T. Russo, G. Felzani, and C. Marini, Stroke in the very old: a systematic review of studies on incidence, outcome, and resource use, J Aging Res, p.108785, 2011.

G. Howard and D. C. Goff, Population shifts and the future of stroke: forecasts of the future burden of stroke, Ann N Y Acad Sci. sept, vol.1268, pp.14-20, 2012.

Y. Béjot, H. Bailly, M. Graber, L. Garnier, A. Laville et al., Impact of the Ageing Population on the Burden of Stroke: The Dijon Stroke Registry, Neuroepidemiology, vol.52, issue.1-2, pp.78-85, 2019.

J. Emberson, K. R. Lees, P. Lyden, L. Blackwell, G. Albers et al., Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials, Lancet Lond Engl, vol.384, issue.9958, pp.1929-1964, 2014.

M. Goyal, B. K. Menon, W. H. Van-zwam, D. Dippel, P. J. Mitchell et al., Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials, Lancet Lond Engl. 23 avr, vol.387, pp.1723-1754, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01876049

E. J. Duffis, W. He, C. J. Prestigiacomo, and C. D. Gandhi, Endovascular treatment for acute ischemic stroke in octogenarians compared with younger patients: a meta-analysis, Int J Stroke Off J Int Stroke Soc. avr, vol.9, issue.3, pp.308-320, 2014.

S. Son, D. Kang, Y. Hwang, Y. Kim, and Y. Kim, Efficacy, safety, and clinical outcome of modern mechanical thrombectomy in elderly patients with acute ischemic stroke, Acta Neurochir, vol.159, issue.9, pp.1663-1672, 2017.

C. A. Hilditch, P. Nicholson, M. H. Murad, A. Rabinstein, J. Schaafsma et al., Endovascular Management of Acute Stroke in the Elderly: A Systematic Review and Meta-Analysis, AJNR Am J Neuroradiol, vol.39, issue.5, pp.887-91, 2018.

A. Alawieh, R. M. Starke, A. R. Chatterjee, A. Turk, R. De-leacy et al., Outcomes of endovascular thrombectomy in the elderly: a « real-world » multicenter study, J Neurointerventional Surg, 2018.

J. Papassin, I. M. Favre-wiki, T. Atroun, F. Tahon, K. Boubagra et al., Patient eligibility for thrombectomy after acute stroke: Northern French Alps database analysis, Rev Neurol, vol.173, issue.4, pp.216-237, 2017.

. Mr-clean-investigators, P. S. Fransen, D. Beumer, O. A. Berkhemer, L. A. Van-den-berg et al., MR CLEAN, a multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands: study protocol for a randomized controlled trial, Trials. déc, vol.15, issue.1, p.343, 2014.

M. Goyal, A. M. Demchuk, B. K. Menon, M. Eesa, J. L. Rempel et al., Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke, N Engl J Med. 12 mars, vol.372, issue.11, pp.1019-1049, 2015.

T. G. Jovin, A. Chamorro, E. Cobo, M. A. De-miquel, C. A. Molina et al., Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke, N Engl J Med. 11 juin, vol.372, issue.24, pp.2296-306, 2015.

J. L. Saver, M. Goyal, A. Bonafe, H. Diener, E. I. Levy et al., Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke, N Engl J Med. 11 juin, vol.372, issue.24, pp.2285-95, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02007226

B. Campbell, P. J. Mitchell, T. J. Kleinig, H. M. Dewey, L. Churilov et al., Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection, N Engl J Med. 12 mars, vol.372, issue.11, pp.1009-1027, 2015.

S. Bracard, X. Ducrocq, J. L. Mas, M. Soudant, C. Oppenheim et al., Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial, Lancet Neurol, vol.15, issue.11, pp.1138-1185, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01825521

Y. Liu, H. Zhao, J. Zhou, Q. Wang, Z. Chen et al., Mild Stroke and Advanced Age Are the Major Reasons for Exclusion from Thrombolysis in Stroke Patients

, Hours. J Stroke Cerebrovasc Dis. juill, vol.23, issue.6, pp.1571-1577, 2014.

M. Shamy and C. S. Jaigobin, The complexities of acute stroke decision-making: A survey of neurologists, Neurology. 24 sept, vol.81, issue.13, pp.1130-1133, 2013.

C. Gumbinger, B. Reuter, W. Hacke, T. Sauer, I. Bruder et al., Restriction of therapy mainly explains lower thrombolysis rates in reduced stroke service levels, Neurology. 24 mai, vol.86, issue.21, pp.1975-83, 2016.

M. A. Khan, G. L. Baird, D. Miller, A. Patel, S. Tsekhan et al., Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort, J NeuroInterventional Surg. août, vol.9, issue.8, pp.727-758, 2017.

G. Yiin, D. Howard, N. Paul, L. Li, R. Luengo-fernandez et al., Age-Specific Incidence, Outcome, Cost, and Projected Future Burden of Atrial Fibrillation-Related Embolic Vascular Events: A Population-Based Study, Circulation, vol.130, issue.15, pp.1236-1280, 2014.

M. Ribo, A. Flores, E. Mansilla, M. Rubiera, A. Tomasello et al., Age-adjusted infarct volume threshold for good outcome after endovascular treatment, J NeuroInterventional Surg. juill, vol.6, issue.6, pp.418-440, 2014.

A. Sharobeam, D. J. Cordato, N. Manning, A. Cheung, J. Wenderoth et al., Functional Outcomes at 90 Days in Octogenarians Undergoing Thrombectomy for Acute Ischemic Stroke: A Prospective Cohort Study and Meta-Analysis, Front Neurol, vol.10, p.254, 2019.

