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Master Thesis

Évaluation de l’impact de la réforme des conditions de prescription et délivrance du zolpidem : étude pilote

Abstract : Zolpidem is a hypnotic drug related to benzodiazepines, used for the treatment of insomnia. It is the most commonly prescribed benzodiazepine among persons over 65 years of age. Due to problems of drug dependence, misuse and even diversion for criminal use, its prescription is subject to some of the regulatory framework applied for narcotics since April 10, 2017. The primary objective of this study was to measure the impact of the reform on a patients population under long-term Zolpidem (> 4 weeks) in a center of general medical practice. The secondary objective was to highlight possible transfers of prescriptions on other molecules for the treatment of insomnia. Materials and methods: a monocentric, retrospective and descriptive study of drug prescriptions before and after the reform, of a patient population consulting in the medical center of Sainte Marie la Mer, which was done by extracting data from computerized patient records. Results: 128 patients were included in the study. 78 patients (60.9% CI 95% 52.4 - 69.4) maintained the Zolpidem treatment and 50 (39.1% CI 95% 30.6 - 47.9 no longer had a Zolpidem prescription 6 months after the reform.44% of patients did not receive any substitutive treatment. The most used substitution treatments were for Zopiclone and Lormetazepam for 28% of patients, and 12% for Lormetazepam. No non-pharmacological interventions was found in the panel. Conclusion: The reform of prescription conditions of Zolpidem has proved effective in reducing the number of prescriptions. But will the fundamental problem (dependence, misuse and their consequences) not just be moved to other molecules? It would be interesting to promote the use of non-drug interventions for the treatment of insomnia. They currently offer the best benefit / risk ratio.
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Master Thesis
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Submitted on : Tuesday, February 2, 2021 - 12:06:53 PM
Last modification on : Saturday, July 3, 2021 - 3:16:35 AM


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  • HAL Id : dumas-02957436, version 1



Benjamin Combes. Évaluation de l’impact de la réforme des conditions de prescription et délivrance du zolpidem : étude pilote. Médecine humaine et pathologie. 2018. ⟨dumas-02957436⟩



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