, Quelle est l'importance de la raideur de votre articulation lorsque vous vous levez le matin ?

, Quelle est l'importance de la raideur de votre articulation lorsque vous bougez après vous être assis, couché ou reposé durant la journée ? 3. WOMAC Domaine fonction : quelle est l'importance de la difficulté que vous éprouvez à

, Descendre les escaliers ?

, Monter les escaliers ?

, Vous relever de la position assise ?

, Vous tenir debout ?

, Vous pencher en avant ?

, Marcher en terrain plat ?

, Entrer et sortir d'une voiture ?

, Faire vos courses ?

, Enlever vos collants ou vos chaussettes ?

, Vous étendre sur le lit ?

, Entrer ou sortir d'une baignoire ? 17. Vous asseoir ?

, Vous asseoir et vous relever des toilettes ?

, Faire le ménage " à fond " de votre domicile ?

, Faire l'entretien quotidien de votre domicile ? Annexe 10: Comparaison des critères de douleur et des scores cliniques entre le groupe PRP

C. Cooper, « Mechanical and constitutional risk factors for symptomatic knee osteoarthritis: differences between medial tibiofemoral and patellofemoral disease, J. Rheumatol, vol.21, issue.2, pp.307-313, 1994.

, Inserm -La science pour la santé, vol.20, 2019.

T. Lagorce, J. Buxeraud, X. Guillot, and . Comprendre, Actual. Pharm, vol.55, pp.18-22, 2016.

F. Guillemin, « Prevalence of symptomatic hip and knee osteoarthritis: a two-phase population-based survey1, Osteoarthritis Cartilage, vol.19, issue.11, pp.1314-1322, 2011.

D. Pereira, B. Peleteiro, J. Araújo, J. Branco, R. A. Santos et al., « The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review, Osteoarthritis Cartilage, vol.19, pp.1270-1285, 2011.

L. Murphy, « Lifetime risk of symptomatic knee osteoarthritis, Arthritis Rheum, vol.59, issue.9, pp.1207-1213, 2008.

«. Collège, Français des Enseignants en Rhumatologie(COFER), 2019.

J. Sellam and F. Berenbaum, The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis, Nat. Rev. Rheumatol, vol.6, issue.11, pp.625-635, 2010.

X. Ayral, E. H. Pickering, T. G. Woodworth, N. Mackillop, and M. Dougados, Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritisresults of a 1 year longitudinal arthroscopic study in 422 patients, Osteoarthritis Cartilage, vol.13, issue.5, pp.361-367, 2005.

C. Sanchez, O. Gabay, C. Salvat, Y. E. Henrotin, and F. Berenbaum, « Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts, Osteoarthritis Cartilage, vol.17, issue.4, pp.473-481, 2009.

R. Altman, « Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee », Arthritis Rheum, vol.29, issue.8, pp.1039-1049, 1986.

P. Ravaud and M. Dougados, « Dkfinition et Cpidkmiologie de la gonarthrose, p.8

C. G. Peterfy, « Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis, Osteoarthritis Cartilage, vol.12, issue.3, pp.177-190, 2004.

P. R. Kornaat, « MRI assessment of knee osteoarthritis: Knee Osteoarthritis Scoring System (KOSS)--inter-observer and intra-observer reproducibility of a compartment-based scoring system, Skeletal Radiol, vol.34, issue.2, pp.95-102, 2005.

D. J. Hunter, G. H. Lo, D. Gale, A. J. Grainger, A. Guermazi et al., « The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston-Leeds Osteoarthritis Knee Score) », Ann. Rheum. Dis, vol.67, issue.2, pp.206-211, 2008.

D. J. Hunter, « Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score), Osteoarthritis Cartilage, vol.19, issue.8, pp.990-1002, 2011.

N. Bellamy, « Recommendations for a Core Set of Outcome Measures for Future Phase III Clinical Trials in Knee, Hip, and Hand Osteoarthritis. Consensus Development at OMERACT III », J. Rheumatol, p.5

F. Tubach, Using patients' and rheumatologists' opinions to specify a short form of the WOMAC function subscale, Ann. Rheum. Dis, vol.64, issue.1, pp.75-79, 2005.

