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subfield group) (49), permettant une fois mis en place de s'affranchir de l'hétérogénéité importante dans les résultats des études réalisées jusque-là ,
, Par la suite, l'intérêt pourra être multiple avec en premier lieu une meilleure compréhension physiopathologique de la maladie. A ce niveau, il serait intéressant de réaliser une étude longitudinale couplant analyse volumétrique des sous-champs de l'hippocampe et de l'imagerie moléculaire
, L'intérêt pourrait également être à visée diagnostique : l'analyse volumétrique pourrait dans le futur faire partie des critères diagnostiques en tant que biomarqueur de neurodégénerescence de la maladie
, On peut également imaginer que ce protocole de volumétrie soit appliqué chez des sujets à risque afin de détecter le plus précocement ceux ayant un risque plus important de survenue de la maladie, organiser un suivi et pouvoir ralentir le plus tôt possible la maladie avec les moyens dont nous disposons actuellement ou des traitements s'ils viennent à voir le jour. Pour cela, des études sont nécessaires pour mieux définir la corrélation entre la dynamique d'atrophie hippocampique et le déclin cognitif. En effet, dans notre étude
, Pour conclure, il est probable que l'analyse volumétrique des sous-champs de l'hippocampe continue à prendre de l'ampleur dans les années à venir, les objectifs pouvant être multiples, allant d'une meilleure compréhension physiopathologique de la maladie
Comparaison de 21 protocoles de segmentation sur un même sujet, par Yushkevich et al, montrant l'hétérogénéité entre les protocoles. Coupes coronales de la tête de l'hippocampe en haut ,
, Exemples du protocole de segmentation de l'hippocampe utilisé dans cette étude (50), après traitement de l'image
, L'hippocampe est segmenté en trois parties : le Subiculum (vert), la corne d'ammon de CA1 à 3 (rouge) et CA4
, Au moment d'être admis(e) à exercer la médecine, je promets et je jure d'être fidèle aux lois de l'honneur et de la probité
, Mon premier souci sera de rétablir, de préserver ou de promouvoir la santé dans tous ses éléments, physiques et mentaux, individuels et sociaux
, Je respecterai toutes les personnes, leur autonomie et leur volonté, sans aucune discrimination selon leur état ou leurs convictions. J'interviendrai pour les protéger si elles sont affaiblies, vulnérables ou menacées dans leur intégrité ou leur dignité. Même sous la contrainte
, Je ne tromperai jamais leur confiance et n'exploiterai pas le pouvoir hérité des circonstances pour forcer les consciences
, Je ne me laisserai pas influencer par la soif du gain ou la recherche de la gloire
, Reçu(e) à l'intérieur des maisons, je respecterai les secrets des foyers et ma conduite ne servira pas à corrompre les moeurs
, Je ne prolongerai pas abusivement les agonies. Je ne provoquerai jamais la mort délibérément
, Je n'entreprendrai rien qui dépasse mes compétences. Je les entretiendrai et les perfectionnerai pour assurer au mieux les services qui me seront demandés
, J'apporterai mon aide à mes confrères ainsi qu'à leurs familles dans l'adversité
, Que les hommes et mes confrères m'accordent leur estime si je suis fidèle à mes promesses