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Master Thesis

Association entre les traitements par inhibiteurs de la pompe à protons et la survenue des gastro-entérites en période épidémique hivernale, étude de cohorte, France, 2015-2016

Abstract : Background: recent studies suggest that proton pump inhibitors (PPIs) are associated with infectious adverse effects. We studied the potential association between chronic consumption of PPIs and the occurrence of viral acute gastroenteritis (AG) during a winter epidemic. Methods: this is an exposed-unexposed cohort study, conducted from a drug database, comprising about one-third of the French population during the 2015-2016 winter season. The presentations were subjects consuming a PPI while the unexposed did not receive any PPIs. The primary outcome was the occurrence of a AG during the epidemic period, identified by a validated algorithm. Relative risks were estimated using a log binomial regression model adjusted by age, sex, reference pharmacy and co-morbidity. Results: the occurrence of AG was significantly associated with chronic consumption of PPIs, with an RR adjusted to 1.90 (95% CI [1.83; 1.98]). Sensitivity analyses with 2016-2017 season data and patients who had used PPIs for less than 6 months showed the same trend with RR adjusted to 1.78 [1.71; 1.84] and 1.60 [1.43; 1.79] respectively. Conclusion: there is an increased risk of AG in patients who are consuming PPIs chronically. Nevertheless further studies are needed before confirming a causal association.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02996827
Contributor : Université Paris Descartes - Scd <>
Submitted on : Monday, November 9, 2020 - 6:16:35 PM
Last modification on : Thursday, February 18, 2021 - 3:21:03 AM

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  • HAL Id : dumas-02996827, version 1

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Laure Sabatte. Association entre les traitements par inhibiteurs de la pompe à protons et la survenue des gastro-entérites en période épidémique hivernale, étude de cohorte, France, 2015-2016. Médecine humaine et pathologie. 2019. ⟨dumas-02996827⟩

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