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, Les néoplasies sont la troisième cause de mortalité dans la population des transplantés rénaux et l'immunosuppression est reconnue comme facteur favorisant. L'objectif de cette étude a été d'évaluer l'incidence et la morbi-mortalité des carcinomes urothéliaux dans cette population
, Sur 31543 transplantés rénaux, 103 patients ont eu une tumeur des voies excrétrices urinaires. Nous avons recueillis les données clinico-biologique de la tumeur au diagnostic initial, les modalités des traitements, les données de l'immunosuppression et du devenir oncologique des patients. L'objectif principal a été la mesure de l, 1997.
, Résultats : Ont été inclus 50 tumeurs de vessie non infiltrantes, 37 infiltrantes, 8 tumeurs des voies excrétrices supérieures natives et 8 du transplant. L'incidence des tumeurs toutes localisations confondues était de 327 pour 100 000 sur 21 ans soit 15,6 pour 100 000 par an, L'objectif secondaire a été l'étude de la survie des patients et du devenir des transplants, vol.39, p.58
, mois, la survie globale pour l'ensemble de la population était de 80,7%, 72,3%, et 70,7% à 12, 24 et 36 mois respectivement. A la fin du suivi 72% des transplants étaient fonctionnels, 26% des patients sont retournés en dialyse dont 18% transplantectomisés
, L'incidence annuelle des tumeurs urothéliales est similaire aux données de la population générale. Cependant elles sont plus agressives chez les transplantés rénaux. La gestion de l'immunosuppression reste un problème difficile
, Mots clés : Transplantation rénale, carcinome urothélial, tumeur de vessie, tumeur des voies excrétrices supérieures