P. D. Marsh, M. V. Martin, M. Lewis, and D. Williams, Oral Microbiology E-Book, vol.232, 2009.

F. Simain, E. Rompen, and E. Heinen, Biofilms bactériens et médecine dentaire, Rev Med Liège, vol.5, pp.569-573, 2010.

C. Mouton, J. Robert, J. Sixou, and L. Trahan, Bactériologie bucco-dentaire, 1994.

P. D. Marsh, Dental Plaque as a Microbial Biofilm, Caries Res, vol.38, issue.3, pp.204-215, 2004.

, Comment se développe l'inflammation gingivale

, médicale (Inserm) I national de la santé et de la recherche, Maladies parodontales : Thérapeutiques et prévention

, Les éditions Inserm, 1999.

, Inserm) I national de la santé et de la recherche, Maladies parodontales : Thérapeutiques et prévention

, Les éditions Inserm, 1999.

C. Badet and B. Richard, Étude clinique de la carie, EMC Dent. févr, vol.1, issue.1, pp.40-48, 2004.

P. Lesclous, Prescription des antibiotiques en pratique bucco-dentaire: Recommandations Afssaps, vol.17, pp.334-380, 2011.

R. H. Selwitz, A. I. Ismail, and N. B. Pitts, Dental caries. The Lancet, janv, vol.369, issue.9555, pp.51-60, 2007.

P. H. Keyes, Dental caries in the Syrian bamster. VIII. The induction of rampant caries activity in albino and golden animals, J Dent Res. juin, vol.38, issue.3, pp.525-558, 1959.

E. Newbrun and . Cariology, Baltimore: Williams & Wilkins, 1978.

F. Fioretti and Y. Haïkel, Carie et sucres: Caries and sugars. Médecine Mal Métaboliques, vol.4, pp.543-552, 2010.

H. Youssef, Thérapeutique étiopathogénique de la carie dentaire -EM|consulte. In: Encyclopédie médico-chirurgicale

E. Scientifiques-et-médicales-elsevier and S. Paris, , p.21, 2001.

O. Fejerskov, Changing paradigms in concepts on dental caries: consequences for oral health care, Caries Res. juin, vol.38, issue.3, pp.182-91, 2004.

A. Jose, A. Butler, D. Payne, R. Maclure, P. Rimmer et al., A randomised clinical study to evaluate the efficacy of alcohol-free or alcohol-containing mouthrinses with chlorhexidine on gingival bleeding, Br Dent J. août, vol.219, issue.3, pp.125-155, 2015.

T. Walsh, H. V. Worthington, A. Glenny, V. C. Marinho, and A. Jeroncic, Fluoride toothpastes of different concentrations for preventing dental caries. Cochrane Database Syst Rev, 2019.

J. Liu, J. Ling, K. Zhang, L. Huo, and Y. Ning, Effect of sodium fluoride, ampicillin, and chlorhexidine on Streptococcus mutans biofilm detachment, Antimicrob Agents Chemother. août, vol.56, issue.8, pp.4532-4537, 2012.

C. Sicca, E. Bobbio, N. Quartuccio, G. Nicolò, and A. Cistaro, Prevention of dental caries: A review of effective treatments, J Clin Exp Dent. déc, vol.8, issue.5, pp.604-614, 2016.

, UFSBD -Union Francaise pour la Santé Bucco-Dentaire

E. Varoni, M. Tarce, G. Lodi, and C. A. Chlorhexidine, CHX) in dentistry: state of the art, Minerva Stomatol. sept, vol.61, issue.9, pp.399-419, 2012.

, Définitions : apithérapie -Dictionnaire de français Larousse

C. Habryka, M. Kruczek, and B. Dryga?, Bee products used in apitherapy, World Sci News. mai, issue.48, pp.254-262, 2016.

A. K. Kuropatnicki, E. Szliszka, and W. Krol, Historical aspects of propolis research in modern times, Evid-Based Complement Altern Med ECAM. avr, p.964149, 2013.

L. M. Santos, M. S. Fonseca, A. R. Sokolonski, K. R. Deegan, R. P. Araújo et al., Propolis: types, composition, biological activities, and veterinary product patent prospecting, J Sci Food Agric

Y. L. Donadieu and . Propolis, Edition Dangles, 2008.

N. Cardinault, M. Cayeux, P. Du-sert, and P. , La propolis : origine, composition et propriétés. Phytothérapie, vol.10, pp.298-304, 2012.

