Systematic review: Kidney transplantation compared with dialysis in clinically relevant outcomes, Am J Transplant, 2011. ,
Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant, N Engl J Med, vol.341, issue.23, pp.1725-1755, 1999. ,
Causes of death after renal transplantation, Nephrol Dial Transplant, vol.16, issue.8, pp.1545-1554, 2001. ,
Cancer risk in patients on dialysis and after renal transplantation, Lancet, vol.355, issue.9218, pp.1886-1893, 2000. ,
Cancer after kidney transplantation in the United States, Am J Transplant, vol.4, issue.6, pp.905-918, 2004. ,
Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States, Am J Transplant, vol.16, issue.12, pp.3479-89, 2016. ,
Renal cell carcinoma in the native and allograft kidneys of renal transplant recipients, J Urol, vol.186, issue.1, pp.219-242, 2011. ,
Malignant tumors arising de novo in immunosuppressed organ transplant recipients, Transplantation, vol.14, issue.4, pp.407-424, 1972. ,
De novo malignancies after organ transplantation, Transplant Proc, vol.33, issue.1-2, pp.1858-1867, 2001. ,
Cancer incidence among Canadian kidney transplant recipients, Am J Transplant, vol.7, issue.4, pp.941-949, 2007. ,
Cumulative incidence of cancer after solid organ transplantation. Cancer, vol.119, pp.2300-2308, 2013. ,
Spectrum of cancer risk among US solid organ transplant recipients, JAMA, 2011. ,
Overall and cause-specific mortality in transplant recipients with a pretransplantation cancer history, vol.96, pp.297-305, 2013. ,
Outcomes of Solid Organ Transplant Recipients With Preexisting Malignancies in Remission, Transplantation ,
Malignancy-related mortality following kidney transplantation is common, Kidney Int, 2014. ,
Association between Pretransplant Cancer and Survival in Kidney Transplant Recipients, vol.101, pp.2599-605, 2017. ,
Kidney transplantation in patients with previous renal cancer: a critical appraisal of current evidence and guidelines ,
, Journal of Nephrology, vol.32, 2019.
Recurrence of Renal Cell Cancer After Renal Transplantation in a ,
, Transplantation, vol.102, issue.5, pp.860-867, 2018.
Cyclosporine induces cancer progression by a cell-autonomous mechanism, Nature, vol.397, issue.6719, pp.530-534, 1999. ,
Pro-and anti-cancer effects of immunosuppressive agents used in organ transplantation, Transplantation. Transplantation, vol.77, pp.1777-82, 2004. ,
Urological tumors in renal transplantation, Minerva Urol Nefrol ,
Lymphoproliferative Disease after Renal Transplantation in Australia and New Zealand, Transplantation, vol.80, issue.2, pp.193-200, 2005. ,
Rising incidence and aggressive nature of cutaneous malignancies after transplantation: An update on epidemiology, risk factors, management and surveillance, Surg Oncol, vol.24, issue.4, pp.345-52, 2015. ,
Immunosuppressive drugs in kidney transplantation: Impact on patient survival, and incidence of cardiovascular disease, malignancy and infection ,
Spectrum of cancer risk among US solid organ transplant recipients, JAMA -J Am Med Assoc, vol.306, issue.17, pp.1891-901, 2011. ,
,
, Prog Urol, vol.26, issue.15, pp.1094-113, 2016.
,
, Cancer Incidence Before and After Kidney Transplantation, JAMA, vol.296, issue.23, p.2823, 2006.
Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet, vol.370, pp.59-67, 2007. ,
Cancer in end-stage renal disease: Potential factors involved, American Journal of Nephrology. Am J Nephrol, vol.18, pp.89-95, 1998. ,
Unexpected neoplasia in autopsies: Potential implications for tissue and organ safety, Arch Pathol Lab Med, vol.133, issue.12, pp.1923-1954, 2009. ,
Cancer transmission from organ donors-unavoidable but low risk, Transplantation, vol.94, issue.12, pp.1200-1207, 2012. ,
Donor cancer transmission in kidney transplantation: A systematic review, American Journal of Transplantation, vol.13, pp.2645-52, 2013. ,
Primary kidney tumors before and after renal transplantation, Transplantation, vol.59, issue.4, pp.480-485, 1995. ,
Genomic instability in chronic renal failure patients, Environ Mol Mutagen, vol.53, issue.5, pp.343-352, 2012. ,
Advanced glycation end products in end-stage renal disease and their removal ,
Prevalence of acquired cystic kidney disease and tumors in native kidneys of renal transplant recipients: a prospective US study, Radiology, vol.195, issue.3, pp.667-71, 1995. ,
Renal neoplasias in patients receiving dialysis and renal transplantation: clinico-pathological features and p53 gene mutations. Transplantation [Internet, vol.68, pp.385-90, 1999. ,
Renal cell carcinoma in transplant recipients with acquired cystic kidney disease, Clin J Am Soc Nephrol, vol.2, issue.4, pp.750-756, 2007. ,
Renal cell carcinoma (RCC) arising in native kidneys of dialyzed and transplant patients: are they different entities? BJU Int, vol.110, pp.570-573, 2012. ,
Higher perioperative morbidity and in-hospital mortality in patients with end-stage renal disease undergoing nephrectomy for non-metastatic kidney cancer: A population-based analysis, BJU Int ,
, , vol.110, pp.183-90, 2020.
Features and outcomes of renal cell carcinoma of native kidneys in renal transplant recipients, BJU Int, 2010. ,
Renal cell carcinoma (RCC) in patients with end-stage renal disease exhibits many favourable clinical, pathologic, and outcome features compared with RCC in the general population, Eur Urol, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00577215
, , vol.60, pp.366-73, 2020.
Estimates of worldwide burden of cancer in 2008: GLOBOCAN, Int J Cancer, vol.127, issue.12, pp.2893-917, 2008. ,
,
The incidence and implications of renal cell carcinoma in cadaveric renal transplants at the time of organ recovery ,
, Transplantation, vol.67, issue.11, pp.1438-1478, 1999.
Renal cell carcinoma in renal graft recipients and donors: Incidence and consequence, Urol Int ,
Effectiveness and Harms of Using Kidneys with Small Renal Tumors from Deceased or Living Donors as a Source of Renal Transplantation: A Systematic Review ,
, European Urology Focus. Elsevier B.V, vol.5, pp.508-525, 2019.
Primary adenocarcinoma in a transplanted cadaveric kidney ,
, Transplantation, vol.46, issue.1, pp.157-165, 1988.
De Novo Kidney Graft Tumors: Results From a Multicentric Retrospective National Study, Am J Transplant ,
URL : https://hal.archives-ouvertes.fr/hal-00942810
Renal cell carcinoma of the grafted kidney: how to improve screening and graft tracking, Transplantation, vol.12, issue.12, pp.146-154, 2004. ,
Renal cell carcinoma in kidney allografts: a case series from a single center, Am J Transplant, 2005. ,
Occurrence of cancers in immunosuppressed organ transplant recipients, Clin Transpl, pp.147-58, 1998. ,
Solid Renal Masses in Transplanted Allograft Kidneys: A Closer Look at the Epidemiology and Management, American Journal of Transplantation, vol.17, pp.2775-81, 2017. ,
Renal cell carcinoma in kidney transplant recipients: Descriptive analysis and overview of a major German transplant center ,
, Futur Oncol, vol.15, issue.32, pp.3739-50, 2019.
The epidemiology of renal cell carcinoma, European Urology, vol.60, pp.615-636, 2011. ,
Nephron sparing surgery for de novo renal cell carcinoma in an allograft kidney: A case report, Int J Urol, vol.4, issue.6, pp.611-615, 1997. ,
Histopathology of surgically treated renal cell carcinoma: Survival differences by subtype and stage, J Urol, 2012. ,
,
, Histological Subtype is an Independent Predictor of Outcome for Patients With Renal Cell Carcinoma, J Urol, vol.183, issue.4, pp.1309-1325, 2010.
,
, European Association of Urology Guidelines on Renal Cell Carcinoma: The 2019 Update, Eur Urol, vol.75, issue.5, pp.799-810, 2019.
