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Master Thesis

Description clinique, biologique et expérimentale des hypersensibilités immédiates à la mangue et au litchi : mise en évidence d'un syndrome de réactivité croisée

Abstract : Introduction: Food allergies to mango and lychee are poorly described, with respectively 12 and 8 case reports in Pubmed. A "pollen-food" syndrome seems to be responsible for these allergies. Few data are available on the type of reaction, the predisposing conditions and the identification of foods at risk of cross-reactivity in the case of food allergy to these fruits. In addition, the place of biological assays and the identification of allergens remain poorly known. Methodology: We performed a retrospective and monocentric analysis of data from 10 outpatients with a food allergy to mango and/or lychee, attending the allergy department from January 2016 to July 2019. Clinical and biological characteristics were studied. A first experimental approach was carried out with Western blot IgE followed by MALDI TOF protein identification. Result: Mango allergy was frequently associated to lychee and celery allergy. Allergic reactions to sunflower seed, fennel and pistachio were reported by some patients. Most patients had a sensitization profile spanning 4 plant families: asteraceae, anacardiaceae, sapindaceae and apiaceae. Allergic rhino-conjunctivitis was frequently found and contrasted with the lack of a known history of food allergy. The sensitivity and specificity of usual specific IgE assays appeared to be low in this context. A homologue of an adenosylhomocysteinase from parsley was identified as a possible allergen of this "pollen-food" syndrome, but confirmation is needed. Conclusion: A link between 4 plant families is highlighted in case of food allergy to mango and/or lychee. A homologous allergen in these families is suspected, possibly represented by an adenosylhomocysteinase.
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https://dumas.ccsd.cnrs.fr/dumas-02514962
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Submitted on : Monday, March 23, 2020 - 10:37:59 AM
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Farid Mankouri. Description clinique, biologique et expérimentale des hypersensibilités immédiates à la mangue et au litchi : mise en évidence d'un syndrome de réactivité croisée. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02514962⟩

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