, Le cancer en chiffres | Fondation ARC pour la recherche sur le cancer

, Disponible sur: /le-cancer-en-chiffres

, Dernières données mondiales sur le cancer : le fardeau du cancer atteint 18,1 millions de nouveaux cas et 9,6 millions de décès par cancer en, vol.3, 2018.

A. A. Wright, N. L. Keating, J. Z. Ayanian, E. A. Chrischilles, K. L. Kahn et al., Family Perspectives on Aggressive Cancer Care Near the End of Life, JAMA. 19 janv, vol.315, issue.3, pp.284-92, 2016.

S. Mercadante, C. Adile, P. Ferrera, A. Cortegiani, and A. Casuccio, Symptom hyper-expression in advanced cancer patients with anxiety and depression admitted to an acute supportive/palliative care unit. Support Care Cancer Off J Multinatl Assoc Support Care Cancer, 2019.

A. B. Weir, K. M. Ryder, H. B. Niell, M. Muthia, and K. Clark, ICU deaths in advanced cancer patients: Reasonableness of ICU admissions, J Clin Oncol, vol.32, pp.199-199, 2014.

A. M. Esquinas and E. Pravinkumar, Intensive care unit mortality in solid tumor patients: is this predictable and preventable? Support Care Cancer, févr, vol.22, issue.2, pp.289-90, 2014.

C. C. Earle, E. R. Park, B. Lai, J. C. Weeks, J. Z. Ayanian et al., Identifying Potential Indicators of the Quality of End-of-Life Cancer Care From Administrative Data, J Clin Oncol. 15 mars, vol.21, issue.6, pp.1133-1141, 2003.

C. C. Earle, B. A. Neville, M. B. Landrum, J. Z. Ayanian, S. D. Block et al., Trends in the Aggressiveness of Cancer Care Near the End of Life, J Clin Oncol. 15 janv, vol.22, issue.2, pp.315-336, 2004.

G. Revon-rivière, P. V. Baumstarck, K. Bernard, C. André, N. Gentet et al., Highintensity end-of-life care among children, adolescents, and young adults with cancer who die in the hospital: A population-based study from the French national hospital database, Cancer. 26 mars, 2019.

J. S. Temel, J. A. Greer, A. Muzikansky, E. R. Gallagher, S. Admane et al., Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer

,

K. G. Wilson, H. M. Chochinov, G. Skirko, M. Allard, P. Chary et al., Depression and Anxiety Disorders in Palliative Cancer Care, J Pain Symptom Manage. févr, vol.33, issue.2, pp.118-147, 2007.

D. Hui, S. H. Kim, J. Roquemore, R. Dev, G. Chisholm et al., Impact of timing and setting of palliative care referral on quality of end-of-life care in cancer patients: Outpatient Palliative Care Referral, Cancer. 1 juin, vol.120, issue.11, pp.1743-1752, 2014.

S. S. Nasir, M. Muthiah, K. Ryder, K. Clark, H. Niell et al., ICU Deaths in Patients With Advanced Cancer: Reasonable Criteria to Decrease Potentially Inappropriate Admissions and Lack of Benefit of Advance Planning Discussions, Am J Hosp Palliat Med. mars, vol.34, issue.2, pp.173-182, 2017.

, Full Text PDF

D. Sur,

M. N. Verkissen, M. J. Hjermstad, S. V. Belle, S. Kaasa, L. Deliens et al., Quality of life and symptom intensity over time in people with cancer receiving palliative care: Results from the international European Palliative Care Cancer Symptom study, PLOS ONE, vol.14, issue.10, pp.222988-223004, 2019.

A. M. Romano, K. E. Gade, G. Nielsen, R. Havard, J. H. Harrison et al., Early Palliative Care Reduces End-of-Life Intensive Care Unit (ICU) Use but Not ICU Course in Patients with Advanced Cancer, The Oncologist. mars, vol.22, issue.3, pp.318-341, 2017.

