F. Costa, J. E. Hagan, J. Calcagno, M. Kane, P. Torgerson et al., Global Morbidity and Mortality of Leptospirosis: A Systematic Review, PLoS Negl Trop Dis, vol.9, issue.9, p.3898, 2015.

C. L. Lau, L. D. Smythe, S. B. Craig, and P. Weinstein, Climate change, flooding, urbanisation and leptospirosis: fuelling the fire?, Trans R Soc Trop Med Hyg, vol.104, issue.10, pp.631-639, 2010.

S. Bhatt, P. W. Gething, O. J. Brady, J. P. Messina, A. W. Farlow et al., The global distribution and burden of dengue, Nature. 25 avr, vol.496, issue.7446, pp.504-511, 2013.

C. J. Struchiner, J. Rocklöv, A. Wilder-smith, and E. Massad, Increasing Dengue Incidence in Singapore over the Past 40 Years: Population Growth, Climate and Mobility, PLOS ONE, vol.10, issue.8, p.136286, 2015.

M. Vincent, S. Larrieu, P. Vilain, E. A. Solet, J. François et al., From the threat to the large outbreak: dengue on Reunion Island, Euro Surveill, issue.47, p.24, 2015.

T. Ellis, A. Imrie, A. R. Katz, and P. V. Effler, Underrecognition of Leptospirosis During a Dengue Fever Outbreak in Hawaii, Vector Borne Zoonotic Dis, vol.8, issue.4, pp.541-548, 2001.

L. Turnier, P. Bonifay, T. Mosnier, E. Schaub, R. Jolivet et al., Usefulness of C-Reactive Protein in Differentiating Acute Leptospirosis and Dengue Fever in French Guiana, Open Forum Infect Dis. 1 sept, vol.6, issue.9, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02862875

B. Mishra, L. Singhal, S. Sethi, and R. K. Ratho, Leptospirosis Coexistent with Dengue Fever: A Diagnostic Dilemma, J Glob Infect Dis, vol.5, issue.3, pp.121-123, 2013.

D. H. Libraty, K. Myint, C. K. Murray, R. V. Gibbons, M. P. Mammen et al., A Comparative Study of Leptospirosis and Dengue in Thai Children, PLoS Negl Trop Dis, vol.1, issue.3, 2007.

B. Flannery, M. M. Pereira, F. Velloso-l-de, C. Carvalho-c-de, D. Codes et al., Referral pattern of leptospirosis cases during a large urban epidemic of dengue, Am J Trop Med Hyg, vol.65, issue.5, pp.657-63, 2001.

M. G. Bruce, E. J. Sanders, J. Leake, .. D. Zaidel, O. Bragg et al., Leptospirosis among patients presenting with dengue-like illness in Puerto Rico, Acta Trop, vol.96, issue.1, pp.36-46, 2005.

D. A. Muller, A. Depelsenaire, and P. R. Young, Clinical and Laboratory Diagnosis of Dengue Virus Infection, J Infect Dis. 1 mars, vol.215, issue.suppl_2, pp.89-95, 2017.

N. Temeiam, S. Jareinpituk, P. Phinyo, J. Patumanond, and N. Srisawat, Development and Validation of a simple score for diagnosis of Leptospirosis at outpatient departments, PLoS Negl Trop Dis. janv, vol.14, issue.1, p.7977, 2020.

M. Trunfio, A. Savoldi, O. Viganò, D. Monforte, and A. , Bacterial coinfections in dengue virus disease: what we know and what is still obscure about an emerging concern, Infection. févr, vol.45, issue.1, pp.1-10, 2017.

S. N. Alia, N. Joseph, N. Philip, N. N. Azhari, B. Garba et al., Diagnostic accuracy of rapid diagnostic tests for the early detection of leptospirosis, J Infect Public Health. avr, vol.12, issue.2, pp.263-272, 2019.

. Vi and . References,

, Leptospirosis: Updating the Global Picture of an Emerging Neglected Disease, WHO | Neglected tropical diseases. Disponible sur, vol.9, 2015.

Z. Soo, N. A. Khan, and R. Siddiqui, Leptospirosis: Increasing importance in developing countries, Acta Trop, vol.201, p.105183, 2020.

S. Bhatt, P. W. Gething, O. J. Brady, J. P. Messina, A. W. Farlow et al., The global distribution and burden of dengue, Nature. 25 avr, vol.496, issue.7446, pp.504-511, 2013.

