. .. Psychothérapie-familiale,

, Méta-analyses sur l'efficacité des traitements dans les états mentaux à risque

. .. Sur-le-fonctionnement, , p.61

. .. Discussion,

. .. Conclusion,

. .. Bibliographie,

. .. Serment-d'hippocrate,

M. Penttilä, E. Jääskeläinen, N. Hirvonen, M. Isohanni, and J. Miettunen, Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis, Br. J. Psychiatry, vol.205, pp.88-94, 2014.

A. R. Yung and P. D. Mcgorry, The Prodromal Phase of First-episode Psychosis: Past and Current Conceptualizations, Schizophr. Bull, vol.22, pp.353-70, 1996.

A. R. Yung, P. D. Mcgorry, C. A. Mcfarlane, H. J. Jackson, G. C. Patton et al., Monitoring and care of young people at incipient risk of psychosis, Schizophr. Bull, vol.22, pp.283-303, 1996.

F. Schultze-lutter, Subjective Symptoms of Schizophrenia in Research and the Clinic: The Basic Symptom Concept, Schizophr. Bull, vol.35, pp.5-8, 2009.

P. Fusar-poli, I. Bonoldi, A. R. Yung, S. Borgwardt, M. J. Kempton et al., Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk, Arch. Gen. Psychiatry, vol.69, pp.220-229, 2012.

P. Fusar-poli, M. Cappucciati, S. Borgwardt, S. W. Woods, J. Addington et al., Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk: A Meta-analytical Stratification, JAMA Psychiatry, vol.73, pp.113-133, 2016.

P. Fusar-poli, A. Bechdolf, M. J. Taylor, I. Bonoldi, W. T. Carpenter et al., At Risk for Schizophrenic or Affective Psychoses? A Meta-Analysis of DSM/ICD Diagnostic Outcomes in Individuals at High Clinical Risk, Schizophr. Bull, vol.39, pp.923-955, 2013.

C. Michel, S. Ruhrmann, B. G. Schimmelmann, J. Klosterkötter, and F. Schultze-lutter, Course of clinical high-risk states for psychosis beyond conversion, Eur. Arch. Psychiatry Clin. Neurosci, vol.268, pp.39-48, 2018.

S. De-wit, P. F. Schothorst, B. Oranje, T. B. Ziermans, S. Durston et al., Adolescents at ultra-high risk for psychosis: long-term outcome of individuals who recover from their at-risk state, Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol, vol.24, pp.865-73, 2014.

P. D. Mcgorry, A. R. Yung, L. J. Phillips, H. P. Yuen, S. Francey et al., Randomized Controlled Trial of Interventions Designed to Reduce the Risk of Progression to First-Episode Psychosis in a Clinical Sample With Subthreshold Symptoms, Arch. Gen. Psychiatry, vol.59, pp.921-929, 2002.

L. Phillips, P. Mcgorry, H. Yuen, J. Ward, K. Donovan et al., Medium term follow-up of a randomized controlled trial of interventions for young people at ultra high risk of psychosis, Schizophr. Res, vol.96, pp.25-33, 2007.

T. H. Mcglashan, R. B. Zipursky, D. Perkins, J. Addington, T. Miller et al., Double-Blind Trial of Olanzapine Versus Placebo in Patients Prodromally Symptomatic for Psychosis, Am. J. Psychiatry, vol.163, pp.790-799, 2006.

S. Ruhrmann, A. Bechdolf, K. Kühn, M. Wagner, F. Schultze-lutter et al., Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis, Br. J. Psychiatry. Suppl, vol.51, pp.88-95, 2007.

H. Häfner, K. Maurer, S. Ruhrmann, A. Bechdolf, J. Klosterkötter et al., Early detection and secondary prevention of psychosis: facts and visions, Eur. Arch. Psychiatry Clin. Neurosci, vol.254, pp.117-145, 2004.

S. W. Woods, E. M. Tully, B. C. Walsh, K. A. Hawkins, J. L. Callahan et al., Aripiprazole in the treatment of the psychosis prodrome, Br. J. Psychiatry, vol.191, pp.96-101, 2007.

G. Berger, M. Dell'olio, P. Amminger, B. Cornblatt, L. Phillips et al., Neuroprotection in emerging psychotic disorders, Early Interv. Psychiatry, vol.1, pp.114-141, 2007.

P. Fusar-poli, L. Valmaggia, and P. Mcguire, Can antidepressants prevent psychosis?, The Lancet, vol.370, pp.1746-1754, 2007.

