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Master Thesis

IIU versus FIV : le choix de la dose ?

Abstract : Introduction: In France, 10% of the couples are infertile and they can benefit from the medically assisted reproduction in order to procreate. According to the biomedicine agency, in 2016, such medical assistance provided positive results for 22% of the IVF-ICSI, 20% of the conventional IVF, 14% of the fresh embryo transfers and 10% of the IUI. Multiple attempts that can be necessary for the obtention of a viable embryo are a source of stress and often generate feelings of failure for couples. This is why the medical team has the desire to decrease the number of attempts. The main purpose of our study is to compare the initial prescribed dose of gonadotrophins for a first attempt at IVF (TA IVF), for an identical estimated ovarian reserve, between naive patients an those who previously had three IUI. Materials and methods: we conducted a quantitative, retrospective, non-interventional, mono-centric cohort study with two parallel groups. Patients were followed from October 2017 to October 2018 with AMP 13005 IMR-Alphabio-Bouchard. We studied all the maternal initial characteristics, the stimulation protocol, the punctured oocytes, embryos obtained and rates of alive pregnancies and births. Our aim is to determine whether making an IUI prior to an IVF has an influence on the conduct and outcome of the IVF. Results: we studied 2 homogeneous groups of 96 patients. The results showed that there is no significant difference in the type of protocol used (p=0.029) between the group that primarily received IUI versus the group that directly received IVF. Initial and total gonadotrophin doses used for ovarian stimulation are not significantly different between both groups. The rates of alive births and pregnancies are significantly higher for the group that previously had IUI (p= 0.095 and p=0.073). Conclusion: making an IUI prior to an IVF has an impact on the conduct of the IVF. This influence does not appear to come from the doses of gonadotrophins used in ovarian pacing. Other parameters that we could not study here, should be explored to explain this difference.
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https://dumas.ccsd.cnrs.fr/dumas-02988207
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  • HAL Id : dumas-02988207, version 1

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Marine Cornille. IIU versus FIV : le choix de la dose ?. Gynécologie et obstétrique. 2020. ⟨dumas-02988207⟩

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