«. Koosfrench and ». Pdf,

A. V. Perruccio, « The development of a short measure of physical function for knee OA KOOS-Physical Function Shortform (KOOS-PS) -an OARSI/OMERACT initiative », Osteoarthritis Cartilage, vol.16, pp.542-550, 2008.

R. D. Crosby, R. L. Kolotkin, and G. R. Williams, « Defining clinically meaningful change in health-related quality of life, J. Clin. Epidemiol, vol.56, issue.5, pp.395-407, 2003.

J. Lin, W. Zhang, A. Jones, and M. Doherty, « Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials, BMJ, vol.329, p.324, 2004.

«. Vidal--gonarthrose, , 2019.

D. Baron and P. L. Goff, Place des corticoïdes en intra-articulaire chez l'adulte, vol.1, pp.39673-39674, 2006.

C. Chapelle, « Les injections intra-articulaires », Rev Med Brux, p.7, 2015.

, « Thériault -2006 -de substances corticoïdes

«. Bellamy, 2006 -Intraarticular corticosteroid for treatment of ost

«. Bannuru, 2009 -Therapeutic trajectory of hyaluronic acid versus c

«. Jüni, 2015 -Intra-articular corticosteroid for knee osteoarthr

«. Nguyen, 2016 -Evidence and recommendations for use of intra-arti

W. Zhang, « OARSI recommendations for the management of hip and knee osteoarthritis, Osteoarthritis Cartilage, vol.18, issue.4, pp.476-499

T. E. Mcalindon, « OARSI guidelines for the non-surgical management of knee osteoarthritis, Osteoarthritis Cartilage, vol.22, issue.3, pp.363-388, 2014.

M. C. Hochberg, College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee », Arthritis Care Res, vol.64, issue.4, pp.465-474

». «-arthrose, Inserm -La science pour la santé, 2019.

A. J. Kompel, F. W. Roemer, A. M. Murakami, L. E. Diaz, M. D. Crema et al., « Intra-articular Corticosteroid Injections in the Hip and Knee: Perhaps Not as Safe as We Thought? », Radiology, vol.293, pp.656-663

C. Nguyen, M. Lefèvre-colau, S. Poiraudeau, and F. Rannou, « Evidence and recommendations for use of intra-articular injections for knee osteoarthritis, Ann. Phys. Rehabil. Med, vol.59, issue.3, pp.184-189, 2016.

P. Richette, « Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias, RMD Open, vol.1, issue.1, pp.71-000071, 2015.

«. , , 2019.

«. Arthrose and . Genou, déremboursement effectif d'OSTENIL et d'ARTHRUM à partir du 1er décembre, 2017.

, « Question n°99179 -Assemblée nationale, vol.12, 2020.

V. Nair, C. Desouza, A. Chaudhary, H. Hurkat, and E. S. George, « Management of knee osteoarthritis: Knee lavage combined with intra articular injections of methyl prednisolone », Int. J. Orthop. Sci, vol.4, issue.2, pp.169-174, 2018.

. «-haute-autorité-de-santé--hanche and . Genou, , 2019.

J. T. Evans, J. P. Evans, R. W. Walker, A. W. Blom, M. R. Whitehouse et al., « How long does a hip replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up, The Lancet, vol.393, issue.18, pp.31665-31674

, Code de la sécurité sociale -Article L161-37, pp.161-198

S. Moussaoui, S. Lucas, P. Zorzi, C. L. Saulnier, and J. Trouvin, « Cadre réglementaire de la thérapie cellulaire, Bull. Cancer (Paris), vol.90, issue.8, pp.779-788, 2003.

«. Le-contexte-réglementaire-des-médicaments-de-thérapie-innovante--ansm, Agence nationale de sécurité du médicament et des produits de santé, 2019.

. «-l'efs, |. Les-médicaments-de-thérapie-innovante, and . Mti, , 2019.