J. Nicolaÿ, A. Lefief-delcourt, and R. .. Le, Les remèdes de la ruche pour votre santé. Leduc.s pratique, Le Duc S

A. J. Abbasi, F. Mohammadi, M. Bayat, S. M. Gema, H. Ghadirian et al., Applications of Propolis in Dentistry: A Review, Ethiop J Health Sci. juill, vol.28, issue.4, pp.505-517, 2018.

V. Dodwad and B. J. Kukreja, Propolis mouthwash: A new beginning, J Indian Soc Periodontol. avr, vol.15, issue.2, pp.121-126, 2011.

V. Ahuja and A. Ahuja, Apitherapy -A sweet approach to dental diseases. Part II: Propolis, J Adv Oral Res. mai, vol.2, issue.2, pp.1-8, 2011.

R. Denis, La santé par les abeilles -Bienfaits et limites de l'apithérapie, Eugen Ulmer EDS, vol.144, 2020.

V. Seidel, E. Peyfoon, D. G. Watson, and J. Fearnley, Comparative study of the antibacterial activity of propolis from different geographical and climatic zones, Phytother Res PTR. sept, vol.22, issue.9, pp.1256-63, 2008.

I. Przyby?ek and T. M. Karpi?ski, Antibacterial Properties of Propolis, Mol Basel Switz. mai, vol.24, issue.11, 2019.

A. Yildirim, G. G. Duran, N. Duran, K. Jenedi, B. S. Bolgul et al., Antiviral Activity of Hatay Propolis Against Replication of Herpes Simplex Virus Type 1 and Type 2, Med Sci Monit Int Med J Exp Clin Res. févr, vol.22, pp.422-452, 2016.

P. Schnitzler, A. Neuner, S. Nolkemper, C. Zundel, H. Nowack et al., Antiviral activity and mode of action of propolis extracts and selected compounds, Phytother Res PTR. janv, vol.24, issue.1, pp.20-28, 2010.

M. Amoros, F. Sauvager, L. Girre, and M. Cormier, In vitro antiviral activity of propolis, Apidologie, vol.23, issue.3, pp.231-240, 1992.
URL : https://hal.archives-ouvertes.fr/hal-00890989

K. Labská, H. Plodková, M. Pumannová, and K. H. Sensch, Antiviral activity of propolis special extract GH 2002 against Varicella zoster virus in vitro, Pharm. janv, vol.73, issue.12, pp.733-739, 2018.

C. Ota, C. Unterkircher, V. Fantinato, and M. T. Shimizu, Antifungal activity of propolis on different species of Candida. Mycoses, vol.44, pp.375-383, 2001.

A. Oliveira, C. S. Shinobu, R. Longhini, S. L. Franco, and T. Svidzinski, Antifungal activity of propolis extract against yeasts isolated from onychomycosis lesions, Mem Inst Oswaldo Cruz. août, vol.101, issue.5, pp.493-500, 2006.

A. Ramos and J. L. Miranda, Propolis: a review of its anti-inflammatory and healing actions, J Venom Anim Toxins Trop Dis, vol.13, issue.4, pp.697-710, 2007.

M. Wo?niak, L. Mrówczy?ska, A. Wa?kiewicz, T. Rogozi?ski, I. Ratajczak et al., The role of seasonality on the chemical composition, antioxidant activity and cytotoxicity of Polish propolis in human erythrocytes, Rev Bras Farmacogn. juin, vol.29, issue.3, pp.301-309, 2019.

B. H. Havsteen, The biochemistry and medical significance of the flavonoids, Pharmacol Ther. déc, vol.96, issue.2-3, pp.67-202, 2002.

Y. Cai, Q. Luo, M. Sun, and H. Corke, Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer, Life Sci. mars, vol.74, issue.17, pp.2157-84, 2004.

D. Sawicka, H. Car, M. H. Borawska, and J. Nikli?ski, The anticancer activity of propolis, Folia Histochem Cytobiol. avr, vol.50, issue.1, pp.25-37, 2012.

