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Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study, Lancet Oncol. févr, vol.16, issue.2, pp.187-99, 2015. ,
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Intensity-modulated radiotherapy vs. parotid-sparing 3D conformal radiotherapy. Effect on outcome and toxicity in locally advanced head and neck cancer, Strahlenther Onkol. mars, vol.189, issue.3, pp.223-232, 2013. ,
Value of intensity-modulated radiotherapy in Stage IV head-and-neck squamous cell carcinoma, Int J Radiat Oncol Biol Phys. 1 déc, vol.78, issue.5, pp.1373-80, 2010. ,
Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer, Int J Radiat Oncol Biol Phys. 15 mars, vol.70, issue.4, pp.1124-1133, 2008. ,
Early clinical outcomes and toxicity of intensity modulated versus conventional pelvic radiation therapy for locally advanced cervix carcinoma: a prospective randomized study, Int J Radiat Oncol Biol Phys, vol.87, issue.3, pp.542-550, 2013. ,
Intensity-modulated whole pelvic radiotherapy provides effective dosimetric outcomes for cervical cancer treatment with lower toxicities, Cancer Radiother. déc, vol.18, issue.8, pp.745-52, 2014. ,
Comparison of anisotropic aperture based intensity modulated radiotherapy with 3D-conformal radiotherapy for the treatment of large lung tumors, Radiother Oncol. févr, vol.102, issue.2, pp.268-73, 2012. ,
Comparison of inverse-planned three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for non-small-cell lung cancer, Int J Radiat Oncol Biol Phys. 1 mars, vol.67, issue.3, pp.735-776, 2007. ,
Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer, Int J Radiat Oncol Biol Phys. 15 mars, vol.58, issue.4, pp.1258-67, 2004. ,
Dosimetric advantages of intensity modulated radiation therapy in locally advanced lung cancer, Adv Radiat Oncol. mars, vol.2, issue.1, pp.6-11, 2017. ,
Feasibility of sparing lung and other thoracic structures with intensity-modulated radiotherapy for non-small-cell lung cancer, Int J Radiat Oncol Biol Phys. 15 mars, vol.58, issue.4, pp.1268-79, 2004. ,
High-dose radiotherapy in inoperable nonsmall cell lung cancer: comparison of volumetric modulated arc therapy, dynamic IMRT and 3D conformal radiotherapy, Med Dosim, vol.37, issue.4, pp.353-360, 2012. ,
Improving radiation conformality in the treatment of non-small cell lung cancer, Semin Radiat Oncol. juill, vol.20, issue.3, pp.171-178, 2010. ,
IMRT and 3D conformal radiotherapy with or without elective nodal irradiation in locally advanced NSCLC: A direct comparison of PET-based treatment planning, Strahlenther Onkol. févr, vol.192, issue.2, pp.75-82, 2016. ,
Limiting the risk of cardiac toxicity with esophagealsparing intensity modulated radiotherapy for locally advanced lung cancers, J Thorac Dis. mai, vol.8, issue.5, pp.942-951, 2016. ,
The superiority of hybridvolumetric arc therapy (VMAT) technique over double arcs VMAT and 3D-conformal technique in the treatment of locally advanced non-small cell lung cancer--a planning study, Radiother Oncol, vol.101, issue.2, pp.298-302, 2011. ,
Toxicity and dosimetric analysis of non-small cell lung cancer patients undergoing radiotherapy with 4DCT and image-guided intensity modulated radiotherapy: a regional centre's experience, J Med Radiat Sci. sept, vol.63, issue.3, pp.170-178, 2016. ,
Treatment planning comparison between conformal radiotherapy and helical tomotherapy in the case of locally advanced-stage NSCLC, Radiother Oncol. sept, vol.88, issue.3, pp.310-318, 2008. ,
Cardiac Exposure in the Dynamic Conformal Arc Therapy, Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy of Lung Cancer, PLoS ONE, vol.10, issue.12, p.144211, 2015. ,
Influence of technologic advances on outcomes in patients with unresectable, locally advanced non-small-cell lung cancer receiving concomitant chemoradiotherapy, Int J Radiat Oncol Biol Phys. 1 mars, vol.76, issue.3, pp.775-81, 2010. ,
Potential benefits of using non coplanar field and intensity modulated radiation therapy to preserve the heart in irradiation of lung tumors in the middle and lower lobes, Radiother Oncol. sept, vol.80, issue.3, pp.333-373, 2006. ,
Superior sulcus nonsmall cell lung carcinoma: A comparison of IMRT and 3D-RT dosimetry. Rep Pract Oncol Radiother, vol.21, pp.427-461, 2016. ,
Automated volumetric modulated Arc therapy treatment planning for stage III lung cancer: how does it compare with intensitymodulated radio therapy?, Int J Radiat Oncol Biol Phys. 1 sept, vol.84, issue.1, pp.69-76, 2012. ,
Volumetric modulated arc therapy for delivery of hypofractionated stereotactic lung radiotherapy: A dosimetric and treatment efficiency analysis, Radiother Oncol. mai, vol.95, issue.2, pp.153-160, 2010. ,
Intensity-modulated arc therapy: principles, technologies and clinical implementation, Phys Med Biol. 7 mars, vol.56, issue.5, pp.31-54, 2011. ,
, Intensity Modulated Radiation Therapy Collaborative Working Group. Intensity-modulated radiotherapy: current status and issues of interest, Int J Radiat Oncol Biol Phys, vol.15, issue.4, pp.880-914, 2001.
