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Master Thesis

Eczémas de contact aux capteurs de glycémie chez les patients diabétiques (EXODIA)

Abstract : Background: Blood glucose sensors are innovative medical devices that ensure a better glycemic control without the disadvantages of the classic finger prick measure. However, contact dermatitis represents the main side effect of these devices, and although the reported cases are on the increase, no study has looked at the allergic or irritant nature of these skin lesions regardless of their severity. Objectives: To establish the proportion of patients with allergic contact dermatitis (ACD) or irritant contact dermatitis (ICD) in a population of diabetic patients using a blood glucose sensor, compare the main characteristics of these two populations and look for possible cross-sensitizations. Patients and Methods: Were included diabetic patients using a blood glucose sensor and presenting recurrent skin symptomatology under their device. All were patch tested with a baseline series, an acrylate and methacrylates series, isobornyl acrylate (IBOA) 0.1% pet., and a patch test with a fragment of adhesive from the culprit sensor. A patient was identified as allergic if he reacted positively to the adhesive of the glycemic sensor and/or to a substance that is known to be contained in the said sensor. The diagnosis of irritant dermatitis was made if the patient did not meet any of these conditions. Results: Thirty-four patients meeting the inclusion criteria were seen in the allergology department. 19 patients presented with allergic contact dermatitis (55.9%) and 15 patients presented with probable irritant contact dermatitis (44.1%). In the allergic population, 16 were to IBOA and 3 were to colophony. Sesquiterpene lactone (SL) positivity was demonstrated in 43.8% of IBOA positive patients. The impact on quality of life was greater in patients with allergic contact dermatitis. No difference was found between these two groups regarding atopy, nor on their becoming. Conclusion: Our study made it possible to demonstrate in a population of diabetic patients presenting contact dermatitis to their glycemic sensor that the majority of them were allergic to it and with a markedly impaired quality of life, which underlines the benefit of the diagnostic management of these patients in the allergy department. The high rate of co-sensitization between IBOA and SL still remains to be explained.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02982516
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Submitted on : Wednesday, October 28, 2020 - 4:11:04 PM
Last modification on : Tuesday, November 24, 2020 - 4:00:15 PM

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Kabil Nakara. Eczémas de contact aux capteurs de glycémie chez les patients diabétiques (EXODIA). Médecine humaine et pathologie. 2020. ⟨dumas-02982516⟩

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