B. A. Cornblatt, T. Lencz, C. W. Smith, R. Olsen, A. M. Auther et al., Can antidepressants be used to treat the schizophrenia prodrome? Results of a prospective, naturalistic treatment study of adolescents, J. Clin. Psychiatry, vol.68, pp.546-57, 2007.

E. F. Walker, B. A. Cornblatt, J. Addington, K. S. Cadenhead, T. D. Cannon et al., The relation of antipsychotic and antidepressant medication with baseline symptoms and symptom progression: A naturalistic study of the North American Prodrome Longitudinal Sample, Schizophr. Res, vol.115, pp.50-57, 2009.

P. Fusar-poli, M. Frascarelli, L. Valmaggia, M. Byrne, D. Stahl et al., Antidepressant, antipsychotic and psychological interventions in subjects at high clinical risk for psychosis: OASIS 6-year naturalistic study, Psychol. Med, vol.45, pp.1327-1366, 2015.

M. Schlögelhofer, G. P. Amminger, M. R. Schaefer, P. Fusar-poli, S. Smesny et al., Polyunsaturated fatty acids in emerging psychosis: a safer alternative, Early Interv. Psychiatry, vol.8, pp.199-208, 2014.

G. P. Amminger, M. R. Schäfer, K. Papageorgiou, C. M. Klier, S. M. Cotton et al., Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebocontrolled trial, Arch. Gen. Psychiatry, vol.67, pp.146-54, 2010.

W. S. Fenton, J. Hibbeln, and M. Knable, Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia, Biol. Psychiatry, vol.47, pp.8-21, 2000.

G. P. Amminger, M. R. Schäfer, M. Schlögelhofer, C. M. Klier, and P. D. Mcgorry, Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study, Nat. Commun, vol.6, p.7934, 2015.

G. P. Amminger, A. Mechelli, S. Rice, S. Kim, C. M. Klier et al., Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids, Transl. Psychiatry, vol.5, p.495, 2015.

P. D. Mcgorry, B. Nelson, C. Markulev, H. P. Yuen, M. R. Schäfer et al.,

, Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders: The NEURAPRO Randomized Clinical Trial, JAMA Psychiatry, vol.74, pp.19-27, 2017.

K. Cadenhead, J. Addington, T. Cannon, B. Cornblatt, D. Mathalon et al., Omega-3 Fatty Acid Versus Placebo in a Clinical High-Risk Sample From the North American Prodrome Longitudinal Studies (NAPLS) Consortium, Schizophr. Bull, vol.43, p.16, 2017.

G. E. Berger, S. J. Wood, M. Ross, C. A. Hamer, R. M. Wellard et al., Neuroprotective effects of lowdose lithium in individuals at ultra-high risk for psychosis. A longitudinal MRI/MRS study, Curr. Pharm. Des, vol.18, pp.570-575, 2012.

H. K. Manji, G. J. Moore, and G. Chen, Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?, Biol. Psychiatry, vol.46, pp.929-969, 1999.

S. Stahl, Stahl's essential psychopharmacology neuroscientific basis and practical applications

S. W. Woods, B. C. Walsh, K. A. Hawkins, T. J. Miller, J. R. Saksa et al., Glycine treatment of the risk syndrome for psychosis: Report of two pilot studies, Eur. Neuropsychopharmacol, vol.23, pp.931-971, 2013.

J. T. Kantrowitz, S. W. Woods, E. Petkova, B. Cornblatt, C. M. Corcoran et al., D-serine for the treatment of negative symptoms in individuals at clinical high risk of schizophrenia: a pilot, double-blind, placebo-controlled, randomised parallel group mechanistic proof-of-concept trial, Lancet Psychiatry, vol.2, pp.403-415, 2015.

P. Hutton and P. J. Taylor, Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis, Psychol. Med, vol.44, pp.449-68, 2014.

. Inserm and . Psychothérapie, Trois approches évaluées

, Les éditions Inserm, 2004.

P. French and A. P. Morrison, Early detection and cognitive therapy for people at high risk of developing psychosis: a treatment approach, 2004.

A. P. Morrison, The interpretation of intrusions in psychosis: an integrative approach to hallucinations and delusions, Behav. Cogn. Psychother, vol.29, pp.257-76, 2001.

A. P. Morrison, P. French, L. Walford, S. W. Lewis, A. Kilcommons et al., Cognitive therapy for the prevention of psychosis in people at ultra-high risk: Randomised controlled trial, Br. J. Psychiatry, vol.185, pp.291-298, 2004.

J. Addington, I. Epstein, L. Liu, P. French, K. M. Boydell et al., A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosis, Schizophr. Res, vol.125, pp.54-61, 2011.