Correlation between symptom graduation, tumor characteristics and survival in renal cell carcinoma, Eur Urol, 2003. ,
Multicenter determination of optimal interobserver agreement using the Fuhrman grading system for renal cell carcinoma: Assessment of 241 patients with > 15-year follow-up, Cancer, vol.103, issue.3, pp.625-634, 2005. ,
Current Safety of Renal Allograft Biopsy with Indication in Adult Recipients. Med (United States), p.95, 2016. ,
Is there a contemporary role for percutaneous needle biopsy in the era of small renal masses? BJU Int, vol.109, pp.867-72, 2012. ,
Renal cell carcinoma co-existent with other renal disease: clinico-pathological features in pre-dialysis patients and those receiving dialysis or renal transplantation, Nephrol Dial Transplant, vol.19, issue.11, pp.2789-96, 2004. ,
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma, N Engl J Med, vol.374, issue.2, pp.135-180, 2016. ,
Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors, Oncotarget, vol.9, issue.43, pp.27039-58, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02135704
Nephron sparing surgery for de novo kidney graft tumor: Results from a multicenter national study, Am J Transplant, vol.14, issue.9, pp.2120-2125, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01727569
A national study of kidney graft tumor treatments: Toward ablative therapy. Surg (United States, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01732230
Renal cell recurrence for T1 tumors after laparoscopic partial nephrectomy, J Endourol, vol.27, issue.12, pp.1468-70, 2013. ,
Local Tumor Bed Recurrence Following Partial Nephrectomy in Patients with Small Renal Masses, J Urol, 2018. ,
Robot-assisted laparoscopic partial nephrectomy with renal artery clamping using an endovascular balloon catheter for an allograft kidney tumor: A new perspective to manage renal vascular control?, Am J Transplant, vol.19, issue.4, pp.1239-1279, 2019. ,
Robotic-assisted laparoscopic partial nephrectomy for a 7-cm mass in a renal allograft, Am J Transplant, vol.11, issue.10, pp.2242-2248, 2011. ,
Comparison of partial nephrectomy and percutaneous ablation for cT1 renal masses, Eur Urol, vol.67, issue.2, pp.252-261, 2015. ,
De novo renal tumors arising in kidney transplants: Midterm outcome after percutaneous thermal ablation, Radiology, vol.260, issue.3, pp.900-907, 2011. ,
Systematic review of ablative therapy for the treatment of renal allograft neoplasms, World Journal of Clinical Cases, vol.7, pp.2487-504, 2019. ,
Survival on dialysis post-kidney transplant failure: results from the Scientific Registry of Transplant Recipients, Am J Kidney Dis, vol.49, issue.2, pp.294-300, 2007. ,
,
, Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial, vol.87, pp.233-275, 2009.
Cancer and mTOR inhibitors in transplant recipients, vol.101, pp.45-55, 2017. ,
,
, Metastatic renal-cell carcinoma developing in two recipients of renal grafts derived from the same donor, Nephrol Dial Transplant, vol.10, issue.9, pp.1772-1776, 1995.
Metastatic RCC arising in a transplant kidney, Eur Radiol, vol.8, issue.8, pp.1441-1444, 1998. ,
De novo renal cell carcinoma of native and graft kidneys in renal transplant recipients, BJU Int ,
, , vol.108, pp.229-263, 2020.
EBPG Expert Group on Renal Transplantation. European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.6.3. Cancer risk after renal transplantation. Solid organ cancers: prevention and treatment, Nephrol Dial Transplant, vol.3, issue.2, pp.87-100, 2002. ,
There are no recommendations for the management of renal cell carcinoma (RCC) of the allograft. We carried out a multicentric retrospective national study. The data were collected in 32 French transplantation centers between, No Title), vol.56, p.806, 1988. ,
, Mean age at diagnostic was 50.1 years with a 2.24 men/women sex ratio. Mean size was 27.7mm. Eighty-two (78.8%), 108 (94.2%) and 57 (46.3%) were respectively low grade (Fuhrman 1-2), T1 stage and papillary carcinoma subtype. Ninety-six (78%) tumors were diagnosed by routine surveillance imaging. Mean time lapse between transplantation and RCC diagnosis was 143 months. Patients were treated by transplantectomy
, 2%) cases. The estimated 5-year cancer specific survival rate was 97%. Mean following time was 60.5 months. Most of RCC allografts are diagnosed incidentally. They were small, low grade with more papilla subtype than in general population. Conservative treatment is feasible and safe, it should be preferred when possible to avoid return to dialysis. Annual screening by imaging seems essential. KEY WORDS : Kidney Transplantation ; Kidney cancer ; Ablative therapy ; Nephrectomy ; Nephron sparing surgery