A. Wilder-smith, E. Ooi, O. Horstick, B. Wills, and . Dengue, Lancet, vol.26, pp.350-63, 2019.

D. A. Haake and P. N. Levett, Leptospirosis in humans, Curr Top Microbiol Immunol, vol.387, pp.65-97, 2015.

A. I. Ko, G. Reis, M. , R. Dourado, C. M. Johnson et al., Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group. Lancet. 4 sept, vol.354, pp.820-825, 1999.

R. C. Larocque, R. F. Breiman, M. D. Ari, R. E. Morey, F. A. Janan et al., Leptospirosis during Dengue Outbreak, Bangladesh. Emerg Infect Dis. mai, vol.11, issue.5, pp.766-775, 2005.

T. Ellis, A. Imrie, A. R. Katz, and P. V. Effler, Underrecognition of Leptospirosis During a Dengue Fever Outbreak in Hawaii, Vector Borne Zoonotic Dis. août, vol.8, issue.4, pp.541-548, 2001.

M. G. Brown, I. E. Vickers, R. A. Salas, and M. F. Smikle, Leptospirosis in suspected cases of dengue in

. Jamaica, Trop Doct. avr, vol.40, issue.2, pp.92-96, 2002.

B. Flannery, M. M. Pereira, F. Velloso-l-de, C. Carvalho-c-de, D. Codes et al., Referral pattern of leptospirosis cases during a large urban epidemic of dengue, Am J Trop Med Hyg, vol.65, issue.5, pp.657-63, 2001.

P. N. Levett, S. L. Branch, and C. N. Edwards, Detection of dengue infection in patients investigated for leptospirosis in Barbados, Am J Trop Med Hyg. janv, vol.62, issue.1, pp.112-116, 2000.

M. G. Bruce, E. J. Sanders, J. Leake, .. D. Zaidel, O. Bragg et al., Leptospirosis among patients presenting with dengue-like illness in Puerto Rico, Acta Trop, vol.96, issue.1, pp.36-46, 2005.

F. Pagès, D. Polycarpe, J. Dehecq, M. Picardeau, N. Caillère et al.,

, Human Leptospirosis on Reunion Island: Past and Current Burden. Int J Environ Res Public Health. janv, vol.11, issue.1, pp.968-82, 2014.

M. Vincent, S. Larrieu, P. Vilain, E. A. Solet, J. François et al., From the threat to the large outbreak: dengue on Reunion Island, Euro Surveill, vol.24, issue.47, 2015.

. Dengue-À-la-réunion, Poursuite de l'augmentation du nombre de cas hebdomadaire

A. Tarantola and C. Goarant, Leptospirosis in French Historical Medical Literature: Weil's Disease or Kelsch's Disease?, Am J Trop Med Hyg, vol.99, issue.6, pp.1366-1374, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01892998

A. M. Stimson, Note on an organism found in yellow-fever tissue, Public Health Reports, pp.1896-1970, 1907.

P. Bourhy, P. Hochedez, M. Picardeau, and . Leptospirose, EMC Maladies infectieuses, 2012.

P. Bourhy, L. Collet, S. Brisse, and M. Picardeau, Leptospira mayottensis sp. nov., a pathogenic species of the genus Leptospira isolated from humans, Int J Syst Evol Microbiol. déc, vol.64, pp.4061-4068, 2014.

P. N. Levett and . Leptospirosis, Clin Microbiol Rev. avr, vol.14, issue.2, pp.296-326, 2001.

, Ko: Leptospira: the dawn of the molecular genetics, Nat Rev Microbiol, vol.7, issue.10, pp.736-783, 2009.

E. Bertherat and . Éditorial, La leptospirose: une maladie émergente ou un problème émergent ?, Bull Epidémiol Hebd, issue.8-9, p.130, 2017.

F. Costa, J. E. Hagan, J. Calcagno, M. Kane, P. Torgerson et al., Global Morbidity and Mortality of Leptospirosis: A Systematic Review, PLoS Negl Trop Dis, vol.9, issue.9, p.3898, 2015.

L. Turnier, P. Epelboin, and L. , Update on leptospirosis, Rev Med Interne. mai, vol.40, issue.5, pp.306-318, 2019.

M. Jensenius, P. V. Han, P. Schlagenhauf, E. Schwartz, P. Parola et al., Acute and potentially life-threatening tropical diseases in western travelers--a GeoSentinel multicenter study, Am J Trop Med Hyg. févr, vol.88, issue.2, pp.397-404, 1996.

