Neuropsychiatric outcomes of stroke, Lancet Neurol. mai, vol.13, issue.5, pp.525-559, 2014. ,
Inflammation and Depression: Why Poststroke Depression may be the Norm and Not the Exception, International Journal of Stroke. avr, vol.6, issue.2, pp.128-163, 2011. ,
The association of late-life depression and anxiety with physical disability: a review of the literature and prospectus for future research, Am J Geriatr Psychiatry, vol.9, issue.2, pp.113-148, 2001. ,
Association between depression and mortality in older adults: the Cardiovascular Health Study, Arch Intern Med. 26 juin, vol.160, issue.12, pp.1761-1769, 2000. ,
Anxiety and depressive symptoms after stroke in 9 rehabilitation centers, J Med Assoc Thai, vol.91, issue.10, pp.1595-602, 2008. ,
Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association, Stroke. févr, vol.48, issue.2, pp.30-43, 2017. ,
Predictors of depression and anxiety in community dwelling stroke survivors: a cohort study, Disabil Rehabil, vol.36, issue.23, pp.1975-82, 2014. ,
Gender and stress in predicting depressive symptoms following stroke, Cerebrovasc Dis, vol.38, issue.4, pp.240-246, 2014. ,
Post stroke depression: The sequelae of cerebral stroke, Neuroscience & Biobehavioral Reviews. juill, vol.90, pp.104-118, 2018. ,
Part II: predictors of depression after stroke and impact of depression on stroke outcome: an updated systematic review of observational studies, Int J Stroke. déc, vol.9, issue.8, pp.1026-1062, 2014. ,
Post stroke depression: epidemiology, pathophysiology, and biological treatment, Biological Psychiatry. août, vol.52, issue.3, pp.253-64, 2002. ,
Microstructural abnormality in white matter, regulatory T lymphocytes, and depressive symptoms after stroke: Regulatory T cells in stroke patients, Psychogeriatrics. déc, vol.14, issue.4, pp.213-234, 2014. ,
The Neurobiology of Depression: an Integrated Overview from Biological Theories to Clinical Evidence, Molecular Neurobiology. sept, vol.54, issue.7, pp.4847-65, 2017. ,
Post-stroke depression: Mechanisms and pharmacological treatment, Pharmacology & Therapeutics. avr, vol.184, pp.131-175, 2018. ,
Mood disorder as a specific complication of stroke, J Neurol Neurosurg Psychiatry, vol.40, issue.10, pp.1018-1038, 1977. ,
The role of neuroinflammation and neurovascular dysfunction in major depressive disorder, Journal of Inflammation Research. mai, vol.11, pp.179-92, 2018. ,
Systematic hypothesis for post-stroke depression caused inflammation and neurotransmission and resultant on possible treatments, vol.6, 2014. ,
Cytokines and psychopathology: lessons from interferon-alpha, Biol Psychiatry. 1 déc, vol.56, issue.11, pp.819-843, 2004. ,
Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action, Physiol Rev. janv, vol.79, issue.1, pp.1-71, 1999. ,
Lymphocytic infiltration and expression of intercellular adhesion molecule-1 in photochemically induced ischemia of the rat cortex, J Cereb Blood Flow Metab. janv, vol.15, issue.1, pp.42-51, 1995. ,
Coagulation and sepsis, Thromb Res. janv, vol.149, pp.38-44, 2017. ,
The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression, Neuro Endocrinol Lett. juin, vol.29, issue.3, pp.287-91, 2008. ,
Increase in interleukin-1beta in late-life depression, Am J Psychiatry. janv, vol.162, issue.1, pp.175-182, 2005. ,
Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder, Psychopharmacology (Berl). déc, vol.170, issue.4, pp.429-462, 2003. ,
Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications, J Clin Endocrinol Metab. mai, vol.90, issue.5, pp.2522-2552, 2005. ,