R. Czarnecki and T. Tadeusz, Effect of propolis on the healing of ethanol-and acetic acid chronic gastric ulcer in rats, ABC Ser Zool. déc, vol.52, pp.37-43, 2010.

C. Chen, C. Hsiao, S. Lee, J. Guh, P. Chiang et al., Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis, Nat Prod Res, vol.26, issue.2, pp.116-140, 2012.

P. Costa, L. B. Somensi, A. F. Da-silva-r-de-cmv-de, L. Mariano, T. Boeing et al., Role of the antioxidant properties in the gastroprotective and gastric healing activity promoted by Brazilian green propolis and the healing efficacy of Artepillin C. Inflammopharmacol, 2019.

M. Paintz and J. Metzner, On the local anaesthetic action of propolis and some of its constituents, Pharm. déc, vol.34, issue.12, pp.839-880, 1979.

A. Parolia, M. S. Thomas, M. Kundabala, and M. Mohan, Propolis and its potential uses in oral health, Int J Med Med Sci. juill, vol.2, issue.7, pp.210-215, 2010.

M. Filho, O. De-carvalho, and A. C. , Application of propolis to dental sockets and skin wounds, J Nihon Univ Sch Dent. mars, vol.32, issue.1, pp.4-13, 1990.

O. Magro-filho and A. C. De-carvalho, Topical effect of propolis in the repair of sulcoplasties by the modified Kazanjian technique. Cytological and clinical evaluation, J Nihon Univ Sch Dent. juin, vol.36, issue.2, pp.102-113, 1994.

M. F. Hayacibara, H. Koo, P. L. Rosalen, S. Duarte, E. M. Franco et al., In vitro and in vivo effects of isolated fractions of Brazilian propolis on caries development, J Ethnopharmacol, vol.101, issue.1-3, pp.110-115, 2005.

E. A. Ophori, B. N. Eriagbonye, and P. Ugbodaga, Antimicrobial activity of propolis against Streptococcus mutans, Afr J Biotechnol. sept, vol.9, issue.31, pp.4966-4975, 2010.

B. Bueno-silva, H. Koo, M. L. Falsetta, S. M. Alencar, M. Ikegaki et al., Effect of neovestitolvestitol containing Brazilian red propolis on accumulation of biofilm in vitro and development of dental caries in vivo, Biofouling, vol.29, issue.10, pp.1233-1275, 2013.

A. S. Mahmoud, K. Almas, and A. A. Dahlan, The effect of propolis on dentinal hypersensitivity and level of satisfaction among patients from a university hospital Riyadh, Saudi Arabia, Indian J Dent Res. déc, vol.10, issue.4, pp.130-137, 1999.

S. Madhavan, M. Nayak, A. Shenoy, R. Shetty, and K. Prasad, Dentinal hypersensitivity: A comparative clinical evaluation of CPP-ACP F, sodium fluoride, propolis, and placebo, J Conserv Dent JCD, vol.15, issue.4, pp.315-323, 2012.

N. A. Torwane, S. Hongal, P. Goel, B. Jain, M. Saxena et al., Effect of Two Desensitizing Agents in Reducing Dentin Hypersensitivity: An in-vivo Comparative Clinical Trial, J Clin Diagn Res JCDR. sept, vol.7, issue.9, pp.2042-2048, 2013.

L. J. Griffith, M. Davies, and N. X. West, Hypersensibilité dentinaire

, Information Dentaire

N. Samet, C. Laurent, S. M. Susarla, and N. Samet-rubinsteen, The effect of bee propolis on recurrent aphthous stomatitis: a pilot study, Clin Oral Investig. juin, vol.11, issue.2, pp.143-150, 2007.

, Stomatite aphteuse récidivante -Troubles dentaires

, Édition professionnelle du Manuel MSD

L. Awawdeh, A. Jamleh, A. Beitawi, and M. , The Antifungal Effect of Propolis Endodontic Irrigant with Three Other Irrigation Solutions in Presence and Absence of Smear Layer: An In Vitro Study, Iran Endod J. avr, vol.13, issue.2, pp.234-243, 2018.

H. Al-qathami, A. , and E. , Comparison of sodium hypochlorite, propolis and saline as root canal irrigants: A pilot study, Saudi Dent J. août, vol.15, pp.100-102, 2003.

