, Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies, Lancet HIV, vol.4, issue.8, pp.349-56, 2017.
, Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies, Lancet Lond Engl, vol.372, issue.9635, pp.293-302, 2008.
Premature age-related comorbidities among HIV-infected persons compared with the general population, Clin Infect Dis Off Publ Infect Dis Soc Am, 2011. ,
Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.59, issue.12, pp.1787-97, 2014. ,
Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence, Aging Dis, vol.2, issue.5, pp.382-97, 2011. ,
HIV-associated cellular senescence: A contributor to accelerated aging, Ageing Res Rev, vol.36, pp.117-141, 2017. ,
Frailty and Circulating Markers of Inflammation in HIV+ and HIV? Men in the Multicenter AIDS Cohort Study, JAIDS J Acquir Immune Defic Syndr, vol.74, issue.4, pp.407-424, 2017. ,
The End of AIDS: HIV Infection as a Chronic Disease, Lancet, vol.382, issue.9903, pp.1525-1558, 2013. ,
Noncommunicable diseases among HIV-infected persons in low-income and middle-income countries: a systematic review and meta-analysis, AIDS Lond Engl, vol.32, issue.1, pp.5-20, 2018. ,
Approaches to Improve the Surveillance, Monitoring, and Management of Noncommunicable Diseases in HIV-Infected Persons: Viewpoint. JMIR Public Health Surveill, vol.4, p.10989, 2018. ,
HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty, J Gerontol A Biol Sci Med Sci, vol.62, issue.11, pp.1279-86, 2007. ,
Frailty in older adults: evidence for a phenotype, J Gerontol A Biol Sci Med Sci, vol.56, issue.3, pp.146-156, 2001. ,
Reduced bone mineral density in HIV-infected patients: prevalence and associated factors, AIDS Lond Engl, vol.22, issue.3, pp.395-402, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00186715
High frequency of poor locomotor performance in HIV-infected patients, AIDS Lond Engl, vol.25, issue.6, pp.797-805, 2011. ,
Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort, Alzheimers Res Ther, vol.9, issue.1, p.67, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01981009
Cognitive disorders in HIV-infected patients: are they HIV-related?, AIDS Lond Engl, vol.27, issue.3, pp.391-400, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01101101
Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score. Public Health Nutr, vol.17, pp.2769-82, 2014. ,
, Int J Infect Dis IJID Off Publ Int Soc Infect Dis, vol.53, pp.61-69, 2016.
Ageing with HIV. Healthc Basel Switz, vol.6, 2018. ,
Faces of Frailty in Aging with HIV Infection, Curr HIV/AIDS Rep, vol.14, issue.1, pp.31-38, 2017. ,
Functional impairment is associated with low bone and muscle mass among persons aging with HIV infection, J Acquir Immune Defic Syndr, vol.63, issue.2, pp.209-224, 1999. ,
Comparison of functional status instruments in HIV-infected adults on effective antiretroviral therapy, HIV Clin Trials, vol.13, issue.6, pp.324-358, 2012. ,
Geriatric Syndromes in Older HIV-Infected Adults, J Acquir Immune Defic Syndr, vol.69, issue.2, pp.161-168, 1999. ,
The relationship of physical performance with HIV disease and mortality, AIDS Lond Engl, vol.28, issue.18, pp.2711-2720, 2014. ,
Epidemiology of ageing with HIV: what can we learn from cohorts? AIDS Lond Engl, vol.31, pp.121-129, 201701. ,
HIV and Aging -Perhaps Not as Dramatic as We Feared?, Gerontology, vol.64, issue.5, pp.446-56, 2018. ,
Stable bone density in HAART-treated individuals with HIV: a meta-analysis, J Clin Endocrinol Metab, vol.96, issue.9, pp.2721-2752, 2011. ,
Stable bone mineral density over 6 years in HIV-infected men treated with highly active antiretroviral therapy (HAART), Clin Endocrinol, p.2012 ,
Lean mass index: a better predictor of mortality than body mass index in elderly Asians, J Am Geriatr Soc, vol.58, issue.2, pp.312-319, 2010. ,
Fat distribution and metabolic changes in patients with HIV infection, AIDS Lond Engl, 1999. ,
Antiretrovirals, Fractures, and Osteonecrosis in a Large International HIV Cohort, vol.64, pp.1413-1434, 2017. ,
Bone Mineral Density Declines Twice as Quickly Among HIV-Infected Women Compared With Men, J Acquir Immune Defic Syndr, vol.77, issue.3, pp.288-94, 1999. ,
Decline in locomotor functions over time in HIV-infected patients, AIDS Lond Engl, vol.28, issue.10, pp.1441-1450, 2014. ,
Assessment and Management of HIV-Associated Cognitive Impairment: Experience from a Multidisciplinary Memory Service for People Living with HIV, Brain Sci, vol.9, issue.2, 2019. ,
Antiretroviral therapy protects against frailty in HIV-1 infection ,
, J Int Assoc Provid AIDS Care, vol.12, issue.1, pp.62-68, 2013.
