K. Rojas and A. Stuckey, Breast cancer epidemiology and risk factors, Clinical obstetrics and gynecology, vol.59, issue.4, pp.651-672, 2016.

G. Defossez, S. Le-guyader-peyrou, Z. Uhry, P. Grosclaude, M. Colonna et al., Estimations nationales de l'incidence et de la mortalité par cancer en France métropolitaine entre, 1990.

P. M. Webb, M. C. Cummings, C. J. Bain, and C. M. Furnival, Changes in survival after breast cancer: improvements in diagnosis or treatment? The Breast, vol.13, pp.7-14, 2004.

D. A. Berry, K. A. Cronin, and S. K. Plevritis, Effect of Screening and Adjuvant Therapy on Mortality from Breast Cancer, N Engl J Med, vol.353, issue.17, pp.1784-1792, 2005.

A. Cowppli-bony, Z. Uhry, and L. Remontet, Survival of solid cancer patients in France, 1989-2013: a population-based study, Eur J Cancer Prev, vol.26, issue.6, pp.461-468, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01540069

T. Renaud, L. Rioux, and . France, , p.272, 2018.

D. Béland and J. P. Viriot-durandal, Aging in france: population trends, policy issues, and research institutions, The Gerontologist, vol.53, issue.2, pp.191-197, 2013.

L. Biganzoli, H. Wildiers, and C. Oakman, Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA), Lancet Oncol, vol.13, issue.4, pp.148-160, 2012.

A. G. Pallis, C. Fortpied, and U. Wedding, EORTC elderly task force position paper: approach to the older cancer patient, Eur J Cancer, vol.46, issue.9, pp.1502-1513, 2010.

N. Pondé, L. Dal-lago, and A. Ha, Adjuvant chemotherapy in elderly patients with breast cancer: key challenges, Expert Rev Anticancer Ther, vol.16, issue.6, pp.661-671, 2016.

A. M. Bouvier, B. Trétarre, P. Delafosse, P. Grosclaude, and K. Jéhannin-ligier, , 2018.

, Les cancers en France en 2018. L'essentiel des faits et des chiffres, 2019.

J. Y. Pierga, V. Girre, and V. Laurence, Characteristics and outcome of 1755 operable breast cancers in women over 70 years of age, Breast, vol.13, issue.5, pp.369-375, 2004.

S. O. Ogunbiyi, S. Lee, J. Mathew, and K. L. Cheung, Primary breast cancer in the elderly: a systematic literature review on histological type and clinical outcome, Future Oncol

D. Xianglin, J. L. Freeman, A. B. Nattinger, and J. S. Goodwin, Survival of women after breast conserving surgery for early stage breast cancer, Breast Cancer Res Treat, vol.72, issue.1, pp.23-31, 2002.

C. Bouchardy, E. Rapiti, and G. Fioretta, Undertreatment strongly decreases prognosis of breast cancer in elderly women, J Clin Oncol, vol.21, pp.3580-3587, 2003.

R. A. Freedman, Y. He, E. P. Winer, and N. L. Keating, Trends in Racial and Age Disparities in Definitive Local Therapy of Early-Stage Breast Cancer, JCO, vol.27, issue.5, pp.713-719, 2009.

D. Martinez-ramos, L. Simon-monterde, R. Queralt-martin, C. Suelves-piqueres, P. Menor-duran et al., Breast cancer in octogenarian. Are we doing our best? A population-registry based study, Breast, vol.38, pp.81-85, 2018.

, Sixièmes recommandations pour la pratique clinique de la prise en charge des cancers du sein de Nice

G. Curigliano, H. J. Burstein, and E. P. Winer, De-escalating and escalating treatments for early-stage breast cancer: the St, Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer, vol.29, p.2153, 2009.

, Ann Oncol, vol.28, issue.8, pp.1700-1712, 2017.

M. Meresse, A. D. Bouhnik, and M. K. Bendiane, Chemotherapy in Old Women with Breast Cancer: Is Age Still a Predictor for Under Treatment?, Breast J, vol.23, issue.3, pp.256-266, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-01994790

T. Lemasters, S. S. Madhavan, U. Sambamoorthi, H. W. Hazard-jenkins, K. M. Kelly et al., Receipt of Guideline-Concordant Care Among Older Women With Stage I-III Breast Cancer: A Population-Based Study, J Natl Compr Canc Netw, vol.16, issue.6, pp.703-710, 2018.

V. C. Hamelinck, A. M. Stiggelbout, C. Van-de-velde, G. J. Liefers, and E. Bastiaannet, Treatment recommendations for older women with breast cancer: A survey among surgical, radiation and medical oncologists, Eur J Surg Oncol, vol.43, issue.7, pp.1288-1296, 2017.

J. Mandelblatt, B. Kreling, M. Figeuriedo, and S. Feng, What Is the Impact of Shared Decision Making on Treatment and Outcomes for Older Women With Breast Cancer?, JCO, vol.24, issue.30, pp.4908-4913, 2006.

