Castor, A. Lucchini et al., Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosomepositive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study, Lancet Oncol, vol.13, issue.9, pp.936-981, 2012.

C. Domenech, M. Mercier, E. Plouvier, M. Puraveau, P. Bordigoni et al., First isolated extramedullary relapse in children with B-cell precursor acute lymphoblastic leukaemia: results of the Cooprall-97 study, Eur J Cancer Oxf Engl, vol.44, issue.16, pp.2461-2470, 1990.
URL : https://hal.archives-ouvertes.fr/hal-00485405

E. Landmann, B. Burkhardt, M. Zimmermann, U. Meyer, W. Woessmann et al., Results and conclusions of the European Intergroup EURO-LB02 trial in children and adolescents with lymphoblastic lymphoma, Haematologica, vol.102, issue.12, pp.2086-96, 2017.

M. S. Cairo, R. Sposto, M. Gerrard, A. Auperin, S. C. Goldman et al., Advanced stage, increased lactate dehydrogenase, and primary site, but not adolescent age (? 15 years), are associated with an increased risk of treatment failure in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB LMB 96 study, J Clin Oncol Off J Am Soc Clin Oncol, vol.30, issue.4, pp.387-93, 2012.

G. Wrobel, A. Mauguen, A. Rosolen, A. Reiter, D. Williams et al., Safety assessment of intensive induction therapy in childhood anaplastic large cell lymphoma: report of the ALCL99 randomised trial. Pediatr Blood Cancer, vol.56, pp.1071-1078, 2011.

J. Worch, A. Ranft, S. G. Dubois, M. Paulussen, H. Juergens et al., Age dependency of primary tumor sites and metastases in patients with Ewing sarcoma, Pediatr Blood Cancer, 2018.

J. Wilde, D. C. Aronson, B. Sznajder, H. Van-tinteren, M. Powis et al., Nephron sparing surgery (NSS) for unilateral wilms tumor (UWT): the SIOP 2001 experience. Pediatr Blood Cancer, vol.61, pp.2175-2184, 2014.

N. Gaspar, B. Occean, H. Pacquement, E. Bompas, C. Bouvier et al., Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study, Eur J Cancer Oxf Engl, vol.88, pp.57-66, 1990.
URL : https://hal.archives-ouvertes.fr/inserm-01667245

D. A. Morgenstern, U. Pötschger, L. Moreno, V. Papadakis, C. Owens et al., Risk stratification of high-risk metastatic neuroblastoma: A report from the

/. Siopen, Pediatr Blood Cancer, 2018.

C. Domenech, C. Leick-courtois, A. Bienvenu, J. Pracros, S. Picot et al., Improvement in the Outcome of Invasive Aspergillosis in a Pediatric Hematology Department: A 10-Year Review, J Pediatr Hematol Oncol, vol.37, issue.7, pp.560-565, 2015.

A. S. Brunet, C. Ploton, C. Galambrun, C. Pondarré, M. P. Pages et al., Low incidence of sepsis due to viridans streptococci in a ten-year retrospective study of pediatric acute myeloid leukemia. Pediatr Blood Cancer, vol.47, pp.765-72, 2006.

A. Magiorakos, A. Srinivasan, R. B. Carey, Y. Carmeli, M. E. Falagas et al., Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance, Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis, vol.18, issue.3, pp.268-81, 2012.

T. Mvalo, B. Eley, C. Bamford, C. Stanley, M. Chagomerana et al., Bloodstream infections in oncology patients at Red Cross War Memorial Children's Hospital, Cape Town, from 2012 to 2014, Int J Infect Dis IJID Off Publ Int Soc Infect Dis, vol.77, pp.40-47, 2018.

A. Simon, R. Furtwängler, N. Graf, H. J. Laws, S. Voigt et al., Surveillance of bloodstream infections in pediatric cancer centers -what have we learned and how do we move on?, GMS Hyg Infect Control, vol.11, p.11, 2016.

T. A. Hooven and R. A. Polin, Healthcare-associated infections in the hospitalized neonate: a review, Early Hum Dev, vol.90, pp.4-6, 2014.

T. Lehrnbecher, R. Phillips, A. S. Alvaro, F. Carlesse, F. Fisher et al., Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem-cell transplantation, J Clin Oncol Off J Am Soc Clin Oncol, vol.30, issue.35, pp.4427-4465, 2012.

D. Hoegy, S. Goutelle, N. Garnier, C. Rénard, C. Faure-conter et al., Continuous intravenous vancomycin in children with normal renal function hospitalized in hematology-oncology: prospective validation of a dosing regimen optimizing steady-state concentration, Fundam Clin Pharmacol, vol.32, issue.3, pp.323-332, 2018.

J. Whangbo, J. Ritz, and A. Bhatt, Antibiotic-mediated modification of the intestinal microbiome in allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplant, vol.52, issue.2, pp.183-90, 2017.

T. Lehrnbecher, H. Laws, A. Boehm, M. Dworzak, G. Janssen et al., Compliance with anti-infective preventive measures: A multicentre survey among paediatric oncology patients, Eur J Cancer Oxf Engl, vol.44, issue.13, pp.1861-1866, 1990.

, Mon premier souci sera, de rétablir, de préserver ou de promouvoir la santé dans tous les éléments physiques et mentaux, individuels collectifs et sociaux. Je respecterai toutes les personnes, leur autonomie et leur volonté, sans aucune discrimination selon leur

, J'interviendrai pour les protéger si elles sont affaiblies, vulnérables ou menacées dans leur intégrité ou dignité

, Même sous la contrainte, je ne ferai usage de mes connaissances contre les lois de l'humanité

, Je ne tromperai jamais leur confiance et n'exploiterai pas le pouvoir hérité des circonstances pour forcer leurs consciences

, Je donnerai mes soins à l'indigent et à quiconque me les demandera

, Je ne me laisserai influencer ni par la recherche du gain ni par la recherche de la gloire

, Reçu à l'intérieur des maisons, je respecterai les secrets des foyers. Et ma conduite ne servira pas à corrompre les moeurs

, Je n'entreprendrai rien qui ne dépasse mes compétences ; je les entretiendrai et les perfectionnerai pour assurer au mieux les services qui me seront demandés, Je ferai tout pour soulager les souffrances, sans acharnement

, J'apporterai mon aide à mes confrères ainsi qu'à leurs familles dans l'adversité

, Que les hommes et mes confrères m'accordent leur estime si je suis fidèle à mes promesses, Que je sois déshonoré et méprisé si j'y manque