Mediterranean diet and cardiovascular disease: historical perspective and latest evidence, Curr Atheroscler Rep, vol.15, issue.12, p.370, 2013. ,
Changes in total body bone mineral density following a common bone health plan with two versions of a unique bone health supplement: a comparative effectiveness research study, Nutr J, vol.10, p.32, 2011. ,
Prospective study of Dietary Approaches to Stop Hypertension-and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging, Am J Clin Nutr, vol.98, issue.5, pp.1263-71, 2013. ,
Evaluation of high-protein supplementation in weight-stable HIV-positive subjects with a history of weight loss: a randomized, double-blind, multicenter trial, Am J Clin Nutr, vol.88, issue.5, pp.1313-1334, 2008. ,
A natural product telomerase activator as part of a health maintenance program, Rejuvenation Res, vol.14, issue.1, pp.45-56, 2011. ,
Nutrition assessment, counseling, and support interventions to improve health-related outcomes in people living with HIV/AIDS: a systematic review of the literature, J Acquir Immune Defic Syndr, vol.68, issue.3, pp.340-349, 1999. ,
, Recommended Treatment Strategies for Clinicians Managing Older Patients with HIV
, Bibliographie de l'introduction 1. Diagnoses of HIV infection among adults aged 50 years and older in the United States and dependent areas, p.118, 2011.
, HIV Among People Aged 50 and Over | Age | HIV by Group | HIV/AIDS | CDC, HIV/AIDS surveillance in Europe -WHO 2017, 2018.
, HIV/AIDS (UNAIDS) UNP on. HIV and Aging: A special supplement to the UNAIDS report on the global AIDS epidemic, 2013.
VIH/sida -Données épidémiologique, 2018. ,
, , 2018.
Future challenges for clinical care of an ageing population infected with HIV: a modelling study, Lancet Infect Dis, vol.15, issue.7, pp.810-818, 2015. ,
Life expectancy in HIV-positive persons in Switzerland: matched comparison with general population, AIDS Lond Engl, vol.31, issue.3, pp.427-463, 2017. ,
, Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies, Lancet HIV, vol.4, issue.8, pp.349-56, 2017.
Changes in the cause of death among HIV positive subjects across Europe: results from the EuroSIDA study, AIDS Lond Engl, vol.16, issue.12, pp.1663-71, 2002. ,
Trends in underlying causes of death in people with HIV from, vol.384, pp.241-249, 1999. ,
Causes of death among HIV-infected patients in France in 2010 (national survey): trends since, AIDS Lond Engl, vol.28, issue.8, pp.1181-91, 2000. ,
Impact of Non-HIV and HIV Risk Factors on Survival in HIV-Infected Patients on HAART: A Population-Based Nationwide Cohort Study, PLoS ONE, vol.6, issue.7, 2011. ,
Risk of Cardiovascular Disease in an Aging HIV Population: Where Are We Now? Curr HIV/AIDS Rep, vol.12, pp.375-87, 2015. ,
Patterns of Cardiovascular Mortality for HIV-Infected Adults in the United States: 1999 to 2013, Am J Cardiol, vol.117, issue.2, pp.214-234, 2016. ,
Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study, J Acquir Immune Defic Syndr, vol.43, issue.1, pp.27-34, 1999. ,
Trends and determinants of severe morbidity in HIV-infected patients: the ANRS CO3 Aquitaine Cohort, HIV Med, vol.8, issue.8, pp.547-54, 2000. ,
Premature age-related comorbidities among HIV-infected persons compared with the general population, Clin Infect Dis Off Publ Infect Dis Soc Am, 2011. ,
HIV infection, inflammation, immunosenescence, and aging, Annu Rev Med, vol.62, pp.141-55, 2011. ,
Frailty in older adults: evidence for a phenotype, J Gerontol A Biol Sci Med Sci, vol.56, issue.3, pp.146-156, 2001. ,
Frailty in elderly people, Lancet Lond Engl, vol.381, issue.9868, pp.752-62, 2013. ,
HIV infection is independently associated with frailty in middle-aged HIV type 1-infected individuals compared with similar but uninfected controls, AIDS Lond Engl, vol.30, issue.2, pp.241-50, 2016. ,
