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Master Thesis

Infections sexuellement transmissibles : épidémiologie des anorectites dans une cohorte prospective en 2018

Abstract : Sexual transmitted infections (STIs) have a profound impact on health worldwide. Each year, there are an estimated 357 million new sexual infections. Men who have sex with men (MSM) have been identified as a high rate population. The proctology center of Saint-Joseph hospital in Paris, specialized in proctitis, is especially confronted with the diagnosis of STIs. The primary objective of this study is a description of anorectal infection bacteriological epidemiology in our observational prospective cohort. The secondary objective is to compare performance of nucleic acid amplification tests (NAAT) GeneXpert® and Allplex® in these infections. Three hundred and eleven patients with proctitis were included from 1st February 2018 to 1st March 2019. Rectal swab searching Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) by Cepheid PCR was performed. Finally, 78% of our patients were MSM, 60% declared having previous STIs history with NG or CT and 17% were infected by HIV. A multiplex PCR was performed for 194 patients. Forty-one patients were NG positives, 73 were CT positives including 60 for serovar L, 77 for mycoplasmas, 30 for herpes and 9 for Treponema pallidum. Both NAAT have same performance: concordance for NG is 100% and 98% for CT. We were not able to correlate clinical signs with a pathogen in our collection of clinicals data.
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Master Thesis
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Contributor : Université Paris Descartes - Scd <>
Submitted on : Monday, November 9, 2020 - 5:44:01 PM
Last modification on : Thursday, February 18, 2021 - 3:21:03 AM


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  • HAL Id : dumas-02996761, version 1


Louis Mine. Infections sexuellement transmissibles : épidémiologie des anorectites dans une cohorte prospective en 2018. Médecine humaine et pathologie. 2019. ⟨dumas-02996761⟩



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