Skip to Main content Skip to Navigation
Master Thesis

La maladie de Parkinson : état de l’art et perspectives. L’apport de l’imagerie moléculaire dans la recherche de l’amélioration de la thérapie

Abstract : Parkinson disease was first described in 1817 by James Parkinson. More than 200 years of research demonstrates that it is a neurodegenerative pathology, characterized by dopaminergic cells death associated with protein α-synuclein aggregates under Lewy’s bodies form. One of the most affected brain areas, called substancia nigra pars compacta, is also responsible of “symptomatic triad” which is particularly handicapping gathering akinesia, rigidity and shaking. Age, α-synuclein gene mutation and environmental exposition such as pesticides are known to be risk factors. MALDI-TOF applied to research on Parkinson’s disease draw perspectives for specifics biomarkers research which is an important key in a context where there is no diagnosis of certainty. We also discuss the perspectives about improving treatments which are only symptomatic, since the etiology of this pathology have not been underlined. The discussion of MALDI-TOF applied to Deep Brain Stimulation (DBS) is aborded through parameters improvements to optimize this technic in order to lessened induced side effects. Biomarkers research possibilities are also discussed through spectral image acquisition by MALDI-TOF and their comparative analysis.
Document type :
Master Thesis
Complete list of metadatas

Cited literature [174 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-02887923
Contributor : Frédérique Gambade <>
Submitted on : Thursday, July 2, 2020 - 3:48:53 PM
Last modification on : Tuesday, July 14, 2020 - 3:11:27 AM
Long-term archiving on: : Thursday, September 24, 2020 - 5:18:30 AM

File

Pharmacie_2020_Simonetti.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-02887923, version 1

Collections

Citation

Pierre Simonetti. La maladie de Parkinson : état de l’art et perspectives. L’apport de l’imagerie moléculaire dans la recherche de l’amélioration de la thérapie. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02887923⟩

Share

Metrics

Record views

38

Files downloads

19