Geriatric Syndromes in Older HIV-Infected Adults, J Acquir Immune Defic Syndr, vol.69, issue.2, pp.161-168, 1999. ,
A review of premature frailty in HIV-infected persons; another manifestation of HIV-related accelerated aging, Curr Aging Sci, vol.4, issue.1, pp.33-41, 2011. ,
Geriatric Assessments and Association With VACS Index Among HIV-Infected Older Adults in San Francisco, J Acquir Immune Defic Syndr, vol.72, issue.5, pp.534-575, 1999. ,
Correlates of Prevalent Disability Among HIV-Infected Elderly Patients, AIDS Res Hum Retroviruses, vol.32, issue.2, pp.155-62, 2016. ,
Relationship between a frailtyrelated phenotype and progressive deterioration of the immune system in HIV-infected men, J Acquir Immune Defic Syndr, vol.50, issue.3, pp.299-306, 1999. ,
The Silent Epidemic -Frailty and Aging with HIV. Total Patient Care HIV HCV, vol.1, pp.6-17, 2016. ,
An internationally generalizable risk index for mortality after one year of antiretroviral therapy, AIDS Lond Engl, vol.27, issue.4, pp.563-72, 2013. ,
Short communication: The Veterans Aging Cohort Study Index is an effective tool to assess baseline frailty status in a contemporary cohort of HIV-infected persons, AIDS Res Hum Retroviruses, vol.31, issue.3, pp.313-320, 2015. ,
Physiologic frailty and fragility fracture in HIV-infected male veterans, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.56, issue.10, pp.1498-504, 2013. ,
Frailty in people aging with human immunodeficiency virus (HIV) infection, J Infect Dis, vol.210, issue.8, pp.1170-1179, 2014. ,
Frailty is an independent risk factor for mortality, cardiovascular disease, bone disease and diabetes among aging adults with HIV, Clin Infect Dis Off Publ Infect Dis Soc Am, 2018. ,
, , p.4
, T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy, J Infect Dis, vol.187, issue.10, pp.1534-1577, 2003.
Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection, J Infect Dis, vol.201, issue.12, pp.1788-95, 2010. ,
Inflammatory and coagulation biomarkers and mortality in patients with HIV infection, PLoS Med, vol.5, issue.10, p.203, 2008. ,
Plasma levels of soluble CD14 independently predict mortality in HIV infection, J Infect Dis, vol.203, issue.6, pp.780-90, 2011. ,
Soluble CD163, a novel marker of activated macrophages, is elevated and associated with noncalcified coronary plaque in HIV-infected patients, J Infect Dis, vol.204, issue.8, pp.1227-1263, 2011. ,
Evidence for innate immune system activation in HIV type 1-infected elite controllers, J Infect Dis, vol.209, issue.6, pp.931-940, 2014. ,
Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy, AIDS Lond Engl, vol.25, issue.17, pp.2123-2154, 2011. ,
age-related comorbidities and mortality: association of activation, senescence and inflammation markers in HIV adults, AIDS, 2018. ,
Association of immune-activation and senescence markers with non-AIDS-defining comorbidities in HIV-suppressed patients, AIDS Lond Engl, vol.29, issue.16, pp.2099-108, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01288887
Microbial translocation is a cause of systemic immune activation in chronic HIV infection, Nat Med, vol.12, issue.12, pp.1365-71, 2006. ,
Effect of cytomegalovirus-induced immune response, self antigen-induced immune response, and microbial translocation on chronic immune activation in successfully treated HIV type 1-infected patients: the ANRS CO3 Aquitaine Cohort, J Infect Dis, vol.207, issue.4, pp.622-629, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01101196
Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy, PloS One, vol.11, issue.5, p.155100, 2016. ,
Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation, Blood, vol.115, issue.2, pp.161-168, 2010. ,