A. P. Morrison, P. French, S. Stewart, M. Birchwood, D. Fowler et al., Early detection and intervention evaluation for people at risk of psychosis: multisite randomised controlled trial, Br. Med. J, vol.344, p.2233, 2012.

M. Van-der-gaag, D. H. Nieman, J. Rietdijk, S. Dragt, H. K. Ising et al., Cognitive behavioral therapy for subjects at ultrahigh risk for developing psychosis: a randomized controlled clinical trial, Schizophr. Bull, vol.38, pp.1180-1188, 2012.

P. D. Mcgorry, B. Nelson, L. J. Phillips, H. P. Yuen, S. M. Francey et al., Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: twelve-month outcome, J. Clin. Psychiatry, vol.74, pp.349-56, 2013.

A. Bechdolf, M. Wagner, S. Ruhrmann, S. Harrigan, V. Putzfeld et al., Preventing progression to first-episode psychosis in early initial prodromal states, Br. J. Psychiatry, vol.200, pp.22-31, 2012.

H. J. Stain, S. Bucci, A. L. Baker, V. Carr, R. Emsley et al., A randomised controlled trial of cognitive behaviour therapy versus non-directive reflective listening for young people at ultra high risk of developing psychosis: The detection and evaluation of psychological therapy (DEPTh) trial, Schizophr. Res, vol.176, pp.212-221, 2016.

A. Bechdolf, H. Müller, H. Stützer, M. Lambert, A. Karow et al., PREVENT: A Randomized Controlled Trial for the Prevention of First-Episode Psychosis Comparing Cognitive-Behavior Therapy (CBT), Clinical Management, and Aripiprazole Combined and Clinical Management and Placebo Combined, Schizophr. Bull, vol.43, pp.56-63, 2017.

A. Bechdolf, H. Muller, H. Stutzer, M. Wagner, W. Maier et al., Rationale and Baseline Characteristics of PREVENT: A Second-Generation Intervention Trial in Subjects At-Risk (Prodromal) of Developing First-Episode Psychosis Evaluating Cognitive Behavior Therapy, Aripiprazole, and Placebo for the Prevention of Psychosis, Schizophr. Bull, vol.37, pp.111-132, 2011.

J. A. Hartmann, P. D. Mcgorry, S. J. Schmidt, G. P. Amminger, H. P. Yuen et al., Opening the Black Box of Cognitive-Behavioural Case Management in Clients with Ultra-High Risk for Psychosis, Psychother. Psychosom, vol.86, pp.292-301, 2017.

, Cognitive Remediation Experts Workshop, 2010.

, Centre ressource réhabilitation psychosociale et remédiation cognitive

. Réhabil and . Psychosoc, Remédiation Cogn

, Les fonctions cognitives -Association québécoise des neuropsychologues | Association québécoise des neuropsychologues

S. M. August, J. N. Kiwanuka, R. P. Mcmahon, and J. M. Gold, The MATRICS Consensus Cognitive Battery (MCCB): Clinical and Cognitive Correlates, Schizophr. Res, vol.134, pp.76-82, 2012.

E. Bora, A. Lin, S. J. Wood, A. R. Yung, P. D. Mcgorry et al., Cognitive deficits in youth with familial and clinical high risk to psychosis: a systematic review and meta-analysis, Acta Psychiatr. Scand, vol.130, pp.1-15, 2014.

P. Fusar-poli, G. Deste, R. Smieskova, S. Barlati, A. R. Yung et al., Cognitive functioning in prodromal psychosis: a meta-analysis, Arch. Gen. Psychiatry, vol.69, pp.562-71, 2012.

C. Mam-lam-fook, C. Danset-alexandre, L. Pedron, A. I. Gaillard, R. Krebs et al., Neuropsychology of subjects with ultra-high risk (UHR) of psychosis: A critical analysis of the literature, L'Encephale, vol.43, pp.241-53, 2017.

R. Van-donkersgoed, L. Wunderink, R. Nieboer, A. Aleman, and G. Pijnenborg, Social Cognition in Individuals at Ultra-High Risk for Psychosis: A Meta-Analysis, PloS One, vol.10, p.141075, 2015.

T. Y. Lee, S. B. Hong, N. Y. Shin, and J. S. Kwon, Social cognitive functioning in prodromal psychosis: A metaanalysis, Schizophr. Res, vol.164, pp.28-34, 2015.

L. B. Glenthøj, C. Hjorthøj, T. D. Kristensen, C. A. Davidson, and M. Nordentoft, The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review, NPJ Schizophr, vol.3, p.20, 2017.