S. H. Javid, J. M. Unger, J. R. Gralow, C. M. Moinpour, A. J. Wozniak et al., A prospective analysis of the influence of older age on physician and patient decision-making when considering enrollment in breast cancer clinical trials (SWOG S0316), The oncologist, vol.17, issue.9, pp.1180-1190, 2012.

J. Sun and S. Chia, Adjuvant chemotherapy and HER-2-directed therapy for early-stage breast cancer in the elderly, Br J Cancer, 2017.

H. B. Muss, S. Woolf, and D. Berry, Adjuvant Chemotherapy in Older and Younger Women With Lymph Node Positive Breast Cancer, p.9, 2005.

Y. W. Jeon, S. H. You, and J. E. Lee, Optimal treatment of breast cancer in women older than 75 years: a Korea Breast Cancer Registry analysis, Breast Cancer Res Treat, vol.178, issue.3, pp.693-701, 2019.

S. E. Ward, G. R. Holmes, and A. Ring, Adjuvant Chemotherapy for Breast Cancer in Older Women: An Analysis of Retrospective English Cancer Registration Data, Clin Oncol (R Coll Radiol), vol.31, issue.7, pp.444-452, 2019.

T. Blackmore, R. Lawrenson, and C. Lao, The characteristics, management and outcomes of older women with breast cancer in New Zealand, Maturitas, vol.112, pp.64-70, 2018.

C. W. Wallwiener, A. D. Hartkopf, and E. Grabe, Adjuvant chemotherapy in elderly patients with primary breast cancer: are women ?65 undertreated?, J Cancer Res Clin Oncol, vol.142, issue.8, pp.1847-1853, 2016.

L. Hch, W. Y. Chen, and W. N. Huang, Impact of Adjuvant Chemotherapy in Elderly Breast Patients in Taiwan, A Hospital-Based Study, Asian Pac J Cancer Prev, vol.17, issue.10, pp.4591-4597, 2016.

M. Schneider, I. H. Zuckerman, and E. Onukwugha, Chemotherapy treatment and survival in older women with estrogen receptor-negative metastatic breast cancer: a population-based analysis, J Am Geriatr Soc, vol.59, issue.4, pp.637-646, 2011.

D. Crivellari, M. Bonetti, and M. Castiglione-gertsch, Burdens and Benefits of Adjuvant Cyclophosphamide, Methotrexate, and Fluorouracil and Tamoxifen for Elderly Patients With Breast Cancer: The International Breast Cancer Study Group Trial VII, JCO, vol.18, issue.7, pp.1412-1422, 2000.

N. K. Ibrahim, A. U. Buzdar, L. Asmar, R. L. Theriault, and G. N. Hortobagyi, Doxorubicin-based adjuvant chemotherapy in elderly breast cancer patients: The M.D. Anderson experience, with long-term followup, Annals of Oncology, vol.11, issue.12, pp.1597-1601, 2000.

S. H. Javid, J. M. Unger, J. R. Gralow, C. M. Moinpour, A. J. Wozniak et al., A prospective analysis of the influence of older age on physician and patient decision-making when considering enrollment in breast cancer clinical trials (SWOG S0316), The oncologist, vol.17, issue.9, pp.1180-1190, 2012.

R. A. Freedman, I. Vaz-luis, W. T. Barry, H. Lii, N. U. Lin et al., Patterns of chemotherapy, toxicity, and short-term outcomes for older women receiving adjuvant trastuzumab-based therapy, Breast cancer research and treatment, vol.145, issue.2, pp.491-501, 2014.

F. Perrone, F. Nuzzo, D. Rella, and F. , Weekly docetaxel versus CMF as adjuvant chemotherapy for older women with early breast cancer: final results of the randomized phase III ELDA trial, Annals of Oncology, vol.26, issue.4, pp.675-682, 2015.

R. A. Freedman, D. K. Seisler, J. C. Foster, J. A. Sloan, J. M. Lafky et al., Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511), Breast cancer research and treatment, vol.161, issue.2, pp.363-373, 2017.

S. Li, J. Liu, B. A. Virnig, and A. J. Collins, Association between adjuvant chemotherapy and risk of acute kidney injury in elderly women diagnosed with early-stage breast cancer, Breast cancer research and treatment, vol.161, issue.3, pp.515-524, 2017.

M. Barginear, A. C. Dueck, J. B. Allred, C. Bunnell, H. J. Cohen et al., Age and the Risk of Paclitaxel-Induced Neuropathy in Women with Early-Stage Breast Cancer (Alliance A151411): Results from 1,881 Patients from Cancer and Leukemia Group B (CALGB) 40101. The oncologist, vol.24, pp.617-623, 2019.

J. O. Hopkins, J. Allred, A. Hurria, A. Jatoi, J. M. Lafky et al., , 2017.

. Lymphedema, musculoskeletal events and arm function in older patients receiving adjuvant chemotherapy for breast cancer (Alliance A171302), Breast cancer research and treatment, vol.166, issue.3, pp.793-808

X. L. Du, R. Xia, and C. Liu, Cardiac toxicity associated with anthracycline-containing chemotherapy in older women with breast cancer, Cancer, vol.115, issue.22, pp.5296-5308, 2009.