, « Code de la santé publique -Article L1221-8 | Legifrance, 2020.

«. Conseil-d'état, , vol.375056, 2020.

. Règlement, 1394/2007 du Parlement européen et du Conseil du 13 novembre 2007 concernant les médicaments de thérapie innovante et modifiant la directive 2001/83/CE ainsi que le règlement (CE), vol.726, 2004.

, mins-Features, « Why Are There Only 10 Cell and Gene Therapies in Europe?, 2018.

, -302 du 22 mars 2011 portant diverses dispositions d'adaptation de la législation au droit de l'Union européenne en matière de santé, de travail et de communications électroniques, 2011.

, Code de la santé publique -Article L5121-1, pp.5121-5122

N. Ferry, M. Qu'est-ce-qu'un, U. Mti-pp, and U. Ptc?-», , p.24

D. Sur,

, Code de la santé publique -Article L1245-2, pp.1245-1247

D. M. Dohan-ehrenfest, L. Rasmusson, and T. Albrektsson, Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte-and platelet-rich fibrin (L-PRF), vol.27, pp.158-167, 2009.

G. M. Van-buul, Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic Chondrocytes, 2011.

A. Fotouhi, A. Maleki, S. Dolati, and A. Aghebati-maleki, Aghebati-Maleki, « Platelet rich plasma, stromal vascular fraction and autologous conditioned serum in treatment of knee osteoarthritis », Biomed. Pharmacother, vol.104, pp.652-660, 2018.

«. Plasma, At the Dawn of an Off-the-Shelf Therapy? -PubMed -NCBI, vol.10, 2020.

H. Meijer, J. Reinecke, C. Becker, G. Tholen, and P. Wehling, « The production of anti-inflammatory cytokines in whole blood by physico-chemical induction », Inflamm. Res, vol.52, issue.10, pp.404-407, 2003.

M. M. Richards, J. S. Maxwell, L. Weng, M. G. Angelos, and J. Golzarian, « Intra-articular Treatment of Knee Osteoarthritis: from Anti-inflammatories to Products of Regenerative Medicine, Phys. Sportsmed, vol.44, issue.2, pp.101-108, 2016.

A. Frizziero, E. Giannotti, F. Oliva, S. Masiero, and N. Maffulli, « Autologous conditioned serum for the treatment of osteoarthritis and other possible applications in musculoskeletal disorders », Br. Med. Bull, vol.105, pp.169-184, 2013.

D. B. Carter, « Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein, Nature, vol.344, pp.633-638

C. H. Hannum, « Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor, Nature, vol.343, pp.336-340

J. M. Cassano, J. G. Kennedy, K. A. Ross, E. J. Fraser, M. B. Goodale et al., « Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration, Knee Surg. Sports Traumatol. Arthrosc. Off. J. ESSKA, vol.26, issue.1, pp.333-342, 2018.

J. Holton, M. Imam, J. Ward, and M. Snow, « The Basic Science of Bone Marrow Aspirate Concentrate in Chondral Injuries », Orthop. Rev, vol.8, issue.3, p.6659, 2016.

L. A. Fortier, J. U. Barker, E. J. Strauss, T. M. Mccarrel, and B. J. Cole, « The role of growth factors in cartilage repair, Clin. Orthop, vol.469, issue.10, pp.2706-2715, 2011.

K. Miyazawa, M. Shinozaki, T. Hara, T. Furuya, and K. Miyazono, « Two major Smad pathways in TGF-beta superfamily signalling, Genes Cells Devoted Mol. Cell. Mech, vol.7, pp.1191-1204

T. Squillaro, G. Peluso, and U. Galderisi, Clinical Trials With Mesenchymal Stem Cells: An Update, vol.25, issue.5, pp.829-848, 2016.

«. Micro, Fractured and Purified Adipose Tissue Graft (Lipogems®) Can Improve the Orthognathic Surgery Outcomes Both Aesthetically and in Postoperative Healing -CellR4, 2020.