J. Townsend, A. O. Frank, D. Fermont, S. Dyer, O. Karran et al., Terminal cancer care and patients' preference for place of death: a prospective study, BMJ. 1 sept, vol.301, issue.6749, pp.415-422, 1990.

S. J. Miller, N. Desai, N. Pattison, J. M. Droney, A. King et al., Quality of transition to end-of-life care for cancer patients in the intensive care unit, Ann Intensive Care. 25 juill, vol.5, issue.1, p.18, 2015.

T. J. Smith, S. Temin, E. R. Alesi, A. P. Abernethy, T. A. Balboni et al., American Society of Clinical Oncology Provisional Clinical Opinion: The Integration of Palliative Care Into Standard Oncology Care, J Clin Oncol. 10 mars, vol.30, issue.8, pp.880-887, 2012.

F. Goldwasser, P. Vinant, A. R. Rochigneux, P. Beaussant, Y. Huillard et al., Timing of palliative care needs reporting and aggressiveness of care near the end of life in metastatic lung cancer: A national registry-based study, Cancer, vol.124, issue.14, pp.3044-51, 2018.

C. Christodoulou, M. Rizos, E. Galani, K. Rellos, D. V. Skarlos et al., Performance Status (PS): A Simple Predictor of Short-term Outcome of Cancer Patients with Solid Tumors Admitted to the Intensive Care Unit (ICU), Anticancer Res. 7 janv, vol.27, issue.4C, pp.2945-2953, 2007.

J. W. Mack, A. Cronin, N. L. Keating, N. Taback, H. A. Huskamp et al., Associations Between End-of-Life Discussion Characteristics and Care Received Near Death: A Prospective Cohort Study, J Clin Oncol. 10 déc, vol.30, issue.35, pp.4387-95, 2012.

M. A. Bakitas, T. D. Tosteson, Z. Li, K. D. Lyons, J. G. Hull et al., Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial, J Clin Oncol. 1 mai, vol.33, issue.13, pp.1438-1483, 2015.

F. D. Ferris, E. Bruera, N. Cherny, C. Cummings, D. Currow et al., Palliative Cancer Care a Decade Later: Accomplishments, the Need, Next Steps-From the, J Clin Oncol. 20 juin, vol.27, issue.18, pp.3052-3060, 2009.

C. Andréjak, N. Terzi, S. Thielen, E. Bergot, G. Zalcman et al., Admission of advanced lung cancer patients to intensive care unit: A retrospective study of 76 patients, BMC Cancer. déc, vol.11, issue.1, p.159, 2011.

S. Miesfeldt, K. Murray, L. Lucas, C. Chang, D. Goodman et al., Association of Age, Gender, and Race with Intensity of End-of-Life Care for Medicare Beneficiaries with Cancer, J Palliat Med. mai, vol.15, issue.5, pp.548-54, 2012.

. De, Recommandations françaises du Comité de Cancérologie de l'AFU -Actualisation 2018-2020 : cancer de la prostate, 2018.

D. Sur,

, Disponible sur: /le-cancer-en-chiffres 2. Dernières données mondiales sur le cancer : le fardeau du cancer atteint 18,1 millions de nouveaux cas et 9,6 millions de décès par cancer en, vol.3, 2018.

A. A. Wright, N. L. Keating, J. Z. Ayanian, E. A. Chrischilles, K. L. Kahn et al., Family Perspectives on Aggressive Cancer Care Near the End of Life, JAMA. 19 janv, vol.315, issue.3, pp.284-92, 2016.

S. Mercadante, C. Adile, P. Ferrera, A. Cortegiani, and A. Casuccio, Symptom hyperexpression in advanced cancer patients with anxiety and depression admitted to an acute supportive/palliative care unit. Support Care Cancer Off J Multinatl Assoc Support Care Cancer, 2019.