F. Pagès, B. Kurtkowiak, M. C. Jaffar-bandjee, J. Jaubert, F. Domonte et al.,

, Épidémiologie de la leptospirose à La Réunion, Bull Epidémiol Hebd, issue.8-9, pp.137-183, 2004.

A. Victoriano, L. D. Smythe, N. Gloriani-barzaga, L. L. Cavinta, T. Kasai et al., Leptospirosis in the Asia Pacific region, BMC Infect Dis. 4 sept, vol.9, p.147, 2009.

B. Cacciapuoti, L. Ciceroni, A. Pinto, M. Apollini, V. Rondinella et al., Survey on the prevalence of leptospira infections in the Italian population, Eur J Epidemiol. 1 avr, vol.10, issue.2, pp.173-80, 1994.

A. Jansen, K. Stark, T. Schneider, and I. Schöneberg, Sex differences in clinical leptospirosis in Germany, Clin Infect Dis. 1 mai, vol.44, issue.9, pp.69-72, 1997.

J. Skufca and Y. Arima, Sex, gender and emerging infectious disease surveillance: a leptospirosis case study, Western Pac Surveill Response J. 2 août, vol.3, issue.3, pp.37-46, 2012.

M. Picardeau, Virulence of the zoonotic agent of leptospirosis: still terra incognita?, Nat Rev Microbiol, vol.15, issue.5, pp.297-307, 2017.

B. Adler, Pathogenesis of leptospirosis: cellular and molecular aspects, Vet Microbiol. 27 août, vol.172, issue.3-4, pp.353-361, 2014.

T. R. Fraga, D. Courrol, M. M. Castiblanco-valencia, I. Y. Hirata, S. A. Vasconcellos et al., Immune evasion by pathogenic Leptospira strains: the secretion of proteases that directly cleave complement proteins, J Infect Dis. mars, vol.209, issue.6, pp.876-86, 2014.

J. Lingappa, T. Kuffner, J. Tappero, W. Whitworth, A. Mize et al., HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis, Genes Immun. mai, vol.5, issue.3, pp.197-202, 2004.

D. Brito, T. Da-silva, A. Abreu, and P. , Pathology and pathogenesis of human leptospirosis: a commented review, Rev Inst Med Trop Sao Paulo. 28 mai, 2018.

E. Daher, K. De-abreu, S. Da, and G. B. Junior, Leptospirosis-associated acute kidney injury

, J Bras Nefrol. déc, vol.32, issue.4, pp.400-407, 2010.

S. Miyahara, M. Saito, T. Kanemaru, S. Villanueva, N. G. Gloriani et al., Destruction of the hepatocyte junction by intercellular invasion of Leptospira causes jaundice in a hamster model of Weil's disease, Int J Exp Pathol. août, vol.95, issue.4, pp.271-81, 2014.

C. Werts, R. I. Tapping, J. C. Mathison, T. H. Chuang, V. Kravchenko et al.,

, Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism, Nat Immunol. avr, vol.2, issue.4, pp.346-52, 2001.

V. Guernier, E. Lagadec, C. Cordonin, L. Minter, G. Gomard et al., Are Rodents the (Only) Ones to Blame?, Human Leptospirosis on Reunion Island, vol.10, issue.6, p.4733, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01371145

W. A. Ellis, Animal leptospirosis, Curr Top Microbiol Immunol, vol.387, pp.99-137, 2015.

K. Woods, C. Nic-fhogartaigh, C. Arnold, L. Boutthasavong, W. Phuklia et al., A comparison of two molecular methods for diagnosing leptospirosis from three different sample types in patients presenting with fever in Laos, Clin Microbiol Infect. sept, vol.24, issue.9, 2014.

F. Paganin, A. Bourdin, G. Borgherini, C. Dalban, P. Poubeau et al., Pulmonary manifestations of leptospirosis, Rev Mal Respir, vol.26, issue.9, pp.971-980, 2009.

A. R. Bharti, J. E. Nally, J. N. Ricaldi, M. A. Matthias, M. M. Diaz et al., Leptospirosis: a zoonotic disease of global importance, Lancet Infect Dis. déc, vol.3, issue.12, pp.757-71, 2003.

A. J. Taylor, D. H. Paris, and P. N. Newton, A Systematic Review of the Mortality from Untreated Leptospirosis, PLoS Negl Trop Dis, vol.9, issue.6, p.3866, 2015.

H. Dupont, D. Dupont-perdrizet, J. L. Perie, S. Zehner-hansen, B. Jarrige et al.,

, Leptospirosis: prognostic factors associated with mortality, Clin Infect Dis. sept, vol.25, issue.3, pp.720-724, 1997.