Z. Alharbi, C. Opländer, S. Almakadi, A. Fritz, M. Vogt et al., « Conventional vs. micro-fat harvesting: How fat harvesting technique affects tissue-engineering approaches using adipose tissue-derived stem/stromal cells, J. Plast. Reconstr. Aesthet. Surg, vol.66, issue.9, pp.1271-1278

F. Bembo, « Combined use of platelet rich plasma & micro-fat in sport and race horses with degenerative joint disease: preliminary clinical study in eight horses, p.7

A. Mayoly, « Development of Autologous Platelet-Rich Plasma Mixed-Microfat as an Advanced Therapy Medicinal Product for Intra-Articular Injection of Radio-Carpal Osteoarthritis: From Validation Data to Preliminary Clinical Results », Int. J. Mol. Sci, vol.20, issue.5, p.2019

F. Bembo, « Combined use of platelet rich plasma & micro-fat in sport and race horses with degenerative joint disease: preliminary clinical study in eight horses, Muscles Ligaments Tendons J, vol.6, issue.2, pp.198-204

M. Rodbell and A. B. Jones, « Metabolism of isolated fat cells. 3. The similar inhibitory action of phospholipase C (Clostridium perfringens alpha toxin) and of insulin on lipolysis stimulated by lipolytic hormones and theophylline, J. Biol. Chem, vol.241, issue.1, pp.140-142, 1966.

J. M. Gimble, A. J. Katz, and B. A. Bunnell, « Adipose-derived stem cells for regenerative medicine », Circ. Res, vol.100, issue.9, pp.1249-1260, 2007.

J. Rehman, « Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells, Circulation, vol.109, issue.10, pp.1292-1298, 2004.

S. Gronthos, D. M. Franklin, H. A. Leddy, P. G. Robey, R. W. Storms et al., « Surface protein characterization of human adipose tissue-derived stromal cells, J. Cell. Physiol, vol.189, issue.1, pp.54-63, 2001.

M. Dominici, « Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement, Cytotherapy, vol.8, issue.4, pp.315-317, 2006.

Y. A. Romanov, V. A. Svintsitskaya, and V. N. Smirnov, « Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord, Stem Cells Dayt. Ohio, vol.21, issue.1, pp.105-110, 2003.

Y. Fukuchi, H. Nakajima, D. Sugiyama, I. Hirose, T. Kitamura et al., « Human placentaderived cells have mesenchymal stem/progenitor cell potential, Stem Cells Dayt. Ohio, vol.22, issue.5, pp.649-658, 2004.

C. Bari, F. Dell'accio, P. Tylzanowski, and F. P. Luyten, « Multipotent mesenchymal stem cells from adult human synovial membrane, Arthritis Rheum, vol.44, issue.8, 1928.

D. , « Cell specific differences between human adipose-derived and mesenchymalstromal cells despite similar differentiation potentials, Exp. Cell Res, vol.314, issue.7, pp.1575-1584, 2008.

M. Maumus, Y. Pers, M. Ruiz, C. Jorgensen, and E. D. Noël, Cellules souches mésenchymateuses et médecine régénératrice -Quel avenir pour l'arthrose ? », médecine/sciences, vol.34, pp.1092-1099, 2018.

B. A. Tompkins, « Preclinical Studies of Stem Cell Therapy for Heart Disease », Circ. Res, vol.122, issue.7, pp.1006-1020, 2018.

P. A. Zuk, « Multilineage cells from human adipose tissue: implications for cell-based therapies, Tissue Eng, vol.7, issue.2, pp.211-228, 2001.

P. Palumbo, F. Lombardi, G. Siragusa, M. Cifone, B. Cinque et al., « Methods of Isolation, Characterization and Expansion of Human Adipose-Derived Stem Cells (ASCs): An Overview », Int. J. Mol. Sci, vol.19, issue.7, p.1897, 2018.

C. Dosquet and M. Moreau, Cellules souches mésenchymateuses et immunomodulation : intérêt en thérapie cellulaire et risques potentiels », vol.14, p.5, 2008.