An isotoxic planning comparison study for stage II-III non-small cell lung cancer: is intensity-modulated radiotherapy the answer?, Clin Oncol (R Coll Radiol). août, vol.26, issue.8, pp.461-468, 2014. ,
Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: the Memorial Sloan-Kettering Cancer Center (MSKCC) experience, Radiother Oncol. avr, vol.87, issue.1, pp.17-23, 2008. ,
Intensity-Modulated Radiation Therapy May Improve Local-Regional Tumor Control for Locally Advanced Non-Small Cell Lung Cancer Compared With Three-Dimensional Conformal Radiation Therapy, Oncologist, vol.21, issue.12, pp.1530-1537, 2016. ,
Prediction of acute toxicity grade ? 3 in patients with locally advanced non-small-cell lung cancer receiving intensity modulated radiotherapy and concurrent low-dose Cisplatin, Clin Lung Cancer. sept, vol.14, issue.5, pp.541-549, 2013. ,
Treatment outcome and toxicity of intensity-modulated (chemo) radiotherapy in stage III non-small cell lung cancer patients, Radiat Oncol. 7 sept, vol.7, p.150, 2012. ,
A population-based comparative effectiveness study of radiation therapy techniques in stage III non-small cell lung cancer, Int J Radiat Oncol Biol Phys. 15 mars, vol.88, issue.4, pp.872-84, 2014. ,
Comparison of Toxicity Between Intensity-Modulated Radiotherapy and 3-Dimensional Conformal Radiotherapy for Locally Advanced Non-small-cell Lung Cancer, Clin Lung Cancer. janv, vol.17, issue.1, pp.18-23, 2016. ,
Intensity modulated radiotherapy for stage III non-small cell lung cancer in the United States: predictors of use and association with toxicities. Lung Cancer, vol.82, pp.252-261, 2013. ,
Effect of Radiation Therapy Techniques on Outcome in N3-positive IIIB Non-small Cell Lung Cancer Treated with Concurrent Chemoradiotherapy, Cancer Res Treat. janv, vol.48, issue.1, pp.106-120, 2016. ,
Comparison of 2 common radiation therapy techniques for definitive treatment of small cell lung cancer, Int J Radiat Oncol Biol Phys. 1 sept, vol.87, issue.1, pp.139-186, 2013. ,
Initial evaluation of treatment-related pneumonitis in advanced-stage non-small-cell lung cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy, Int J Radiat Oncol Biol Phys. 1 mai, vol.68, issue.1, pp.94-102, 2007. ,
An esophagus-sparing technique to limit radiation esophagitis in locally advanced non-small cell lung cancer treated by simultaneous integrated boost intensity-modulated radiotherapy and concurrent chemotherapy, Radiat Oncol. 17 juill, vol.13, issue.1, p.130, 2018. ,
Is IMRT Superior or Inferior to 3DCRT in Radiotherapy for NSCLC? A Meta-Analysis, PLoS ONE, vol.11, issue.4, p.151988, 2016. ,
New dose constraint reduces radiationinduced fatal pneumonitis in locally advanced non-small cell lung cancer patients treated with intensity-modulated radiotherapy, Acta Oncol, vol.54, issue.9, pp.1343-1352, 2015. ,
Comparative effectiveness of intensity-modulated versus 3D conformal radiation therapy among medicare patients with stage III lung cancer, J Thorac Oncol. déc, vol.9, issue.12, pp.1788-95, 2014. ,
Influence of conformal radiotherapy technique on survival after chemoradiotherapy for patients with stage III non-small cell lung cancer in the National Cancer Data Base, Cancer. 1 juill, vol.120, issue.13, pp.2060-2068, 2014. ,
Evaluating Intensity-Modulated Radiation Therapy in Locally Advanced Non-Small-Cell Lung Cancer: Results From the National Cancer Data Base, Clin Lung Cancer, vol.17, issue.5, pp.398-405, 2016. ,
Radiotherapy Group of European Organization for Research and Treatment of Cancer. Literature-based recommendations for treatment planning and execution in high-dose radiotherapy for lung cancer, Radiother Oncol. mai, vol.71, issue.2, pp.139-185, 2004. ,