S. Rauchensteiner, W. Kawohl, S. Ozgurdal, E. Littmann, Y. Gudlowski et al., Testperformance after cognitive training in persons at risk mental state of schizophrenia and patients with schizophrenia, Psychiatry Res, vol.185, pp.334-343, 2011.

C. I. Hooker, E. E. Carol, T. J. Eisenstein, H. Yin, S. H. Lincoln et al., A pilot study of cognitive training in clinical high risk for psychosis: initial evidence of cognitive benefit, Schizophr. Res, vol.157, pp.314-320, 2014.

D. Piskulic, M. Barbato, L. Liu, and J. Addington, Pilot study of cognitive remediation therapy on cognition in young people at clinical high risk of psychosis, Psychiatry Res, vol.225, pp.93-101, 2015.

R. Loewy, M. Fisher, D. A. Schlosser, B. Biagianti, B. Stuart et al., Intensive Auditory Cognitive Training Improves Verbal Memory in Adolescents and Young Adults at Clinical High Risk for Psychosis, Schizophr. Bull, vol.42, issue.1, pp.118-126, 2016.

J. Choi, M. Stevens, M. Deasy, L. C. Haber, M. J. Dewberry et al., Pupillometer-based Neurofeedback Cognitive Training to Improve Processing Speed and Social Functioning in Individuals at Clinical High Risk for Psychosis, Psychiatr. Rehabil. J, vol.40, pp.33-42, 2017.

L. J. Phillips, S. M. Francey, J. Edwards, and N. Mcmurray, Stress and psychosis: Towards the development of new models of investigation, Clin. Psychol. Rev, vol.27, pp.307-324, 2007.

M. P. O'brien, J. L. Gordon, C. E. Bearden, S. R. Lopez, A. Kopelowicz et al., Positive family environment predicts improvement in symptoms and social functioning among adolescents at imminent risk for onset of psychosis, Schizophr. Res, vol.81, pp.269-75, 2006.

D. J. Miklowitz, M. P. O'brien, D. A. Schlosser, J. Addington, K. A. Candan et al., Family-focused treatment for adolescents and young adults at high risk for psychosis: results of a randomized trial, J. Am. Acad. Child Adolesc. Psychiatry, vol.53, pp.848-58, 2014.

M. P. O'brien, D. J. Miklowitz, K. A. Candan, C. Marshall, I. Domingues et al., A randomized trial of family focused therapy with populations at clinical high risk for psychosis: effects on interactional behavior, J. Consult. Clin. Psychol, vol.82, pp.90-101, 2014.

W. R. Mcfarlane, B. Levin, L. Travis, F. L. Lucas, S. Lynch et al., Clinical and Functional Outcomes After 2 Years in the Early Detection and Intervention for the Prevention of Psychosis Multisite Effectiveness Trial, Schizophr. Bull, vol.41, pp.30-43, 2015.

N. Granö, M. Karjalainen, K. Ranta, M. Lindgren, M. Roine et al., Community-oriented familybased intervention superior to standard treatment in improving depression, hopelessness and functioning among adolescents with any psychosis-risk symptoms, Psychiatry Res, vol.237, pp.9-16, 2016.

A. Preti and M. Cella, Randomized-controlled trials in people at ultra high risk of psychosis: A review of treatment effectiveness, Schizophr. Res, vol.123, pp.30-36, 2010.

M. R. Stafford, H. Jackson, E. Mayo-wilson, A. P. Morrison, and T. Kendall, Early interventions to prevent psychosis: systematic review and meta-analysis, BMJ, vol.346, p.185, 2013.

M. Van-der-gaag, F. Smit, A. Bechdolf, P. French, D. H. Linszen et al., Preventing a first episode of psychosis: meta-analysis of randomized controlled prevention trials of 12 month and longer-term follow-ups, Schizophr. Res, vol.149, pp.56-62, 2013.

S. J. Schmidt, F. Schultze-lutter, B. G. Schimmelmann, N. P. Maric, R. Salokangas et al., EPA guidance on the early intervention in clinical high risk states of psychoses, Eur. Psychiatry, vol.30, pp.388-404, 2015.

M. Nordentoft, L. Petersen, P. Jeppesen, A. Thorup, M. Abel et al., OPUS: a randomised multicenter trial of integrated versus standard treatment for patients with a firstepisode psychosis--secondary publication

, Ugeskr. Laeger, vol.168, pp.381-385, 2006.

L. J. Phillips, B. Nelson, H. P. Yuen, S. M. Francey, M. Simmons et al., Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: study design and baseline characteristics, Aust. N. Z. J. Psychiatry, vol.43, pp.818-847, 2009.

