, Annexe 1 : Liste des dentifrices établie par « agissons ensemble

, Annexe 2 : liste des dentifrices établie par « agissons ensemble

, Voies métaboliques liées à des métabolites différentiels entre les cellules L929 traitées avec des nanoparticules de TiO2 et le groupe témoin, vol.3

Z. Lin, N. A. Monteiro-riviere, and J. E. Riviere, Pharmacokinetics of metallic nanoparticles, Wiley Interdiscip Rev Nanomed Nanobiotechnol, vol.7, pp.189-217, 2015.

A. Usa, Nanomaterials, sunscreens and cosmetics : small ingredients, big risks, 2006.

, Greening Industry and Transport Nanotechnology and Tyres, 2014.

, A research strategy for environmental, health and safety aspects of engieered nanomaterials

, Nanotechnology helps food manufacturers make healthier food, 2012.

S. Gelperina, K. Kisich, M. D. Iseman, L. Heifets, and R. , The Potential Advantages of Nanoparticle Drug Delivery Systems in Chemotherapy of Tuberculosis, Research Center for Molecular Diagnostics and Therapy, 2005.

R. Pandey and G. K. Khuller, Antitubercular inhaled therapy: opportunities, progress and challenges, J Antimicrob Chemother, vol.55, pp.430-435, 2005.

N. Tsapis, D. Bennett, B. Jackson, D. A. Weitz, and D. A. Edwards, Trojan particles: large porous carriers of nanoparticles for drug delivery, Proc Natl Acad Sci, vol.99, pp.12001-12005, 2002.

G. Oberdörster, Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology, J. Int. Med, vol.267, pp.89-105, 2010.

R. Peters, P. Brandhoff, S. Weigel, H. Marvin, H. Bouwmeester et al., Inventory of nanotechnology applications in the agricultural, feed and food sector, 2014.

, Bilan des connaissances relatives aux effets des nanoparticules de dioxyde de titane (TiO2)sur la santé humaine ; caractérisation de l'exposition des populations et mesures de gestion-HSCS Avril, 2018.

V. M. Taavitsainen and J. P. Jalava, Soft and harder multivariate model-ling in developing the properties of titanium dioxide pigments, Chemometr Intell Lab Syst, vol.29, issue.2, pp.307-319, 1995.

D. Sun, T. T. Meng, T. H. Loong, and T. J. Hwa, Removal of natural organic matter from water using a nano-structured photocatalyst coupled with filtrating membrane, Water Sci Technol, vol.49, issue.1, pp.103-110, 2004.

B. Marta, K. Gabriela, O. Marcin, ?. Wies?aw, and M. Wojciech, Singlet oxygen generation in the presence of titanium dioxide materials used as sunscreens in suntan lotions, J Photochem. Photobiol. A, vol.213, issue.2-3, pp.158-163, 2012.

V. Freyre-fonseca, N. L. Delgado-buenrostro, and E. B. Gutierrez-cirlos, Titanium dioxide nanoparticles impair lung mitochondrial function, Toxicol Lett, vol.202, issue.2, pp.111-119, 2011.

, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Lyon, Centre international de recherche sur le cancer, vol.93, pp.193-276, 2010.

S. X. Gui, Z. L. Zhang, and L. Zheng, Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles, J Hazard Mate, vol.195, pp.365-370, 2011.

P. L. Palaniappan and K. S. Pramod, Raman spectroscopic investigation on the microenvironment of the liver tissues of zebrafish (Danio rerio) due to titanium dioxide exposure, Vib Spectrosc, vol.56, issue.2, pp.146-153, 2011.

J. A. Shin, E. J. Lee, S. M. Seo, H. S. Kim, J. L. Kang et al., Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse, Neuroscience, vol.165, issue.2, pp.445-454, 2010.

A. Jaeger, D. G. Weissa, J. L. Kriehuber, and R. , Oxidative stress-induced cytotoxic and genotoxic effects of nano-sized titanium dioxide particles in human HaCaT keratinocytes, Toxicology, vol.296, issue.1-3, pp.27-36, 2012.

. Titane-;-en-ti, Aide-mémoire technique « Les valeurs limites d'exposition professionnelle aux agents chimiques en France

, Current intelligence bulletin 63. Occupational exposure to titanium dioxide, 2011.

