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, For Marseille : Plasma ACTH and cortisol, and UFC were measured by commercial radioimmunoassay kits

, The intra-and inter-assay coefficients of variation were 6, ACTH concentrations were determined by radioimmunoassay assay, p.9

, 1%, and 6.2-9.6% respectively. The detection limit was 1,2 pg/mL

, The intra-and inter-assay coefficients of variation were 2, Cortisol concentrations were determined by radioimmunoassay assay

, 1% and 5.3-9.2% respectively. The detection limit was 10 nmol/L. UFC concentrations were determined by radioimmunoassay

F. Marseille,

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R. En and . Objectif, Nous avons évalué, à l'aide de critères standardisés, si une réponse hormonale persistante au DT prédisait une récidive chez les patients présentant une IC postopératoire. Design: Étude rétrospective multicentrique Méthodes: Le DT était réalisé pour 95 MC (femmes: 82%, âgés de 41±14 ans), répondant à la desmopressine en préopératoire, présentant une IC postopératoire dans les 3 mois après la chirurgie. L'association entre les paramètres du DT et la récidive était testée à l'aide d'analyses de régression linéaire et logistique. Sa prévision était évaluée à l'aide d'analyses ROC. Résultats: Une récidive survenait chez 17/95 patients suivis 61 (29, 91) mois, La maladie de Cushing (MC) peut récidiver malgré l'obtention d'une insuffisance corticotrope (IC) après chirurgie hypophysaire. Dans ce contexte, la valeur prédictive du test à la desmopressine (DT) reste controversée, pp.63-102

, Cette association persistait après différents ajustements, sans interaction avec le cortisol postopératoire. Le pic de cortisol lors du DT, nmol/L, p=0,03. Le pic de cortisol lors du DT était plus élevé dans le groupe récidive versus le groupe en rémission, vol.327

, Conclusion: Le pic de cortisol au cours du DT est associé indépendamment à la récidive de la MC et offre une valeur pronostique incrémentielle, permettant une stratification des patients en IC pour affiner leur suivi en fonction du risque de récidive

, Au moment d'être admise à exercer la médecine, je promets et je jure d'être fidèle aux lois de l'honneur et de la probité

, Mon premier souci sera de rétablir, de préserver ou de promouvoir la santé dans tous ses éléments, physiques et mentaux, individuels et sociaux

, Je respecterai toutes les personnes, leur autonomie et leur volonté, sans aucune discrimination selon leur état ou leurs convictions. J'interviendrai pour les protéger si elles sont affaiblies, vulnérables ou menacées dans leur intégrité ou leur dignité. Même sous la contrainte

, Je ne tromperai jamais leur confiance et n'exploiterai pas le pouvoir hérité des circonstances

, Admise dans l'intimité des personnes, je tairai les secrets qui me seront confiés. Reçue à l'intérieur des maisons, je respecterai les secrets des foyers et ma conduite ne servira pas à

, J'apporterai mon aide à mes confrères ainsi qu'à leurs familles dans l'adversité

, Que les Hommes et mes confrères m'accordent leur estime si je suis fidèle à mes promesses