T. Panaphut, S. Domrongkitchaiporn, and B. Thinkamrop, Prognostic factors of death in leptospirosis: a prospective cohort study in Khon Kaen, Thailand, Int J Infect Dis. mars, vol.6, issue.1, pp.52-61, 2002.

D. M. Brett-major and R. Coldren, Antibiotics for leptospirosis, Cochrane Database Syst Rev. 15 févr, issue.2, p.8264, 2012.

C. Herrmann-storck, S. Louis, M. Foucand, T. Lamaury, I. Deloumeaux et al.,

, Severe Leptospirosis in Hospitalized Patients, Guadeloupe. Emerg Infect Dis. févr, vol.16, issue.2, pp.331-335, 2010.

N. Lee, E. Kitashoji, N. Koizumi, T. Lacuesta, M. R. Ribo et al., Building prognostic models for adverse outcomes in a prospective cohort of hospitalised patients with acute leptospirosis infection in the Philippines, Trans R Soc Trop Med Hyg, vol.01, issue.12, pp.531-540, 2017.

S. Tubiana, M. Mikulski, J. Becam, F. Lacassin, P. Lefèvre et al., Risk Factors and Predictors of Severe Leptospirosis in New Caledonia, PLoS Negl Trop Dis. 10 janv, vol.7, issue.1, 2013.
URL : https://hal.archives-ouvertes.fr/pasteur-00787389

, Human leptospirosis: guidance for diagnosis, surveillance and control, World Health Organization, 2003.

B. Delmas, J. Jabot, P. Chanareille, C. Ferdynus, A. J. Allou et al., Leptospirosis in ICU: A Retrospective Study of 134 Consecutive Admissions, Crit Care Med, vol.46, issue.1, pp.93-102, 2018.

A. Miailhe, E. Mercier, A. Maamar, J. Lacherade, L. Thuaut et al., Severe leptospirosis in non-tropical areas: a nationwide, multicentre, retrospective study in French ICUs, Intensive Care Med, vol.45, issue.12, pp.1763-73, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02465751

L. Haake, Gouveia: Leptospirosis-associated severe pulmonary hemorrhagic syndrome, Curr Top Microbiol Immunol, vol.387, issue.3, pp.505-513, 2008.

. Ressner, Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira, Antimicrob Agents Chemother, vol.52, issue.8, pp.2750-2754, 2008.

C. Rodrigo, N. Lakshitha-de-silva, R. Goonaratne, K. Samarasekara, I. Wijesinghe et al., High dose corticosteroids in severe leptospirosis: a systematic review, Trans R Soc Trop Med Hyg. déc, vol.108, issue.12, pp.743-50, 2014.

. Leptospirose and F. Santé-publique, Disponible sur : /maladies-et-traumatismes/maladies-a

D. J. Gubler, Dengue and Dengue Hemorrhagic Fever, Clin Microbiol Rev. juill, vol.11, issue.3, pp.480-96, 1998.

J. D. Stanaway, D. S. Shepard, E. A. Undurraga, Y. A. Halasa, L. E. Coffeng et al., The global burden of dengue: an analysis from the Global Burden of Disease Study, Lancet Infect Dis, vol.16, issue.6, pp.712-735, 2013.

. Oliver-j-brady-1, W. Peter, S. Gething, J. P. Bhatt, J. S. Messina et al., Refining the Global Spatial Limits of Dengue Virus Transmission by Evidence-Based Consensus, PLoS Negl Trop Dis, vol.6, issue.8, pp.1760-2012

D. Glaesser, J. Kester, H. Paulose, A. Alizadeh, and B. Valentin, Global travel patterns: an overview, J Travel Med, vol.01, issue.4, 2017.

L. Rosen, Dengue in Greece in 1927 and 1928 and the pathogenesis of dengue hemorrhagic fever: new data and a different conclusion, Am J Trop Med Hyg. mai, vol.35, issue.3, pp.642-53, 1986.

E. Schwartz, L. H. Weld, A. Wilder-smith, V. Sonnenburg, F. Keystone et al.,

, Seasonality, annual trends, and characteristics of dengue among ill returned travelers, Emerging Infect Dis. juill, vol.14, issue.7, pp.1081-1089, 1997.

E. Massad, M. Amaku, F. Coutinho, C. J. Struchiner, M. N. Burattini et al., Estimating the probability of dengue virus introduction and secondary autochthonous cases in, Europe. Sci Rep, vol.15, issue.1, p.4629, 2018.