J. A. Ankrum, J. F. Ong, and J. M. Karp, « Mesenchymal stem cells: immune evasive, not immune privileged, Nat. Biotechnol, vol.32, issue.3, p.252, 2014.

S. , « Human mesenchymal stem cells modulate allogeneic immune cell responses, Blood, vol.105, pp.1815-1822, 2005.

M. D. Griffin, A. E. Ryan, S. Alagesan, P. Lohan, O. Treacy et al., « Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far? », Immunol, Cell Biol, vol.91, issue.1, pp.40-51

N. D. Vitale, « Innovative regenerative medicine in the management of knee OA: The role of Autologous Protein Solution, J. Clin. Orthop. Trauma, vol.10, issue.1, pp.49-52

K. M. O'shaughnessey, A. Panitch, and J. E. , Woodell-May, « Blood-derived anti-inflammatory protein solution blocks the effect of IL-1? on human macrophages in vitro », Inflamm. Res, vol.60, issue.10, p.929, 2011.

A. Matuska, K. O'shaughnessey, and W. King, Woodell-May, « Autologous solution protects bovine cartilage explants from IL-1?-and TNF?-induced cartilage degradation, J. Orthop. Res, vol.31, pp.1929-1935, 2013.

A. L. Bertone, « Evaluation of a single intra-articular injection of autologous protein solution for treatment of osteoarthritis in horses, Am. J. Vet. Res, vol.75, issue.2, pp.141-151, 2014.

W. King, W. Van-der-weegen, R. Van-drumpt, H. Soons, and K. Toler, Woodell-May, « White blood cell concentration correlates with increased concentrations of IL-1ra and improvement in WOMAC pain scores in an open-label safety study of autologous protein solution, J. Exp. Orthop, vol.3, issue.1, p.9, 2016.

K. A. Kimmerling, A. H. Gomoll, J. Farr, and K. C. Mowry, Amniotic Suspension Allograft Modulates Inflammation in a Rat Pain Model of Osteoarthritis, J. Orthop. Res

C. Hannon, A. Yanke, and J. Farr, « Amniotic Tissue Modulation of Knee Pain-A Focus on Osteoarthritis, J. Knee Surg, vol.32, pp.26-036

«. Organogenesis, ReNu -Product Information, 2020.

W. Dai, A. Zhou, H. Zhang, and J. Zhang, « Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials, Arthrosc. J. Arthrosc. Relat. Surg, vol.33, issue.3, p.2017

E. Vinod, D. Francis, S. Manickam-amirtham, S. Sathishkumar, and P. R. Boopalan, Allogeneic platelet rich plasma serves as a scaffold for articular cartilage derived chondroprogenitors, Tissue Cell, vol.56, pp.107-113

L. Camargo-garbin, C. W. Mcilwraith, and D. D. Frisbie, « Evaluation of allogeneic freeze-dried platelet lysate in cartilage exposed to interleukin 1-? in vitro, BMC Vet. Res, vol.15, issue.1, p.386, 2019.

C. Beerts, « Tenogenically Induced Allogeneic Peripheral Blood Mesenchymal Stem Cells in Allogeneic Platelet-Rich Plasma: 2-Year Follow-up after Tendon or Ligament Treatment in Horses, Front. Vet. Sci, vol.4, p.158, 2017.

X. Liao, « Allogeneic Platelet-Rich Plasma Therapy as an Effective and Safe Adjuvant Method for Chronic Wounds, J. Surg. Res, vol.246, pp.284-291, 2020.

C. H. Jo, S. Y. Lee, K. S. Yoon, S. Oh, and E. S. Shin, Allogenic Pure Platelet-Rich Plasma Therapy for Rotator Cuff Disease: A Bench and Bed Study, vol.46, pp.3142-3154, 2018.

A. W. Baltzer, C. Moser, S. A. Jansen, and R. Krauspe, « Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis, Osteoarthritis Cartilage, vol.17, issue.2, pp.152-160, 2009.

