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Master Thesis

Dilatation ventriculaire gauche au cours de la drépanocytose homozygote : évaluation de l’impact pronostic

Abstract : Backgrounds: sickle cell disease is the most frequent haemoglobinopathy in the world. Cardiac complications are associated with high mortality. Left ventricle (LV) dilatation is common in homozygous patients (ie, sickle cell anemia) but its prognosis impact is unclear. Methods: a monocenter observational retrospective study during ten years period was conducted. We included homozygous SS or Sb0 patients who underwent a comprehensive echocardiography during routine follow-up. Main outcome was death or an episode of congestive heart failure. LV dilatation was assessed using LV end diastolic volume index (LVEDVi). Results: between March 2007 and December 2017, 413 patients were included. An LV dilation was observed in 85% of the patients. During a median follow-up of 71 months, a major event was observed in 33 patients. The LVEDVi was similar (p=0.93) in patients who encountered the primary end-point as compared to the rest of the cohort. Additional analyses using Kaplan-Meier curves and a Cox regression model did not identify any impact of LVEDVi on the prognosis. Conclusion: the LV dilatation observed in sickle cell anemia patients is not linked with mid-term prognosis.
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Master Thesis
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Submitted on : Friday, February 5, 2021 - 2:46:25 PM
Last modification on : Wednesday, February 10, 2021 - 3:20:55 AM
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  • HAL Id : dumas-02505879, version 1


Gary Dieusait. Dilatation ventriculaire gauche au cours de la drépanocytose homozygote : évaluation de l’impact pronostic. Médecine humaine et pathologie. 2019. ⟨dumas-02505879⟩



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