. Chikungunya, Santé publique France. 69. Rapid risk assessment: Dengue outbreak in Réunion, France, and associated risk of autochthonous outbreak in the EU/EEA. European Centre for Disease Prevention and Control, 2019.

L. Alves, Honduras's worst dengue outbreak in 50 years. The Lancet. 3 août, vol.394, p.371, 2019.

C. J. Struchiner, J. Rocklöv, A. Wilder-smith, and E. Massad, Increasing Dengue Incidence in Singapore over the Past 40 Years: Population Growth, Climate and Mobility, PLOS ONE. 31 août, vol.10, issue.8, p.136286, 2015.

V. Kles, A. Michault, F. Rodhain, F. Mevel, and C. Chastel,

, Flaviviridae infections on the island of Réunion, 1971.

, Bull Soc Pathol Exot, vol.87, issue.2, pp.71-77, 1994.

S. Larrieu, J. S. Dehecq, E. Balleydier, M. C. Jaffar, A. Michault et al., Re-emergence of dengue in Reunion, Euro Surveill. 17 mai, vol.17, 1920.

S. Larrieu, A. Michault, D. Polycarpe, F. Schooneman, D. 'ortenzio et al., Dengue outbreaks: a constant risk for Reunion Island. Results from a seroprevalence study among blood donors, Trans R Soc Trop Med Hyg. janv, vol.108, issue.1, pp.57-66, 2014.

P. Renault, J. Solet, D. Sissoko, E. Balleydier, S. Larrieu et al., A major epidemic of chikungunya virus infection on Reunion Island, Am J Trop Med Hyg, vol.77, issue.4, pp.727-758, 2005.

G. E. Snow, B. Haaland, E. E. Ooi, and D. J. Gubler, Review article: Research on dengue during World War II revisited, Am J Trop Med Hyg. déc, vol.91, issue.6, pp.1203-1220, 2014.

M. Montoya, L. Gresh, J. C. Mercado, K. L. Williams, M. J. Vargas et al., Symptomatic versus inapparent outcome in repeat dengue virus infections is influenced by the time interval between infections and study year, PLoS Negl Trop Dis, vol.7, issue.8, p.2357, 2013.

K. B. Anderson, R. V. Gibbons, D. Cummings, A. Nisalak, S. Green et al., A shorter time interval between first and second dengue infections is associated with protection from clinical illness in a school-based cohort in Thailand, J Infect Dis. 1 févr, vol.209, issue.3, pp.360-368, 2014.

M. G. Guzman, S. B. Halstead, H. Artsob, P. Buchy, J. Farrar et al., Dengue: a continuing global threat, Nat Rev Microbiol. déc, vol.8, issue.12, pp.7-16, 2010.

E. Z. Ong, S. L. Zhang, H. C. Tan, E. S. Gan, K. R. Chan et al., Dengue virus compartmentalization during antibody-enhanced infection, Sci Rep, vol.13, p.40923, 2017.

A. L. Rothman, Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms, Nat Rev Immunol. 15 juill, vol.11, issue.8, pp.532-575, 2011.

S. Yacoub, H. Wertheim, C. P. Simmons, G. Screaton, and B. Wills, Microvascular and endothelial function for risk prediction in dengue: an observational study, Lancet. 26 févr, vol.385, 2015.

L. C. Katzelnick, M. Montoya, L. Gresh, A. Balmaseda, and E. Harris, Neutralizing antibody titers against dengue virus correlate with protection from symptomatic infection in a longitudinal cohort, Proc Natl Acad Sci, vol.113, issue.3, pp.728-761, 2016.

M. Ohainle, A. Balmaseda, A. R. Macalalad, Y. Tellez, M. C. Zody et al., Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity, Sci Transl Med. 21 déc, vol.3, issue.114, pp.114-128, 2011.

J. M. Mackenzie, M. K. Jones, and P. R. Young, Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication, Virology. 1 juin, vol.220, issue.1, pp.232-272, 1996.

G. Pare, B. Neupane, S. Eskandarian, E. Harris, S. Halstead et al., Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries, EBioMedicine. janv, vol.51, p.102584, 2020.

V. Duong, L. Lambrechts, R. E. Paul, S. Ly, R. S. Lay et al., Asymptomatic humans transmit dengue virus to mosquitoes, Proc Natl Acad Sci, vol.112, issue.47, pp.14688-93, 2015.
URL : https://hal.archives-ouvertes.fr/pasteur-01239113

N. M. Nguyen, Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes, Proc Natl Acad Sci U S A, vol.110, issue.22, pp.9072-9077, 2013.