Assessing respiration-induced tumor motion and internal target volume using four-dimensional computed tomography for radiotherapy of lung cancer, Int J Radiat Oncol Biol Phys. 1 juin, vol.68, issue.2, pp.531-571, 2007. ,
ESTRO ACROP guidelines for target volume definition in the treatment of locally advanced non-small cell lung cancer, Radiother Oncol, vol.127, issue.1, pp.1-5, 2018. ,
Evaluation of microscopic tumor extension in non-small-cell lung cancer for three-dimensional conformal radiotherapy planning, Int J Radiat Oncol Biol Phys, vol.48, issue.4, pp.1015-1039, 2000. ,
Target definition in the thorax and central nervous system, Semin Radiat Oncol. juill, vol.15, issue.3, pp.146-56, 2005. ,
, Cancer Radiother. sept, vol.20, pp.36-60, 2016.
Acute and late toxicities in thoracic irradiation ,
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The impact of regional nodal radiotherapy (dose/volume) on regional progression and survival in unresectable non-small cell lung cancer: an analysis of RTOG data, Lung Cancer. août, vol.41, issue.2, pp.207-221, 2003. ,
What margins are necessary for incorporating mediastinal nodal mobility into involvedfield radiotherapy for lung cancer?, Int J Radiat Oncol Biol Phys. 1 août, vol.53, issue.5, pp.1211-1216, 2002. ,
Elective nodal irradiation in the treatment of non-small-cell lung cancer with three-dimensional conformal radiation therapy, Int J Radiat Oncol Biol Phys. 1 juill, vol.50, issue.3, pp.681-686, 2001. ,
Incidental irradiation of nodal regions at risk during limited-field radiotherapy (RT) in dose-escalation studies in nonsmall cell lung cancer (NSCLC), Radiother Oncol. mai, vol.71, issue.2, pp.123-128, 2004. ,
Defining local-regional control and its importance in locally advanced non-small cell lung carcinoma, J Thorac Oncol. avr, vol.7, issue.4, pp.716-738, 2012. ,
Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC), Int J Radiat Oncol Biol Phys. 1 sept, vol.45, issue.2, pp.323-332, 1999. ,
Evaluating a Nomogram for the Development of Radiation Pneumonitis in Locally Advanced Non-Small Cell Lung Cancer Treated With 3D and Intensity Modulated Radiation Therapy, International Journal of Radiation Oncology ? Biology ? Physics. 1 sept, vol.90, issue.1, pp.161-163, 2014. ,
Comparison of 3D Conformal Radiation Therapy (3DCRT) and Intensity Modulated Radiation Therapy (IMRT) in Stage III Non-small Cell Lung Cancer (NSCLC), International Journal of Radiation Oncology ? Biology ? Physics, vol.84, issue.3, pp.597-605, 2012. ,
Algorithms used in heterogeneous dose calculations show systematic differences as measured with the Radiological Physics Center's anthropomorphic thorax phantom used for RTOG credentialing, Int J Radiat Oncol Biol Phys. 1 janv, vol.85, issue.1, pp.95-100, 2013. ,
Accuracy of dose calculation algorithms for static and rotational IMRT of lung cancer: A phantom study, Phys Med. juin, vol.31, issue.4, pp.382-90, 2015. ,
Optimal image-guidance scenario with cone-beam computed tomography in conventionally fractionated radiotherapy for lung tumors, Am J Clin Oncol. juin, vol.33, issue.3, pp.276-80, 2010. ,
Ten Haken RK. A method for incorporating organ motion due to breathing into 3D dose calculations, Med Phys. mai, vol.26, issue.5, pp.715-735, 1999. ,
Evaluation of tumor motion effects on dose distribution for hypofractionated intensity-modulated radiotherapy of non-small-cell lung cancer, J Appl Clin Med Phys. 8 juin, vol.11, issue.3, p.3182, 2010. ,
