, Chez le patient 4, le séquençage ciblé n'a pas retrouvé dans la tumeur la mutation identifiée au niveau germinal. Pour éliminer l'existence d'une préférence allélique avec le couple d'amorces utilisé, nous avons « designé » un nouveau couple mais la mutation n'a toujours pas été retrouvée. Par ailleurs, le séquençage du gène entier n'a mis en évidence aucune anomalie ponctuelle, Nous avons mis en évidence une absence de LOH de MEN1 chez le patient 1 atteint d'un méningiome

, Un séquençage à haut débit par technique NGS a été réalisé sur les deux méningiomes

, La recherche de perte d'hétérozygotie du gène NF2 a été réalisée pour les 4 patients de

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