L. Awawdeh, M. Al-beitawi, and H. M. , Effectiveness of propolis and calcium hydroxide as a short-term intracanal medicament against Enterococcus faecalis: a laboratory study, Aust Endod J J Aust Soc Endodontology Inc. août, vol.35, issue.2, pp.52-60, 2009.

O. Oncag, D. Cogulu, A. Uzel, and K. Sorkun, Efficacy of propolis as an intracanal medicament against Enterococcus faecalis. Gen Dent, vol.54, pp.319-341, 2006.

F. Özan, Z. Sümer, Z. A. Polat, K. Er, Ü. Özan et al., Effect of Mouthrinse Containing Propolis on Oral Microorganisms and Human Gingival Fibroblasts, Eur J Dent, vol.1, issue.4, pp.195-201, 2007.

H. Koo, J. A. Cury, P. L. Rosalen, G. Ambrosano, M. Ikegaki et al., Effect of a mouthrinse containing selected propolis on 3-day dental plaque accumulation and polysaccharide formation, Caries Res. déc, vol.36, issue.6, pp.445-453, 2002.

M. P. Martin and R. Pileggi, A quantitative analysis of Propolis: a promising new storage media following avulsion, Dent Traumatol Off Publ Int Assoc Dent Traumatol. avr, vol.20, issue.2, pp.85-94, 2004.

E. Gebaraa, A. N. Pustiglioni, L. De-lima, and M. Mayer, Propolis extract as an adjuvant to periodontal treatment, Oral Health Prev Dent. janv, vol.1, issue.1, pp.29-35, 2003.

R. Cairo, R. T. Gomes, M. W. Santos, R. Lemos, S. Abreu et al., Periodontitis treatment with Brazilian green propolis gel, Pharmacologyonline. janv, vol.3, pp.336-377, 2006.

N. Bhat, S. Bapat, K. Asawa, M. Tak, P. Chaturvedi et al., The antiplaque efficacy of propolis-based herbal toothpaste: A crossover clinical study, J Nat Sci Biol Med. déc, vol.6, issue.2, pp.364-372, 2015.

M. Sato, S. Fujiwara, M. Nagayama, R. Yamaguchi, C. Tokuda et al., Effect of propolis and propolis-containing toothpaste on the formation of dental plaque in vitro, ORAL Ther Pharmacol. avr, vol.20, issue.1, pp.5-10, 2001.

R. Vanni, N. M. Waldner-tomic, G. N. Belibasakis, T. Attin, P. R. Schmidlin et al., Antibacterial Efficacy of a Propolis Toothpaste and Mouthrinse Against a Supragingival Multispecies Biofilm, Oral Health Prev Dent. juin, vol.13, issue.6, pp.531-536, 2015.

N. Malhotra, S. P. Rao, S. Acharya, and B. Vasudev, Comparative in vitro evaluation of efficacy of mouthrinses against Streptococcus mutans, Lactobacilli and Candida albicans, Oral Health Prev Dent. janv, vol.9, issue.3, pp.261-269, 2011.

A. E. Akca, G. Akca, F. T. Topçu, E. Macit, L. Pikdöken et al., The Comparative Evaluation of the Antimicrobial Effect of Propolis with Chlorhexidine against Oral Pathogens: An In Vitro Study, BioMed Res Int. févr, p.3627463, 2016.

M. L. Martins, A. Monteiro, J. Guimarães, C. T. Guimarães-mb-de, R. F. Da-silva et al., Cytotoxic and antibacterial effect of a red propolis mouthwash, with or without fluoride, on the growth of a cariogenic biofilm, Arch Oral Biol. juill, vol.107, p.104512, 2019.

M. P. De-luca, J. R. Franca, F. Macedo, L. Grenho, M. E. Cortes et al., Propolis varnish: antimicrobial properties against cariogenic bacteria, cytotoxicity, and sustainedrelease profile, BioMed Res Int. mai, p.348647, 2014.

M. O. Wassel and M. A. Khattab, Antibacterial activity against Streptococcus mutans and inhibition of bacterial induced enamel demineralization of propolis, miswak, and chitosan nanoparticles based dental varnishes, J Adv Res. juill, vol.8, issue.4, pp.387-92, 2017.