A. R. Yung, L. J. Phillips, B. Nelson, S. M. Francey, H. Panyuen et al., Randomized controlled trial of interventions for young people at ultra high risk for psychosis: 6-month analysis, J. Clin. Psychiatry, vol.72, pp.430-470, 2011.

N. Tsujino, T. Nemoto, K. Morita, N. Katagiri, S. Ito et al., Long-term Efficacy and Tolerability of Perospirone for Young Help-seeking People at Clinical High Risk: a Preliminary Open Trial, Clin Psychopharmacol Neurosci, vol.11, pp.132-138, 2013.

M. P. O'brien, J. L. Zinberg, C. E. Bearden, M. Daley, T. A. Niendam et al., Psychoeducational multi-family group treatment with adolescents at high risk for developing psychosis, Early Interv. Psychiatry, vol.1, pp.325-357, 2007.

C. Davies, A. Cipriani, J. Ioannidis, J. Radua, D. Stahl et al., Lack of evidence to favor specific preventive interventions in psychosis: a network meta-analysis, World Psychiatry, vol.17, pp.196-209, 2018.

S. Woods, J. Saksa, M. Compton, M. Daley, R. Rajarethinam et al., Effects of Ziprasidone Versus Placebo in Patients at Clinical High Risk for Psychosis, Schizophr. Bull, vol.43, p.58, 2017.

D. Bosnjak-kuharic, I. Kekin, J. Hew, R. Kuzman, M. Puljak et al., Interventions for prodromal stage of psychosis, Cochrane Database Syst. Rev, 2019.

D. J. Devoe, M. S. Farris, P. Townes, and J. Addington, Attenuated psychotic symptom interventions in youth at risk of psychosis: A systematic review and meta-analysis, Early Interv. Psychiatry, vol.13, pp.3-17, 2019.

C. Davies, J. Radua, A. Cipriani, D. Stahl, U. Provenzani et al., Efficacy and Acceptability of Interventions for Attenuated Positive Psychotic Symptoms in Individuals at Clinical High Risk of Psychosis: A, Network Meta-Analysis. Front. Psychiatry, vol.9, p.187, 2018.

D. J. Devoe, M. S. Farris, P. Townes, and J. Addington, Interventions and social functioning in youth at risk of psychosis: A systematic review and meta-analysis, Early Interv. Psychiatry, vol.13, pp.169-80, 2019.

D. J. Devoe, A. Peterson, and J. Addington, Negative Symptom Interventions in Youth at Risk of Psychosis: A Systematic Review and Network Meta-analysis, Schizophr. Bull, vol.44, pp.807-830, 2018.

, Overview | Psychosis and schizophrenia in adults: prevention and management | Guidance | NICE

, Australian Clinical Guidelines for Early Psychosis -Second Edition Updated -Orygen, Revolution in Mind

, Canadian Treatment Guidelines for Individuals at Clinical High Risk of Psychosis

L. R. Valmaggia, M. Byrne, F. Day, M. R. Broome, L. Johns et al., Reduced duration of untreated psychosis and need for admission in patients who engage with mental health services in the prodromal phase, Br. J. Psychiatry J. Ment. Sci, vol.207, pp.130-134, 2015.

D. H. Nieman and P. D. Mcgorry, Detection and treatment of at-risk mental state for developing a first psychosis: making up the balance, Lancet Psychiatry, vol.2, pp.825-859, 2015.

D. H. Nieman, W. H. Rike, H. E. Becker, P. M. Dingemans, T. A. Van-amelsvoort et al., Prescription of antipsychotic medication to patients at ultra high risk of developing psychosis, Int. Clin. Psychopharmacol, vol.24, pp.223-231, 2009.

P. Fusar-poli, P. D. Mcgorry, and J. M. Kane, Improving outcomes of first-episode psychosis: an overview, World Psychiatry, vol.16, pp.251-65, 2017.

, Au moment d'être admis(e) à exercer la médecine

, Mon premier souci sera de rétablir, de préserver ou de promouvoir la santé dans tous ses éléments, physiques et mentaux, individuels et sociaux

, Je respecterai toutes les personnes, leur autonomie et leur volonté, sans aucune

, Même sous la contrainte, je ne ferai pas usage de mes connaissances contre les lois de l'humanité

, J'informerai les patients des décisions envisagées, de leurs raisons et de leurs

, Admis(e) dans l'intimité des personnes, je tairai les secrets qui me seront confiés

, J'apporterai mon aide à mes confrères

, Que les hommes et mes confrères m'accordent leur estime si je suis fidèle à mes