T. P. Endy, K. B. Anderson, A. Nisalak, I. Yoon, S. Green et al., Determinants of Inapparent and Symptomatic Dengue Infection in a Prospective Study of Primary School Children in Kamphaeng Phet, PLOS Neglected Tropical Diseases. 1 mars, vol.5, issue.3, p.975, 2011.

S. H. Pouliot, X. Xiong, E. Harville, V. Paz-soldan, K. M. Tomashek et al., Maternal dengue and pregnancy outcomes: a systematic review, Obstet Gynecol Surv. févr, vol.65, issue.2, pp.107-125, 2010.

C. H. Liew, The first case of sexual transmission of dengue in Spain, J Travel Med, 2019.

M. Trpis, G. A. Mcclelland, J. D. Gillett, C. Teesdale, and T. R. Rao, Diel periodicity in the landing of Aedes aegypti on man, Bull World Health Organ. mai, vol.48, issue.5, pp.623-632, 1973.

, World Health Organization. Dengue and severe dengue

J. M. Medlock, D. Avenell, I. Barrass, and S. Leach, Analysis of the potential for survival and seasonal activity of Aedes albopictus (Diptera: Culicidae) in the United Kingdom, J Vector Ecol. déc, vol.31, issue.2, pp.292-304, 2006.

H. Delatte, G. Gimonneau, A. Triboire, and D. Fontenille, Influence of temperature on immature development, survival, longevity, fecundity, and gonotrophic cycles of Aedes albopictus, vector of chikungunya and dengue in the Indian Ocean, J Med Entomol. janv, vol.46, issue.1, pp.33-41, 2009.

L. Bagny-beilhe, H. Delatte, S. A. Juliano, D. Fontenille, and S. Quilici, Ecological interactions in Aedes species on Reunion Island, Med Vet Entomol. déc, vol.27, issue.4, pp.387-97, 2013.

L. Bagny, H. Delatte, S. Quilici, and D. Fontenille, Progressive decrease in Aedes aegypti distribution in Reunion Island since the 1900s, J Med Entomol, vol.46, issue.6, pp.1541-1546, 2009.

E. A. Hunsperger, S. Yoksan, P. Buchy, V. C. Nguyen, S. D. Sekaran et al., Evaluation of commercially available diagnostic tests for the detection of dengue virus NS1 antigen and anti-dengue virus IgM antibody, PLoS Negl Trop Dis, vol.8, issue.10, p.3171, 2014.

D. Gyurech, J. Schilling, J. Schmidt-chanasit, P. Cassinotti, F. Kaeppeli et al., False positive dengue NS1 antigen test in a traveller with an acute Zika virus infection imported into Switzerland, Swiss Med Wkly, vol.146, p.14296, 2016.

P. K. Lam, D. Tam, T. V. Diet, C. T. Tam, N. Tien et al., Clinical characteristics of Dengue shock syndrome in Vietnamese children: a 10-year prospective study in a single hospital, Clin Infect Dis. déc, vol.57, issue.11, pp.1577-86, 2013.

J. Low, E. E. Ooi, and S. G. Vasudevan, Current Status of Dengue Therapeutics Research and Development, J Infect Dis. 1 mars, vol.215, issue.suppl_2, pp.96-102, 2017.

X. Lim, C. Shan, J. K. Marzinek, H. Dong, T. S. Ng et al., Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C, PLOS Pathogens, vol.15, issue.9, p.1007996, 2019.

, Place du vaccin Dengvaxia® dans la stratégie de lutte contre la dengue dans les départements français d'Outre-mer-L'île de La Réunion

S. Gulati and A. Maheshwari, Dengue fever-like illnesses: how different are they from each other?, Scand J Infect Dis. juill, vol.44, issue.7, pp.522-552, 2012.

L. Turnier, P. Mosnier, E. Schaub, R. Bourhy, P. Jolivet et al., Epidemiology of Human Leptospirosis in French Guiana (2007-2014): A Retrospective Study, Am J Trop Med Hyg, vol.99, issue.3, pp.590-596, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-01868796

P. Renault, E. Boidin, D. 'ortenzio, E. Balleydier, E. Daniel et al., possible impact de l'épidémie de chikungunya sur la létalité de la leptospirose, Bull Soc Pathol Exot. 1 mai, vol.104, issue.2, pp.148-52, 2004.

, Surveillance sanitaire de la leptospirose à la Réunion. Point épidémiologique au 15 avril 2019. Le point épidémio | Leptospirose à La Réunion Bilan, 2018.