A. P. Iswari, E. Riyanti, and D. Hadidjah, Plaque index differences before and after teeth brushing with and without propolis dentifrice, Padjadjaran J Dent, vol.22, issue.1

M. Tanasiewicz, M. Skucha-nowak, M. Dawiec, W. Król, D. Skaba et al., Influence of hygienic preparations with a 3% content of ethanol extract of Brazilian propolis on the state of the oral cavity, Adv Clin Exp Med Off Organ Wroclaw Med Univ. févr, vol.21, issue.1, pp.81-92, 2012.

N. A. Listyasari and O. Santoso, Inhibition of dental plaque formation by toothpaste containing propolis, Dent J Maj Kedokt Gigi. déc, vol.45, issue.4, pp.208-219, 2012.

D. Skaba, T. Morawiec, M. Tanasiewicz, A. Mertas, E. Bobela et al., Influence of the toothpaste with brazilian ethanol extract propolis on the oral cavity health. Evid-Based, Complement Altern Med ECAM. juin, vol.2013, pp.215391-215391, 2013.

S. Mohsin, B. Manohar, S. Rajesh, and Y. Asif, The effects of a dentifrice containing propolis on Mutans Streptococci: a clinico-microbiological study, Ethiop J Health Sci. janv, vol.25, issue.1, pp.9-16, 2015.

S. Peycheva, E. Apostolova, P. Gardjeva, Z. Peychev, V. Kokova et al., Effect of Bulgarian propolis on the oral microflora in adolescents with plaque-induced gingivitis, 2018.

C. Duailibe-sa-de, A. G. Gonçalves, and F. Ahid, Effect of a propolis extract on streptococcus mutans counts in vivo, J Appl Oral Sci, vol.15, issue.5, pp.420-423, 2007.

E. Pereira, J. Da-silva, F. F. Silva, D. Luca, M. P. Ferreira et al., Clinical Evidence of the Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: A Phase II Study, Evid-Based Complement Altern Med ECAM, p.750249, 2011.

K. S. Hegde, S. S. Bhat, A. Rao, and S. Sain, Effect of Propolis on Streptococcus mutans Counts: An in vivo Study, Int J Clin Pediatr Dent. janv, vol.6, issue.1, pp.22-27, 2013.

E. Neto, L. Valadas, P. Lobo, A. Fernandes, C. Da et al., Dose-response evaluation of propolis dental varnish in children: A randomized study, Recent Pat Biotechnol. août, vol.14, issue.1, pp.41-48, 2019.

N. Suriamah, R. Lessang, and Y. Kemal, Effectiveness of toothpaste containing propolis, tea tree oil, and sodium monofluorophosphate against plaque and gingivitis, Int J Appl Pharm. avr, vol.11, pp.114-120, 2019.

T. Piekarz, A. Mertas, K. Wiatrak, R. Rój, P. Kownacki et al., The Influence of Toothpaste Containing Australian Melaleuca alternifolia Oil and Ethanolic Extract of Polish Propolis on Oral Hygiene and Microbiome in Patients Requiring Conservative Procedures. Mol Basel Switz, vol.22, 2017.

L. Lisa, E. Carac, G. Barbu, V. Robu, and S. , The synergistic antioxidant effect and antimicrobial efficacity of propolis, myrrh and chlorhexidine as beneficial toothpaste components, Rev Chim -Buchar -Orig Ed. sept, vol.68, issue.9, pp.2060-2065, 2017.

M. P. De-luca, I. A. Freires, A. Gala-garcía, V. R. Santos, M. P. Vale et al., The anticaries activity and toxicity of an experimental propolis-containing varnish, Braz Oral Res. juin, vol.31, p.45, 2017.

J. R. Franca, D. Luca, M. P. Ribeiro, T. G. Castilho, R. O. Moreira et al., Propolisbased chitosan varnish: drug delivery, controlled release and antimicrobial activity against oral pathogen bacteria, BMC Complement Altern Med. déc, vol.14, issue.1, p.478, 2014.

M. O. Wassel and D. I. Sherief, Ion release and enamel remineralizing potential of miswak, propolis and chitosan nano-particles based dental varnishes, Pediatr Dent J. avr, vol.29, issue.1, pp.1-10, 2019.

L. Vu, . Président, and . Jury, Signature : Vu, la Directrice de l'UFR des Sciences Odontologiques