K. A. Cadoo, P. G. Morris, E. P. Cowell, S. Patil, C. A. Hudis et al., Adjuvant chemotherapy and trastuzumab is safe and effective in older women with small, node-negative, HER2-positive early-stage breast cancer, Clinical breast cancer, vol.16, issue.6, pp.487-493, 2016.

J. Chen, J. B. Long, A. Hurria, C. Owusu, R. M. Steingart et al., Incidence of heart failure or cardiomyopathy after adjuvant trastuzumab therapy for breast cancer, Journal of the American College of Cardiology, vol.60, issue.24, pp.2504-2512, 2012.

E. J. Bowles, R. Wellman, H. S. Feigelson, A. A. Onitilo, A. N. Freedman et al., Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study, Journal of the National Cancer Institute, vol.104, issue.17, pp.1293-1305, 2012.

B. T. Chen, T. Jin, S. K. Patel, N. Ye, H. Ma et al., Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study, Breast cancer research and treatment, vol.176, issue.1, pp.181-189, 2019.

M. Lange, N. Heutte, S. Noal, O. Rigal, J. E. Kurtz et al., Cognitive Changes After Adjuvant Treatment in Older Adults with Early-Stage Breast Cancer, The oncologist, vol.24, issue.1, pp.62-68, 2019.
URL : https://hal.archives-ouvertes.fr/inserm-02097848

A. Hurria, E. Soto-perez-de-celis, J. B. Allred, H. J. Cohen, A. Arsenyan et al., Functional decline and resilience in older women receiving adjuvant chemotherapy for breast cancer, Journal of the American Geriatrics Society, vol.67, issue.5, pp.920-927, 2019.

B. T. Chen, T. Jin, S. K. Patel, N. Ye, C. L. Sun et al., Gray matter density reduction associated with adjuvant chemotherapy in older women with breast cancer, Breast cancer research and treatment, vol.172, issue.2, pp.363-370, 2018.

C. Quinten, C. Kenis, M. Hamaker, A. Coolbrandt, B. Brouwers et al.,

A. Smeets, The effect of adjuvant chemotherapy on symptom burden and quality of life over time; a preliminary prospective observational study using individual data of patients aged? 70 with early stage invasive breast cancer, Journal of geriatric oncology, vol.9, issue.2, pp.152-162, 2018.

A. Vincent-salomon, G. Macgrogan, J. Couturier, L. Arnould, and S. Mathoulin-pélissier, Re: HER2 testing in the real world, Journal of the National Cancer Institute, vol.95, issue.8, pp.628-628, 2003.

. Penault-llorca, « [Immunochemistry evaluation of HER2 status in infiltration breast cancer

A. De-nonneville, C. Jauffret, and A. Gonçalves, Breast Cancer Res Treat, vol.175, p.379, 2019.

P. R. Rosenbaum, Model-based direct adjustment, J Am Stat Assoc, vol.82, pp.387-394, 1987.

A. De-nonneville, Adjuvant chemotherapy in pT1ab node-negative triple-negative breast carcinomas: Results of a national multi-institutional retrospective study, Eur. J. Cancer, vol.84, pp.34-43, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02282824

V. Elm, E. Altman, D. G. Egger, M. Pocock, S. J. Gøtzsche et al., , 2007.

, The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies, Annals of internal medicine, vol.147, issue.8, pp.573-577

R. Gennari, G. Curigliano, and N. Rotmensz, Breast carcinoma in elderly women: features of disease presentation, choice of local and systemic treatments compared with younger postmenopasual patients, Cancer, vol.101, issue.6, pp.1302-1310, 2004.

S. H. Giordano, Z. Duan, Y. Kuo, G. N. Hortobagyi, and J. S. Goodwin, Use and outcomes of adjuvant chemotherapy in older women with breast cancer, J Clin Oncol, vol.24, issue.18, pp.2750-2756, 2006.

E. B. Elkin, A. Hurria, N. Mitra, D. Schrag, and K. S. Panageas, Adjuvant Chemotherapy and Survival in Older Women With Hormone Receptor-Negative Breast Cancer: Assessing Outcome in a Population-Based, Observational Cohort. JCO, vol.24, issue.18, pp.2757-2764, 2006.

J. Pierga, V. Girre, and V. Laurence, Characteristics and outcome of 1755 operable breast cancers in women over 70 years of age, The Breast, vol.13, issue.5, pp.369-375, 2004.

L. Rossi, D. Stevens, and J. Pierga, Adjuvant Chemotherapy on Breast Cancer Survival: A Real-World Population. Bathen TF, vol.10, issue.7, p.132853, 2015.

C. A. Bellera, M. Rainfray, and S. Mathoulin-pélissier, Screening older cancer patients: first evaluation of the G-8 geriatric screening tool, Annals of Oncology, vol.23, issue.8, pp.2166-2172, 2012.

K. S. Albain, W. E. Barlow, and S. Shak, Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial, The Lancet Oncology, vol.11, issue.1, p.55, 2010.