S. A. Shapiro, S. E. Kazmerchak, M. G. Heckman, A. C. Zubair, M. I. O'connor et al., Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis », Am. J. Sports Med, vol.45, issue.1, pp.82-90, 2017.

J. R. Garza, « Clinical Efficacy of Intra-articular Mesenchymal Stromal Cells for the Treatment of Knee Osteoarthritis: A Double-Blinded Prospective Randomized Controlled Clinical Trial », Am. J. Sports Med, vol.48, issue.3, pp.588-598

Y. Pers, Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial: ASCs for Severe OA of the Knee », STEM CELLS Transl. Med, vol.5, issue.7, pp.847-856, 2016.

W. Lee, H. J. Kim, K. Kim, G. B. Kim, and E. W. Jin, « Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial, Stem Cells Transl. Med, vol.8, issue.6, pp.504-511, 2019.

E. Kon, L. Engebretsen, P. Verdonk, S. Nehrer, and G. Filardo, « Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial », Am. J. Sports Med, vol.46, issue.1, pp.171-180, 2018.

J. Farr, A. H. Gomoll, A. B. Yanke, E. J. Strauss, K. C. Mowry et al., « A Randomized Controlled Single-Blind Study Demonstrating Superiority of Amniotic Suspension Allograft Injection Over Hyaluronic Acid and Saline Control for Modification of Knee Osteoarthritis Symptoms, J. Knee Surg, vol.32, issue.11, pp.1143-1154, 2019.

A. Golchin, F. Shams, P. Kangari, A. Azari, and E. S. Hosseinzadeh, Regenerative Medicine: Injectable Cell-Based Therapeutics and Approved Products, vol.7, pp.75-95, 2019.

R. Crowe, C. Willers, T. Cheng, L. Wang, and M. Zheng, « Evaluation of Intraoperative Retention of Autologous Chondrocytes on Type I/III Collagen Scaffold (Ortho-ACI TM ) for Cartilage Repair, J. Foot Ankle Res, vol.8, issue.S2, p.10, 1146.

J. R. Ebert, M. Fallon, M. H. Zheng, and A. Tay, « Arthroscopic autologous chondrocyte implantation in the glenohumeral joint: a case report, J. Shoulder Elbow Surg, vol.27, issue.10, pp.300-307, 2018.

P. Niemeyer, Phase III Noninferiority Trial to Compare the Clinical Efficacy of Matrix-Associated Autologous Chondrocyte Implantation With Spheroid Technology Versus Arthroscopic Microfracture for Cartilage Defects of the Knee », Orthop. J. Sports Med, vol.7, issue.7, p.232596711985444

J. Song, « Implantation of allogenic umbilical cord blood-derived mesenchymal stem cells improves knee osteoarthritis outcomes: Two-year follow-up, Regen. Ther, vol.14, pp.32-39

N. Choi, « Gel-type autologous chondrocyte (Chondron TM ) implantation for treatment of articular cartilage defects of the knee, BMC Musculoskelet. Disord, vol.11, issue.1, p.103

T. Negoro, Y. Takagaki, H. Okura, and E. A. Matsuyama, « Trends in clinical trials for articular cartilage repair by cell therapy, NPJ Regen. Med, vol.3, 2018.

D. Saris, « Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Two-Year Follow-up of a Prospective Randomized Trial », Am. J. Sports Med, vol.42, issue.6, pp.1384-1394, 2014.

G. F. Giordano, « Autologous platelet-rich plasma in cardiac surgery: effect on intraoperative and postoperative transfusion requirements, Ann. Thorac. Surg, vol.46, issue.4, pp.64655-64658, 1988.

P. Bertin, « Annual Cost of Patients with Osteoarthritis of the Hip and Knee in France, J. Musculoskelet. Pain, vol.22, issue.4, pp.356-364

S. Landi, P. Landa, and E. S. Russo, « Knee OA management: A cost-effectiveness analysis of platelet-rich-plasma versus hyaluronic acid for the intra-articular treatment of knee OA in France », Int. J. Clin. Rheumatol, 2018.

«. Ortho, -. , and O. , , 2020.