, 39 patients ont eu une BP et une AUC à M12. Tous les patients étaient traités par tacrolimus
, Le délai moyen entre la transplantation et la réalisation de l'AUC était de 376±28 jours
8±15,2 h.mg/L. 28 % de patients avaient une AUC < 30 h.mg/L (Figure 2), 61,8 % une AUC entre 30 et 60 h.mg/L et 10,2 % avaient une AUC > 60 h.mg/L. Selon le site ABIS, la moitié des patients avaient une posologie adéquate de MMF pour un objectif, p.45 ,
Les 2 patients ont été traités par Solumedrol® 500 mg/j pendant 3 jours. Un patient avait une AUC > 30 h.mg/L et un, une AUC < 30 h ,
, Les 5 patients avaient une AUC > 30 h.mg/L. Ils n, -Cinq lésions borderline (quatre rejets : i1t2 et un rejet : i0t1)
, Deux BP montraient un marquage isolé du C4d au niveau des capillaires péritubulaires (dont une greffe ABO-incompatible). L'AUC était > 30 h.mg/L chez ces 2 patients
, Des lésions de FIAT étaient retrouvées chez 63 % des patients, dont l'AUC était < 30 h.mg/L et
AUC était > 30 h.mg/L. Il y avait 64% d'inflammation dans les zones de fibrose dans le groupe AUC < 30 h.mg/L , contre 59% dans le groupe AUC > 30 h ,
, Des lésions vasculaires chroniques étaient retrouvées dans 70% des cas dans les 2 groupes
, Enfin, 4 (11%) BP (chez des patients dont la néphropathie initiale était indéterminée) montraient
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