Body Image & Quality of Life: Changes With Gastric Bypass and Body Contouring, Annals of Plastic Surgery. mai, vol.76, pp.216-237, 2016. ,
The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice, Psychoneuroendocrinology, vol.25, issue.8, pp.785-97, 2000. ,
Depression and vascular disease: what is the relationship?, J Affect Disord. avr, vol.79, issue.1-3, pp.81-95, 2004. ,
Enhanced adrenal sensitivity to adrenocorticotrophic hormone (ACTH) is evidence of HPA axis hyperactivity in Alzheimer's disease, Psychol Med. janv, vol.26, issue.1, pp.7-14, 1996. ,
Major depression and stages of smoking. A longitudinal investigation, Arch Gen Psychiatry. févr, vol.55, issue.2, pp.161-167, 1998. ,
Assessment of depression in patients with brain pathology: the case of stroke, Psychol Bull. sept, vol.122, issue.2, pp.132-52, 1997. ,
Poststroke Depression Biomarkers: A Narrative Review, Front Neurol, vol.9, p.577, 2018. ,
What's CRP got to do with it? Tackling the complexities of the relationship between CRP and depression, Brain, Behavior, and Immunity. oct, vol.73, pp.163-167, 2018. ,
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis, Psychosom Med. févr, vol.71, issue.2, pp.171-86, 2009. ,
CRP, IL-6 and depression: A systematic review and metaanalysis of longitudinal studies, Journal of Affective Disorders. sept, vol.150, issue.3, pp.736-780, 2013. ,
Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression, Brain, Behavior, and Immunity. mai, vol.62, pp.344-50, 2017. ,
hs-CRP Predicts Improvement in Depression in Patients With Type 1 Diabetes and Major Depression Undergoing Depression Treatment: Results From the Diabetes and Depression (DAD) Study. Diabetes Care, vol.39, pp.171-174, 2016. ,
Chronic low-grade peripheral inflammation is associated with ultra resistant schizophrenia. Results from the FACE-SZ cohort, Eur Arch Psychiatry Clin Neurosci. 28 mai, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02473643
Serum Levels of High-sensitivity C-Reactive Protein at Admission Are More Strongly Associated with Poststroke Depression in Acute Ischemic Stroke than Homocysteine Levels, Molecular Neurobiology. mai, vol.53, issue.4, pp.2152-60, 2016. ,
Correlations of Post-stroke Depression with Inflammatory Response Factors, Iran J Public Health, vol.47, p.6, 2018. ,
Neutrophil-to-lymphocyte ratio predicts early worsening in stroke due to large vessel disease, PLoS ONE, vol.14, issue.8, p.221597, 2019. ,
Prognostic role of neutrophil-lymphocyte ratio in patients with acute ischemic stroke: Medicine, vol.96, p.8624, 2017. ,
Early increased neutrophil-to-lymphocyte ratio is associated with poor 3-month outcomes in spontaneous intracerebral hemorrhage, PLoS ONE, vol.14, issue.2, p.211833, 2019. ,
Neutrophil-to-Lymphocyte Ratio in Acute Cerebral Hemorrhage: a System Review, Transl Stroke Res. avr, vol.10, issue.2, pp.137-182, 2019. ,
The association between neutrophil-tolymphocyte ratio and post-stroke depression, Clinica Chimica Acta. nov, vol.486, pp.298-302, 2018. ,
Protein (CRP) Is Not a Mere Marker, but an Active Pathogenic Substance, Circ J, vol.75, issue.7, pp.1579-80, 2011. ,
Low-Dose Methotrexate for the Prevention of Atherosclerotic Events, N Engl J Med, vol.21, issue.8, pp.752-62, 2019. ,
Interventions for treating depression after stroke. Cochrane Database Syst Rev, p.3437, 2008. ,
, Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial, Lancet, vol.19, pp.265-74, 2019.