Dosimetric investigation of high dose rate, gated IMRT, Med Phys, vol.35, issue.11, pp.5079-87, 2008. ,
The effects of tumor motion on planning and delivery of respiratory-gated IMRT, Med Phys. juin, vol.30, issue.6, pp.1052-66, 2003. ,
Effects of intra-fraction motion on IMRT dose delivery: statistical analysis and simulation, Phys Med Biol. 7 juill, vol.47, issue.13, pp.2203-2223, 2002. ,
Effects of organ motion on IMRT treatments with segments of few monitor units, Med Phys. mars, vol.34, issue.3, pp.923-957, 2007. ,
Measurement of the interplay effect in lung IMRT treatment using EDR2 films, J Appl Clin Med Phys, vol.28, issue.4, pp.33-42, 2006. ,
Influence of intrafractional breathing movement in step-and-shoot IMRT, Phys Med Biol. 21 juin, vol.49, issue.12, pp.175-179, 2004. ,
Respiration gated radiotherapy treatment: a technical study, Phys Med Biol. janv, vol.41, issue.1, pp.83-91, 1996. ,
Interfractional anatomic variation in patients treated with respiration-gated radiotherapy, J Appl Clin Med Phys, vol.6, issue.2, pp.19-32, 2005. ,
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial, Lancet Oncol. mars, vol.16, issue.3, pp.257-65, 2015. ,
Nivolumab Versus Docetaxel in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer: Two-Year Outcomes From Two Randomized, Open-Label, Phase III Trials (CheckMate 017 and CheckMate 057), J Clin Oncol. 10 déc, vol.35, issue.35, pp.3924-3957, 2017. ,
Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer, N Engl J Med, vol.16, issue.20, pp.1919-1948, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01753457
Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC, N Engl J Med, vol.13, issue.24, pp.2342-50, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02284390
Phase 1 Trial of Pembrolizumab Administered Concurrently With Chemoradiotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Nonrandomized Controlled Trial, JAMA Oncol, vol.20, issue.2020 ,
Intra thoracic anatomical changes in lung cancer patients during the course of radiotherapy, Radiother Oncol. déc, vol.113, issue.3, pp.392-399, 2014. ,
A Current Review of Dose-escalated Radiotherapy in Locally Advanced Non-small Cell Lung Cancer, Radiol Oncol. 3 mars, vol.53, issue.1, pp.6-14, 2019. ,
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, Au moment d'être admis(e) à exercer la médecine, je promets et je jure d'être fidèle aux lois de l'honneur et de la probité
, Mon premier souci sera de rétablir, de préserver ou de promouvoir la santé dans tous ses éléments, physiques et mentaux, individuels et sociaux
, Je respecterai toutes les personnes, leur autonomie et leur volonté, sans aucune discrimination selon leur état ou leurs convictions. J'interviendrai pour les protéger si elles sont affaiblies, vulnérables ou menacées dans leur intégrité ou leur dignité. Même sous la contrainte
, Je ne tromperai jamais leur confiance et n'exploiterai pas le pouvoir hérité des circonstances pour forcer les consciences
, Je ne me laisserai pas influencer par la soif du gain ou la recherche de la gloire
, Reçu(e) à l'intérieur des maisons, je respecterai les secrets des foyers et ma conduite ne servira pas à corrompre les moeurs. Je ferai tout pour soulager les souffrances. Je ne prolongerai pas abusivement les agonies
, Je n'entreprendrai rien qui dépasse mes compétences. Je les entretiendrai et les perfectionnerai pour assurer au mieux les services qui me seront demandés
, J'apporterai mon aide à mes confrères ainsi qu'à leurs familles dans l'adversité
, Que les hommes et mes confrères m'accordent leur estime si je suis fidèle à mes promesses ; que je sois déshonoré(e) et méprisé(e) si j'y manque