Skip to Main content Skip to Navigation
Master Thesis

Lymphome oculo-cérébral : étude rétrospective de 56 cas au CHU de Caen de janvier 2011 à septembre 2019, point de vue ophtalmologique

Abstract : Introduction: primary Lymphoma of the Central Nervous System (PCNSL) is located in the brain, spinal cord, meninges and eyes. The form located in the eye is also called primary vitreoretinal lymphoma. PCNSL is a rare cancer that accounts for 1% of lymphomas in France, and its ophthalmological involvement is exceptional. The main objective of this study is to analyse the characteristics of the patients cohort included in the LOC network in Caen. Material and method: retrospective study, including patients from the LOC network of the Caen University Hospital (PCNSL networks) from January 1, 2011 to September 30, 2019. Patients with an impairment outside the central nervous system were excluded. The characteristics analysed are clinical, paraclinical, as well as their initial treatment, overall survival and survival without recurrence. A comparison was made between patients with and without ocular impairment. Results: 56 patients were included. The median age was 66 years. The clinical signs most present were focal neurological signs. 20% of patients had vitreous haze. 80% of patients received systemic methotrexate chemotherapy. 11% of patients had an ocular relapse. Median follow-up was 32 months. The median progression-free survival was 18 months. The median overall survival was 29.7 months. Conclusion: in our study, patients without ocular damage were more likely to have a single lesion on MRI. There were no other significant differences between patients with and without ocular damage.
Complete list of metadatas

https://dumas.ccsd.cnrs.fr/dumas-02942398
Contributor : Ufr Santé Unicaen <>
Submitted on : Thursday, September 17, 2020 - 6:12:57 PM
Last modification on : Friday, December 18, 2020 - 3:36:40 AM
Long-term archiving on: : Friday, December 18, 2020 - 6:18:17 PM

Identifiers

  • HAL Id : dumas-02942398, version 1

Citation

Pierre-Alban Marty. Lymphome oculo-cérébral : étude rétrospective de 56 cas au CHU de Caen de janvier 2011 à septembre 2019, point de vue ophtalmologique. Médecine humaine et pathologie. 2020. ⟨dumas-02942398⟩

Share

Metrics

Record views

7

Files downloads

24