Severity of cardiovascular disease outcomes among patients with HIV is related to markers of inflammation and coagulation, J Am Heart Assoc, vol.3, issue.3, p.844, 2014. ,
Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence, Aging Dis, vol.2, issue.5, pp.382-97, 2011. ,
Immunosenescence and immunogenetics of human longevity, Neuroimmunomodulation, vol.15, pp.224-264, 2008. ,
Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.48, issue.3, pp.350-61, 2009. ,
CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study, Lancet HIV, vol.2, issue.3, pp.98-106, 2015. ,
The role of HIV in serious diseases other than AIDS, AIDS Lond Engl, vol.22, issue.18, pp.2409-2427, 2008. ,
CD4+ count-guided interruption of antiretroviral treatment, N Engl J Med, vol.355, issue.22, pp.2283-96, 2006. ,
STOPP/START criteria for potentially inappropriate prescribing in older people: version 2, Age Ageing, vol.44, issue.2, pp.213-221, 2015. ,
Acute coronary syndromes in patients with HIV. Coron Artery Dis, vol.28, pp.166-72, 2017. ,
Association between HIV infection, antiretroviral therapy, and risk of acute myocardial infarction: a cohort and nested case-control study using Québec's public health insurance database, J Acquir Immune Defic Syndr, vol.57, issue.3, pp.245-53, 1999. ,
Cardiovascular disease and use of contemporary protease inhibitors: the D:A:D international prospective multicohort study, Lancet HIV, vol.5, issue.6, pp.291-300, 2018. ,
Relative risk of cardiovascular disease among people living with HIV: a systematic review and meta-analysis, HIV Med, vol.13, issue.8, pp.453-68, 2012. ,
Increased Risk of Myocardial Infarction in HIV-Infected Individuals in North America Compared With the General Population, J Acquir Immune Defic Syndr, vol.75, issue.5, pp.568-76, 1999. ,
, Cardiovascular Disease Mortality Among Persons With HIV in, vol.63, pp.1122-1131, 2001.
Projecting 10-year, 20-year, and Lifetime Risks of Cardiovascular Disease in Persons Living With Human Immunodeficiency Virus in the United States, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.65, issue.8, pp.1266-71, 201715. ,
Factor analysis of the metabolic syndrome: obesity vs insulin resistance as the central abnormality, Int J Obes, vol.25, issue.12, pp.1782-1790, 2001. ,
Metabolic syndrome in HIV-infected individuals: underlying mechanisms and epidemiological aspects, AIDS Res Ther, vol.10, issue.1, p.32, 2013. ,
Impact of HIV infection and HAART on serum lipids in men, JAMA, vol.289, issue.22, pp.2978-82, 2003. ,
Altered relationship of plasma triglycerides to HDL cholesterol in patients with HIV/HAART-associated dyslipidemia: further evidence for a unique form of metabolic syndrome in HIV patients, Metabolism, vol.62, issue.7, pp.1014-1034, 2013. ,
A randomized cross-over study to compare raltegravir and efavirenz (SWITCH-ER study), AIDS Lond Engl, vol.25, issue.12, pp.1481-1488, 2011. ,
Fat distribution and metabolic changes in patients with HIV infection, AIDS Lond Engl, 1999. ,
Long-term body fat outcomes in antiretroviral-naive participants randomized to nelfinavir or efavirenz or both plus dual nucleosides. Dual X-ray absorptiometry results from A5005s, a substudy of Adult Clinical Trials Group 384, J Acquir Immune Defic Syndr, vol.45, issue.5, pp.508-522, 1999. ,
A tale of 2 epidemics: the intersection between obesity and HIV infection in Philadelphia, J Acquir Immune Defic Syndr, vol.39, issue.5, pp.557-61, 1999. ,
Minireview: adiposity, inflammation, and atherogenesis, Endocrinology, 2003. ,
Association of Upper Trunk and Visceral Adipose Tissue Volume With Insulin Resistance in Control and HIV-Infected Subjects in the FRAM Study ,
, J Acquir Immune Defic Syndr, vol.46, issue.3, pp.283-90, 1999.