D. Deodhar and M. John, Leptospirosis: experience at a tertiary care hospital in northern India, Natl Med J India. avr, vol.24, issue.2, pp.78-80, 2011.

A. Sachu, A. Madhavan, A. Vasudevan, and J. Vasudevapanicker, Prevalence of dengue and leptospirosis co-infection in a tertiary care hospital in south India, Iran J Microbiol. août, vol.10, issue.4, pp.227-259, 2018.

M. Hishamshah, N. Ahmad, M. Ibrahim, H. , N. Halim et al.,

, Demographic, clinical and laboratory features of leptospirosis and dengue co-infection in Malaysia, J Med Microbiol. juin, vol.67, issue.6, pp.806-819, 2018.

M. Trunfio, A. Savoldi, O. Viganò, D. Monforte, and A. , Bacterial coinfections in dengue virus disease: what we know and what is still obscure about an emerging concern, Infection. févr, vol.45, issue.1, pp.1-10, 2017.

T. Thein, D. C. Lye, Y. Leo, J. Wong, Y. Hao et al., Severe neutropenia in dengue patients: prevalence and significance, Am J Trop Med Hyg. juin, vol.90, issue.6, pp.984-991, 2014.

S. Mullan and T. H. Panwala, Polymerase Chain Reaction: An Important Tool for Early Diagnosis of Leptospirosis Cases, J Clin Diagn Res. déc, vol.10, issue.12, pp.8-11, 2016.

A. Slack, M. Symonds, M. Dohnt, C. Harris, D. Brookes et al., Evaluation of a modified Taqman assay detecting pathogenic Leptospira spp. against culture and Leptospira-specific IgM enzyme-linked immunosorbent assay in a clinical environment, Diagn Microbiol Infect Dis. avr, vol.57, issue.4, pp.361-367, 2007.

, Human leptospirosis: guidance for diagnosis, surveillance and control. Rev Inst Med trop S Paulo, vol.45, pp.292-292, 2003.

, Diagnostic biologique direct précoce de la dengue par détection génomique du virus avec RT-PCR (transcription inverse et amplification génique par réaction de polymérisation en chaîne)

S. D. Blacksell, R. G. Jarman, M. S. Bailey, A. Tanganuchitcharnchai, K. Jenjaroen et al., Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy, Clin Vaccine Immunol. déc, vol.18, issue.12, pp.2095-101, 2011.

M. Goris, M. Leeflang, M. Loden, J. Wagenaar, P. R. Klatser et al., Prospective evaluation of three rapid diagnostic tests for diagnosis of human leptospirosis, PLoS Negl Trop Dis, vol.7, issue.7, p.2290, 2013.

M. Picardeau, E. Bertherat, M. Jancloes, A. N. Skouloudis, K. Durski et al., Rapid tests for diagnosis of leptospirosis: current tools and emerging technologies, Diagn Microbiol Infect Dis. janv, vol.78, issue.1, pp.1-8, 2014.

K. Bandara, M. M. Weerasekera, C. Gunasekara, N. Ranasinghe, C. Marasinghe et al., Utility of modified Faine's criteria in diagnosis of leptospirosis, BMC Infect Dis. 24 août, vol.16, issue.1, 2016.

J. A. Potts and A. L. Rothman, Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations, Trop Med Int Health, vol.13, issue.11, pp.1328-1368, 2008.

M. D. Varma, S. Vengalil, S. Vallabhajosyula, P. C. Krishnakumar, and S. Vidyasagar, Leptospirosis and dengue fever: a predictive model for early differentiation based on clinical and biochemical parameters, Trop Doct. avr, vol.44, issue.2, pp.100-102, 2014.

D. H. Libraty, K. Myint, C. K. Murray, R. V. Gibbons, M. P. Mammen et al., A Comparative Study of Leptospirosis and Dengue in Thai Children, PLoS Negl Trop Dis, vol.26, 2007.

S. A. Zaki and P. Shanbag, Clinical manifestations of dengue and leptospirosis in children in Mumbai: an observational study, Infection. août, vol.38, issue.4, pp.285-91, 2010.

L. Turnier, P. Bonifay, T. Mosnier, E. Schaub, R. Jolivet et al., Usefulness of C-Reactive Protein in Differentiating Acute Leptospirosis and Dengue Fever in French Guiana, Open Forum Infect Dis. 1 sept, vol.6, issue.9, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02862875

S. Rajapakse, P. Weeratunga, R. Niloofa, N. Fernando, N. L. De-silva et al., A Diagnostic Scoring Model for Leptospirosis in Resource Limited Settings, PLoS Negl Trop Dis, vol.10, issue.6, p.4513, 2016.