D. B. Warheit, S. C. Brown, E. M. Donner, and C. Company,

, Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles, 2015.

A. Lucie, B. Biola-clier-mathilde, C. Laure, D. Véronique, S. Hélène et al., Molecular responses of alveolar epithelial A549 cells to chronic exposure to titanium dioxide nanoparticles: a proteomic view, 2015.

M. Czajka, K. Sawicki, K. Sikorska, and S. Popek, Toxicity of titanium dioxide nanoparticles in central nervous system, 2015.

L. Armand, A. Tarantini, D. Beal, M. Biola-clier, L. Bobyk et al., Long-term exposure of A549 cells to titanium dioxide nanoparticles induces DNA damage and sensitizes cells towards genotoxic agents, 2016.
URL : https://hal.archives-ouvertes.fr/cea-01651136

M. Dorier, D. Béal, C. Marie-desvergne, M. Dubosson, F. Barreau et al., Nathalie Herlin-Boime & Marie Carriere. Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress, 2017.

B. J. Teubl, C. Schimpel, G. Leitinger, B. Bauer, E. Fröhlich et al., Interactions between nano-TiO2 and the oral cavity: Impact of nanomaterial surface hydrophilicity/hydrophobicity, 2015.

D. Sabat, A. Patnaik, and B. Ekka, Priyabrat Dash, Monalisa Mishra. Investigation of titania nanoparticles on behaviour and mechanosensory organ of Drosophila melanogaster, 2016.

Y. Bo, C. Jin, Y. Liu, W. Yu, and H. Kang, Metabolomic analysis on the toxicological effects of TiO2 nanoparticles in mouse fibroblast cells: from the perspective of perturbations in amino acid metabolism, 2014.

D. Dekanski, B. Spremo-potparevi?, V. Baji?, L. ?ivkovi?, D. Topalovi? et al., Acute toxicity study in mice of orally administrated TiO2 nanoparticles functionalized with caffeic, 2018.

, Toxicity of Nano-Titanium Dioxide (TiO2-NP) Through Various Routes of Exposure: a Review, 2015.

J. Schoelermann, A. Burtey, Z. E. Allouni, H. Gerdes, and M. Cimpan, Contact-dependent transfer of TiO2 nanoparticles between mammalian cells, 2015.

F. Hong-yingjun-zhou-xiaoyang-zhao-lei-sheng-ling and W. , Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice, 2017.

I. Magdiel, C. Y. Setyawati, D. T. Tay, and . Leong, Mechanistic Investigation of the Biological Effects of SiO2, TiO2, and ZnO Nanoparticles on Intestinal Cells, 2015.

B. Jovanovic, V. J. Cvetkovic, and T. Lj, Mitrovic. Effects of human food grade titanium dioxide nanoparticle dietary exposure on Drosophila melanogaster survival, fecundity, pupation and expression of antioxidant genes, 2015.

F. Hong, Y. Wang, Y. Zhou, Q. Zhang, Y. Ge et al., Exposure to TiO2 Nanoparticles Induces Immunological Dysfunction in Mouse Testitis, 2015.

M. Ashraf, M. A. Morgan, P. A. Ibrahim, and . Noshy, Reproductive toxicity provoked by titanium dioxide nanoparticles and the ameliorative role of tiron in adult male rats, 2017.

. Efsa-ans-panel, Scientific Opinion on the re-evaluation of titanium dioxide (E 171) as a food additive, EFSA Panel on Food Additives and Nutrient Sources added to Food), vol.14, p.4545, 2016.

, Les nanomatériaux dans l'alimentation. Quelles fonctions et applications ? Quels risques ? Up' Magazine novembre, 2015.

F. Saldmann, Votre santé sans risque, 2017.

C. Larue, C. Baratange, D. Vantelon, H. Khodja, S. Surblé et al., Science of the Total Environment, vol.630, p.609, 2018.

, Environmental hazard of selected TiO2 nanomaterials under consideration of relevant exposure scenarios, Umwelt bundesamt, 2014.

, Avis de l'Anses Saisine, pp.2019-2055

L. Vu, . Président, and . Jury, Signature : Vu, la Directrice de l'UFR des Sciences Odontologiques