Y. Tajima, M. Hayasaka, K. Ebihara, D. Kawauchi, and S. Suda, Thrombectomy in Octogenarians in the Era of Stent Retriever: Is an Age Limit Necessary?, J Neuroendovascular Ther, vol.11, issue.11, pp.563-572, 2017.

R. I. Lindley, J. M. Wardlaw, W. N. Whiteley, G. Cohen, L. Blackwell et al., Alteplase for Acute Ischemic Stroke, p.12

P. Sandercock, J. M. Wardlaw, R. I. Lindley, M. Dennis, and G. Cohen, The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial, Lancet Lond Engl. 23 juin, vol.379, issue.9834, pp.2352-63, 2012.

R. Behrouz, J. Masjuán-vallejo, R. Vera, J. Z. Willey, M. Zedet et al., Outcomes of Nonagenarians with Acute Ischemic Stroke Treated with Intravenous Thrombolytics, J Stroke Cerebrovasc Dis Off J Natl Stroke Assoc. janv, vol.27, issue.1, pp.246-56, 2018.

M. Ajay, W. Xiao, P. Seyedmehdi, M. Charles, C. Forman-howard et al., Comparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients, Stroke. 14 mars, vol.0, issue.0, 2019.

L. Bouc, R. Clarençon, F. Meseguer, E. Lapergue, B. Consoli et al., Efficacy of Endovascular Therapy in Acute Ischemic Stroke Depends on Age and Clinical Severity, Stroke. juill, vol.49, issue.7, pp.1686-94, 2018.

E. M. Arsava, R. Rahman, J. Rosand, J. Lu, E. E. Smith et al., Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke, Neurology. 21 avr, vol.72, issue.16, pp.1403-1413, 2009.

A. Popa-wagner, S. T. Carmichael, Z. Kokaia, C. Kessler, and L. C. Walker, The Response of the Aged Brain to Stroke: Too Much, Too Soon?, Curr Neurovasc Res. 1 août, vol.4, issue.3, pp.216-243, 2007.

V. Darsalia, U. Heldmann, O. Lindvall, and Z. Kokaia, Stroke-Induced Neurogenesis in Aged Brain, Stroke. août, vol.36, issue.8, pp.1790-1795, 2005.

F. Sallustio, G. Koch, C. Motta, M. Diomedi, F. Alemseged et al., Efficacy and Safety of Mechanical Thrombectomy in Older Adults with Acute Ischemic Stoke, J Am Geriatr Soc. août, vol.65, issue.8, pp.1816-1836, 2017.

E. Bluhmki, T. Danays, G. Biegert, W. Hacke, and K. R. Lees, Alteplase for Acute Ischemic Stroke in Patients Aged >80 Years: Pooled Analyses of Individual Patient Data, Stroke, vol.2, issue.2020

D. Sur,

A. Alawieh, A. Chatterjee, W. Feng, G. Porto, J. Vargas et al., Thrombectomy for acute ischemic stroke in the elderly: a « real world » experience, J Neurointerventional Surg. déc, vol.10, issue.12, pp.1209-1226, 2018.

S. Sagnier, P. Galli, M. Poli, S. Debruxelles, P. Renou et al., The impact of intravenous thrombolysis on outcome of patients with acute ischemic stroke after 90 years old, BMC Geriatr. 25 août, vol.16, p.156, 2016.

R. V. Chandra, T. M. Leslie-mazwi, D. C. Oh, Z. A. Chaudhry, B. P. Mehta et al., Elderly Patients Are at Higher Risk for Poor Outcomes After Intra-Arterial Therapy, Stroke. sept, vol.43, issue.9, pp.2356-61, 2012.

N. H. Mueller-kronast, O. O. Zaidat, M. T. Froehler, R. Jahan, M. A. Aziz-sultan et al., Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke: Primary Results of the STRATIS Registry, Stroke, vol.48, issue.10, pp.2760-2768, 2017.

W. Zhang, S. Coote, T. Frost, H. M. Dewey, and P. Choi, Acute Stroke Patients With Mild-to-Moderate Pre-existing Disability Should Be Considered for Thrombolysis Treatment, J Stroke Cerebrovasc Dis Off J Natl Stroke Assoc. oct, vol.27, issue.10, pp.2707-2718, 2018.

S. Figueiredo, A. Carvalho, M. Rodrigues, A. Cunha, L. Paredes et al., Endovascular Stroke Treatment of Patients Over 80 Years Old: Cumulative Evidence from the « Real World, J Stroke Cerebrovasc Dis Off J Natl Stroke Assoc. déc, vol.26, issue.12, pp.2949-53, 2017.

Q. Wu, Q. Li, C. Huang, Y. Li, V. Wolff et al., Efficacy and Safety of Endovascular Thrombectomy for Ischemic Stroke in Nonagenarians, Eur Neurol, vol.81, issue.3-4, pp.174-81, 2019.

D. F. Young-saver, J. Gornbein, S. Starkman, and J. L. Saver, Magnitude of Benefit of Combined Endovascular Thrombectomy and Intravenous Fibrinolysis in Large Vessel Occlusion Ischemic Stroke, Stroke. sept, vol.50, issue.9, pp.2433-2473, 2019.

B. Campbell, C. Majoie, G. W. Albers, B. K. Menon, N. Yassi et al., Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data, Lancet Neurol. janv, vol.18, issue.1, pp.46-55, 2019.

A. Alawieh, F. Zaraket, M. B. Alawieh, A. R. Chatterjee, and A. Spiotta, Using machine learning to optimize selection of elderly patients for endovascular thrombectomy, J Neurointerventional Surg. 2 févr, 2019.