A. B. Weir, K. M. Ryder, H. B. Niell, M. Muthia, and K. Clark, ICU deaths in advanced cancer patients: Reasonableness of ICU admissions, J Clin Oncol, vol.32, pp.199-199, 2014.

A. M. Esquinas and E. Pravinkumar, Intensive care unit mortality in solid tumor patients: is this predictable and preventable? Support Care Cancer, févr, vol.22, issue.2, pp.289-90, 2014.

C. C. Earle, E. R. Park, B. Lai, J. C. Weeks, J. Z. Ayanian et al., Identifying Potential Indicators of the Quality of End-of-Life Cancer Care From Administrative Data, J Clin Oncol. 15 mars, vol.21, issue.6, pp.1133-1141, 2003.

C. C. Earle, B. A. Neville, M. B. Landrum, J. Z. Ayanian, S. D. Block et al., Trends in the Aggressiveness of Cancer Care Near the End of Life, J Clin Oncol. 15 janv, vol.22, issue.2, pp.315-336, 2004.

G. Revon-rivière, P. V. Baumstarck, K. Bernard, C. André, N. Gentet et al., Highintensity end-of-life care among children, adolescents, and young adults with cancer who die in the hospital: A population-based study from the French national hospital database, Cancer. 26 mars, 2019.

J. S. Temel, J. A. Greer, A. Muzikansky, E. R. Gallagher, S. Admane et al., Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer

K. G. Wilson, H. M. Chochinov, G. Skirko, M. Allard, P. Chary et al., Depression and Anxiety Disorders in Palliative Cancer Care, Disponible sur, vol.33, pp.118-147, 2007.

D. Hui, S. H. Kim, J. Roquemore, R. Dev, G. Chisholm et al., Impact of timing and setting of palliative care referral on quality of end-of-life care in cancer patients: Outpatient Palliative Care Referral, Cancer. 1 juin, vol.120, issue.11, pp.1743-1752, 2014.

S. S. Nasir, M. Muthiah, K. Ryder, K. Clark, H. Niell et al., ICU Deaths in Patients With Advanced Cancer: Reasonable Criteria to Decrease Potentially Inappropriate Admissions and Lack of Benefit of Advance Planning Discussions, Am J Hosp Palliat Med. mars, vol.34, issue.2, pp.173-182, 2017.

, Full Text PDF

M. N. Verkissen, M. J. Hjermstad, S. V. Belle, S. Kaasa, L. Deliens et al., Quality of life and symptom intensity over time in people with cancer receiving palliative care: Results from the international European Palliative Care Cancer Symptom study, PLOS ONE, vol.14, issue.10, pp.222988-223031, 2019.

A. M. Romano, K. E. Gade, G. Nielsen, R. Havard, J. H. Harrison et al., Early Palliative Care Reduces End-of-Life Intensive Care Unit (ICU) Use but Not ICU Course in Patients with Advanced Cancer, The Oncologist. mars, vol.22, issue.3, pp.318-341, 2017.

J. Townsend, A. O. Frank, D. Fermont, S. Dyer, O. Karran et al., Terminal cancer care and patients' preference for place of death: a prospective study, BMJ. 1 sept, vol.301, issue.6749, pp.415-422, 1990.

S. J. Miller, N. Desai, N. Pattison, J. M. Droney, A. King et al., Quality of transition to end-of-life care for cancer patients in the intensive care unit, Ann Intensive Care. 25 juill, vol.5, issue.1, p.18, 2015.

T. J. Smith, S. Temin, E. R. Alesi, A. P. Abernethy, T. A. Balboni et al., American Society of Clinical Oncology Provisional Clinical Opinion: The Integration of Palliative Care Into Standard Oncology Care, J Clin Oncol. 10 mars, vol.30, issue.8, pp.880-887, 2012.

F. Goldwasser, P. Vinant, A. R. Rochigneux, P. Beaussant, Y. Huillard et al., Timing of palliative care needs reporting and aggressiveness of care near the end of life in metastatic lung cancer: A national registry-based study, Cancer, vol.124, issue.14, pp.3044-51, 2018.