Body mass index, immune status, and virological control in HIV-infected men who have sex with men, J Int Assoc Provid AIDS Care, vol.12, issue.5, pp.319-343, 2013. ,
An optimal body mass index range associated with improved immune reconstitution among HIV-infected adults initiating antiretroviral therapy, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.53, issue.9, pp.952-60, 2011. ,
Weight change after antiretroviral therapy and mortality, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.60, issue.12, pp.1852-1861, 2015. ,
A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus, J Am Geriatr Soc, vol.60, issue.3, pp.545-554, 2012. ,
Prevalence of metabolic syndrome in HIV-infected patients receiving highly active antiretroviral therapy using International Diabetes Foundation and Adult Treatment Panel III criteria: associations with insulin resistance, disturbed body fat compartmentalization, elevated C-reactive protein, and [corrected] hypoadiponectinemia. Diabetes Care, vol.30, pp.113-122, 2007. ,
Is there sufficient evidence for a causal association between antiretroviral therapy and diabetes in HIV-infected patients? A meta-analysis, Diabetes Metab Res Rev, issue.6, p.33, 2017. ,
HIV therapy and diabetes risk. Diabetes Care, vol.31, pp.1267-1275, 2008. ,
Effects of GH replacement on endothelial function and large-artery stiffness in GH-deficient adults: a randomized, double-blind, placebocontrolled study, Clin Endocrinol (Oxf), vol.56, issue.4, pp.493-501, 2002. ,
HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation, BMC Infect Dis, 2017. ,
Reduced bone mineral density in HIV-infected patients: prevalence and associated factors, AIDS Lond Engl, vol.22, issue.3, pp.395-402, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00186715
Potential predictive factors of osteoporosis in HIV-positive subjects, Bone, vol.38, issue.6, pp.893-900, 2006. ,
The Hidden Burden of Fractures in People Living With HIV, JBMR Plus, 2018. ,
Low bone mineral density and risk of incident fracture in HIV-infected adults, Antivir Ther, vol.21, issue.1, pp.45-54, 2016. ,
Antiretrovirals, Fractures, and Osteonecrosis in a Large International HIV Cohort, vol.64, pp.1413-1434, 2017. ,
Changes in Bone Mineral Density After Initiation of Antiretroviral Treatment With Tenofovir Disoproxil Fumarate/Emtricitabine Plus Atazanavir/Ritonavir, Darunavir/Ritonavir, or Raltegravir, J Infect Dis, vol.212, issue.8, pp.1241-1250, 2015. ,
Changes in bone mineral density over a 2-year period in HIV-1-infected men under combined antiretroviral therapy with osteopenia, AIDS Lond Engl, 2013. ,
Cancer-Related Causes of Death among HIV-Infected Patients in France in 2010: Evolution since, PloS One, vol.10, issue.6, p.129550, 2000. ,
URL : https://hal.archives-ouvertes.fr/hal-01289134
HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies, AIDS Lond Engl, vol.22, issue.16, pp.2143-53, 2008. ,
Cancer-Attributable Mortality Among People With Treated Human Immunodeficiency Virus Infection in North America, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.65, issue.4, pp.636-679, 2017. ,
Incidence and risk factors for the occurrence of non-AIDS-defining cancers among human immunodeficiency virus-infected individuals, Cancer, vol.104, issue.7, pp.1505-1516, 2005. ,
Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis, Lancet Lond Engl, vol.370, issue.9581, pp.59-67, 2007. ,
HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors, J Neurovirol, vol.17, issue.1, pp.3-16, 2011. ,
Effects of comorbidity burden and age on brain integrity in HIV, AIDS Lond Engl, vol.33, issue.7, pp.1175-85, 2019. ,
Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.60, issue.3, pp.473-80, 2015. ,
Cognitive disorders in HIV-infected patients: are they HIV-related?, AIDS Lond Engl, vol.27, issue.3, pp.391-400, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01101101
Does antiretroviral therapy improve HIV-associated cognitive impairment? A quantitative review of the literature, J Int Neuropsychol Soc JINS, vol.17, issue.6, pp.956-69, 2011. ,
Neurocognitive functioning predicts frailty index in HIV, Neurology, vol.91, issue.2, pp.162-70, 2018. ,
The changing epidemiology of HIV-related chronic kidney disease in the era of antiretroviral therapy, Kidney Int, vol.86, issue.2, pp.259-65, 2014. ,
How to manage HIV-infected patients with chronic kidney disease in the HAART era, Clin Exp Nephrol, vol.16, issue.3, pp.363-72, 2012. ,
Role of traditional risk factors and antiretroviral drugs in the incidence of chronic kidney disease, ANRS CO3 Aquitaine cohort, vol.8, issue.6, p.66223, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-01101114
Activation, senescence and inflammation markers in HIV patients: association with renal function, AIDS Lond Engl, vol.31, issue.8, pp.1119-1147, 201715. ,
The End of AIDS: HIV Infection as a Chronic Disease, Lancet, vol.382, issue.9903, pp.1525-1558, 2013. ,