T. Sukmark, N. Lumlertgul, S. Peerapornratana, K. Khositrangsikun, K. Tungsanga et al., Thai-Lepto-on-admission probability (THAI-LEPTO) score as an early tool for initial diagnosis of leptospirosis: Result from Thai-Lepto AKI study group, PLoS Negl Trop Dis, vol.12, issue.3, 2018.

, Hypocalcemia, hypochloremia, and eosinopenia as clinical predictors of leptospirosis: A retrospective study, J Infect Public Health. févr, vol.13, issue.2, pp.216-236, 2020.

M. Shao, G. Li, K. Sarvottam, S. Wang, C. Thongprayoon et al., Dyschloremia Is a Risk Factor for the Development of Acute Kidney Injury in Critically Ill Patients, PLoS ONE, vol.11, issue.8, p.160322, 2016.

D. A. Muller, A. Depelsenaire, and P. R. Young, Clinical and Laboratory Diagnosis of Dengue Virus Infection, J Infect Dis. 1 mars, vol.215, issue.suppl_2, pp.89-95, 2017.

N. Issa, O. Guisset, G. Mourissoux, C. Gabinski, and F. Camou, Leptospirose et thrombopénie. La revue de médecine interne, 2015.

. Oliveira-ecl-de, E. Pontes, R. V. Cunha, . Da, I. B. Fróes et al., Hematological abnormalities in patients with dengue, Rev Soc Bras Med Trop. déc, vol.42, issue.6, pp.682-687, 2009.

M. Malathesha, Hematological manifestations in dengue fever -an observational study, Journal of Evolution of Medical and Dental Sciences, vol.3, issue.9, pp.2245-2250, 2014.

T. Sargeant, T. Harris, R. Wilks, S. Barned, K. Galloway-blake et al., Rhabdomyolysis and Dengue Fever: A Case Report and Literature Review. Case Rep Med, 2013.

J. Wagenaar, M. Goris, D. L. Partiningrum, B. Isbandrio, R. A. Hartskeerl et al., Coagulation disorders in patients with severe leptospirosis are associated with severe bleeding and mortality, Trop Med Int Health. févr, vol.15, issue.2, pp.152-161, 2010.

B. Wills, V. N. Tran, T. Nguyen, T. Truong, T. Tran et al., Hemostatic changes in Vietnamese children with mild dengue correlate with the severity of vascular leakage rather than bleeding, Am J Trop Med Hyg, vol.81, issue.4, pp.638-682, 2009.

E. Balleydier, G. Camuset, C. Socolovschi, M. Moiton, B. Kuli et al., Emerg Infect Dis. févr, vol.21, issue.2, pp.316-325, 2011.

X. Cheng, X. Pu, P. Jun, X. Zhu, D. Zhu et al., Rapid and quantitative detection of C-reactive protein using quantum dots and immunochromatographic test strips, Int J Nanomedicine. 2 déc, vol.9, pp.5619-5645, 2014.

. Viii and . Serment-d'hippocrate, Au moment d'être admis à exercer la médecine, je promets et je jure d'être fidèle aux lois de l'honneur et de la probité

, Mon premier souci sera de rétablir, de préserver ou de promouvoir la santé dans tous ses éléments, physiques et mentaux, individuels et sociaux

, Je respecterai toutes les personnes, leur autonomie et leur volonté, sans aucune discrimination selon leur état ou leurs convictions. J'interviendrai pour les protéger si elles sont affaiblies, vulnérables ou menacées dans leur intégrité ou leur dignité. Même sous la contrainte

, Je ne tromperai jamais leur confiance et n'exploiterai pas le pouvoir hérité des circonstances pour forcer les consciences. Je donnerai mes soins à l'indigent et à quiconque me les demandera, J'informerai les patients des décisions envisagées, de leurs raisons et de leurs conséquences

, Reçu à l'intérieur des maisons, je respecterai les secrets des foyers et ma conduite ne servira pas à corrompre les moeurs. Je ferai tout pour soulager les souffrances, je ne prolongerai pas abusivement les agonies

, Je n'entreprendrai rien qui dépasse mes compétences. Je les entretiendrai et les perfectionnerai pour assurer aux mieux les services qui me seront demandés

, J'apporterai mon aide à mes confrères ainsi qu'à leurs familles dans l'adversité. Que les hommes et mes confrères m'accordent leur estime si je suis fidèle à mes promesses