C. Christodoulou, M. Rizos, E. Galani, K. Rellos, D. V. Skarlos et al., Performance Status (PS): A Simple Predictor of Short-term Outcome of Cancer Patients with Solid Tumors Admitted to the Intensive Care Unit (ICU), Anticancer Res. 7 janv, vol.27, issue.4C, pp.2945-2953, 2007.

J. W. Mack, A. Cronin, N. L. Keating, N. Taback, H. A. Huskamp et al., Associations Between End-of-Life Discussion Characteristics and Care Received Near Death: A Prospective Cohort Study, J Clin Oncol. 10 déc, vol.30, issue.35, pp.4387-95, 2012.

M. A. Bakitas, T. D. Tosteson, Z. Li, K. D. Lyons, J. G. Hull et al., Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial, J Clin Oncol. 1 mai, vol.33, issue.13, pp.1438-1483, 2015.

F. D. Ferris, E. Bruera, N. Cherny, C. Cummings, D. Currow et al., Palliative Cancer Care a Decade Later: Accomplishments, the Need, Next Steps-From the, J Clin Oncol. 20 juin, vol.27, issue.18, pp.3052-3060, 2009.

C. Andréjak, N. Terzi, S. Thielen, E. Bergot, G. Zalcman et al., Admission of advanced lung cancer patients to intensive care unit: A retrospective study of 76 patients, BMC Cancer. déc, vol.11, issue.1, p.159, 2011.

S. Miesfeldt, K. Murray, L. Lucas, C. Chang, D. Goodman et al., Association of Age, Gender, and Race with Intensity of End-of-Life Care for Medicare Beneficiaries with Cancer, J Palliat Med. mai, vol.15, issue.5, pp.548-54, 2012.

. De, Recommandations françaises du Comité de Cancérologie de l'AFU -Actualisation 2018-2020 : cancer de la prostate, 2018.

D. Sur,

R. Contexte,

. Le and F. De-décès-prématuré-en, En lien avec l'augmentation de la médicalisation des patients jusqu'à un stade avancé de leur cancer, de nombreuses admissions en unité de soins intensifs ne sont pas appropriées. Le but de notre étude est d'évaluer l'efficacité d'une prise en charge palliative adaptée sur la qualité du mourir des patients atteints d'un cancer solide avancé, en identifiant des facteurs raisonnables d'admission en soins intensifs, dans le dernier mois de vie. Méthode : Nous avons effectué une étude de cohorte rétrospective, basée sur la population de tous les patients âgés de plus de 16 ans atteints d'une tumeur solide décédés dans un hôpital français entre le 1er janvier 2013 et le 31 décembre 2016, qui ont été admis aux soins intensifs au cours du dernier mois ou de la dernière semaine avant le décès. L'étude repose sur la base de données des hôpitaux nationaux français (PMSI), dans laquelle des données administratives, cliniques et sociodémographiques ont été collectées

, 19%) ont été admis en unité de soins, vol.22, p.323

, 23%) sont décédés pendant leur séjour. Les principaux motifs d'admission étaient la septicémie, l'insuffisance respiratoire et les états de chocs. Plusieurs facteurs tels que le sexe, l'âge, l'indice de désavantage social et la présence de métastases étaient associés à l'admission en unité de soins, vol.15, p.245

, Les soins palliatifs étaient un facteur protecteur face à des soins invasifs en fin de vie

, Ces résultats suggèrent différentes façons de réduire les admissions en unité de soins intensifs en fin de vie et de préserver la qualité de vie. Cette considération est d'autant plus importante que les grandes avancées de l'immunothérapie et des thérapies ciblées apportent de l'espoir aux patients et aux médecins

, Mots-clés : soins palliatifs, fin de vie, cancer, tumeur solide, unité de soins intensifs