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Master Thesis

Infections néonatales bactériennes précoces chez les nouveau-nés prématurés de moins de 32 semaines aménorrhée : la procalcitonine, un outil indispensable

Abstract : Background: Procalcitonin (PCT), specific biomarker of early-onset neonatal sepsis (EOS), is rarely studied in premature infants born under 32 weeks.
Objectives: Determine the threshold of cord blood PCT and the interest of PCT during the first sixth hours of life in preterm newborns under 32 weeks.
Study design: This multicenter retrospective study includes all preterm newborns under 32 weeks, born between May 2016 and April 2018 in the University Hospital of Nice and Paris Sud (Bicêtre), who had PCT measurement and presented infection risk factor(s).
Results: Among 260 included neonates, 26 were infected. The threshold of PCT was 0,98 ng/ml (sensitivity 0,65, specificity 0,90, positive predictive value 0,42 and negative predictive value 0,96). The threshold of cord blood PCT was 1 ng/ml (sensitivity 0,63, specificity 0,89, positive predictive value 0,42 and negative predictive value 0,95). The threshold of PCT during the first hours of life was 0,98 ng/ml (sensitivity 0,86, specificity 0,93, positive predictive value 0,5 and negative predictive value 0,99). The median of samples was 60 minutes (20-219). The area under receiver operating characteristics (ROC) curve of PCT collected during the first hours of life was significatively higher than the cord blood PCT (0,94 vs 0,75; p=0,03).
Conclusion: The threshold of PCT was higher than on full-term newborns and had a good specificity. PCT collected during the four first hours of life was sensitive and specific in the case of an EOS diagnosis.
Document type :
Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02936442
Contributor : Bibliothèque Universitaire de Médecine Nice Connect in order to contact the contributor
Submitted on : Friday, September 11, 2020 - 12:00:16 PM
Last modification on : Sunday, January 17, 2021 - 3:09:35 AM

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Blandine Bianco. Infections néonatales bactériennes précoces chez les nouveau-nés prématurés de moins de 32 semaines aménorrhée : la procalcitonine, un outil indispensable. Médecine humaine et pathologie. 2019. ⟨dumas-02936442⟩

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