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Master Thesis

La consommation d’alcool prévient l’évolution structurale dans la polyarthrite rhumatoïde : analyse systématique de la littérature et méta analyse

Abstract : Previous meta-analyses showed that a low to moderate alcohol consumption could decrease the risk of developing rheumatoid arthritis. Moreover, a moderate use of alcohol in man was in favor of a better radiographic score of joint/articular destruction. We performed a systematic review in three data bases PubMed, Cochrane and Embase on the impact of alcohol consumption on structural damage of RA patients. 1081 articles were screened, 1093 were excluded after reading the titles and abstracts. Finally, 4 articles were included in the meta-analysis.It was retrospective studies on American, swiss, british and French cohorts, using different radiographic scores. Patients were categorized according to their alcohol consumption at baseline: occasional consumption < 1 unit per day, moderate consumption 1 per day, high consumption > 1 per day. We compared each group of consumers (occasional, moderate, high) to the abstinent patients, and the moderate consumers to the excessive consumers. Then, sub groups analyses according to gender were made. No significative difference was found in radiographic scores between abstinent versus alcohol consumers nor abstinent and moderate to high consumers. These results were found in three groups: all gender, among women and among men. However, men with moderate alcohol consumption had less structural damage compared to the abstinent patients. Moderate alcohol consumption could decrease articular destruction of men with RA.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02978537
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Submitted on : Thursday, November 12, 2020 - 9:50:18 AM
Last modification on : Tuesday, November 24, 2020 - 4:00:15 PM

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Marie-Charlotte Desmottes. La consommation d’alcool prévient l’évolution structurale dans la polyarthrite rhumatoïde : analyse systématique de la littérature et méta analyse. Médecine humaine et pathologie. 2020. ⟨dumas-02978537⟩

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