Efficacy of early administration of escitalopram on depressive and emotional symptoms and neurological dysfunction after stroke: a multicentre, double-blind, randomised, placebo-controlled study, Lancet Psychiatry. janv, vol.4, issue.1, pp.33-41, 2017. ,
A Meta-analysis of Randomized Control Trials: the Impact of Vitamin C Supplementation on Serum CRP and serum hs-CRP Concentrations, Curr Pharm Des, 2018. ,
Vitamin C treatment reduces elevated C-reactive protein, Free Radical Biology and Medicine. 1 janv, vol.46, issue.1, pp.70-77, 2009. ,
Efficacy of vitamin C in preventing complex regional pain syndrome after wrist fracture: A systematic review and meta-analysis, Orthop Traumatol Surg Res, vol.103, issue.3, pp.465-70, 2017. ,
Reduction of C-reactive protein levels through use of a multivitamin, The American Journal of Medicine. déc, vol.115, issue.9, pp.702-709, 2003. ,
A Self-Report Depression Scale for Research in the General Population, Applied Psychological Measurement. 1 juin, vol.1, issue.3, pp.385-401, 1977. ,
The Role of Inflammation in Depression and Fatigue, Front Immunol. 19 juill, vol.10, p.1696, 2019. ,
Combination of High-Sensitivity C-Reactive Protein and Homocysteine Predicts the Post-Stroke Depression in Patients with Ischemic Stroke, Molecular Neurobiology. avr, vol.55, issue.4, pp.2952-2960, 2018. ,
High sensitivity C reactive protein, fibrinogen levels and the onset of major depressive disorder in post-acute coronary syndrome, BMC Cardiovasc Disord. déc, vol.15, issue.1, p.23, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-02469676
Predictors of depression after stroke: a systematic review of observational studies. Stroke, vol.36, pp.2296-301, 2005. ,
The natural history of depression up to 15 years after stroke: the South London Stroke Register, Stroke. avr, vol.44, issue.4, pp.1105-1115, 2013. ,
Depression in later life: A closer look at the gender gap, Soc Sci Res, vol.68, pp.163-75, 2017. ,
Sex differences in the prevalence of post-stroke depression: a systematic review, Psychosomatics. déc, vol.50, issue.6, pp.563-572, 2009. ,
Depression, stroke and gender: evidence of a stronger association in men, J Neurol Neurosurg Psychiatry. mars, vol.86, issue.3, pp.319-342, 2015. ,
Gender differences in post-stroke depression: A longitudinal analysis of prevalence, persistence and predictive value of known risk factors, Neuropsychol Rehabil. 5 août, pp.1-17, 2019. ,
Risk factors for post-stroke depression, Int J Geriatr Psychiatry. févr, vol.12, issue.2, pp.219-245, 1997. ,
Management of depression in elderly stroke patients, Neuropsychiatr Dis Treat. 7 sept, vol.6, pp.539-588, 2010. ,
Vitamin C Inhibits NF-?B Activation by TNF Via the Activation of p38 Mitogen-Activated Protein Kinase, J Immunol. 15 déc, vol.165, issue.12, pp.7180-7188, 2000. ,
Influence of vitamin C on markers of oxidative stress in the earliest period of ischemic stroke, Pharmacological Reports. juill, vol.62, issue.4, pp.751-757, 2010. ,
Long-Term Combined Supplementations with ?-Tocopherol and Vitamin C Have No Detectable Anti-Inflammatory Effects in Healthy Men, p.4 ,
Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes, Cytokine. sept, vol.27, issue.4-5, pp.101-107, 2004. ,
Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis, J Intern Med. nov, vol.248, issue.5, pp.377-86, 2000. ,
Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress, Am J Psychiatry. sept, vol.163, issue.9, pp.1630-1633, 2006. ,
Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebocontrolled, double-blind phase 2 trial, Lancet Neurol. mars, vol.16, issue.3, pp.217-243, 2017. ,
SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A Randomized Controlled Phase 2, Trial. Stroke, vol.49, issue.5, pp.1210-1216, 2018. ,
Post-stroke inflammation-target or tool for therapy?, Acta Neuropathol. mai, vol.137, issue.5, pp.693-714, 2019. ,
Au moment d'être admis à exercer la médecine, je promets et je jure d'être fidèle aux lois de l'honneur et de la probité ,
, Mon premier souci sera de rétablir, de préserver ou de promouvoir la santé dans tous ses éléments, physiques et mentaux, individuels et sociaux
, Je respecterai toutes les personnes, leur autonomie et leur volonté, sans aucune discrimination selon leur état ou leurs convictions. J'interviendrai pour les protéger si elles sont affaiblies, vulnérables ou menacées dans leur intégrité ou leur dignité. Même sous la contrainte
, Je ne tromperai jamais leur confiance et n'exploiterai pas le pouvoir hérité des circonstances pour forcer les consciences
, Reçu à l'intérieur des maisons, je respecterai les secrets des foyers et ma conduite ne servira pas à corrompre les moeurs
, Je ne prolongerai pas abusivement les agonies. Je ne provoquerai jamais la mort délibérément
, Je n'entreprendrai rien qui dépasse mes compétences. Je les entretiendrai et les perfectionnerai pour assurer au mieux les services qui me seront demandés
, J'apporterai mon aide à mes confrères ainsi qu'à leurs familles dans l'adversité
, Que les hommes et mes confrères m'accordent leur estime si je suis fidèle à mes promesses ; que je sois déshonoré et méprisé si j'y manque