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Master Thesis

Réduction majeure d'HbA1c et rétinopathie dans le diabète de type 2

Abstract : Aims: does Diabetic Retinopathy (DR) relate to a previous dramatic reduction of HbA1c in Type 2 Diabetes (T2D)? Methods: in patients hospitalized for T2D, we collected HbA1c values from previous years, and we defined “Rapid declinors” by a more than −3% reduction between two consecutive HbA1c, and “sustained moderate declinors” by HbA1c declining less than −3%. We analyzed the relation between DR and previous HbA1c courses, adjusted for other risk factors. Results: our 680 patients had a mean HbA1c of 8.7 ± 1.7% at admission and 8.7 ± 1.8 to 9.0 ± 2.2% during previous years (1500 HbA1C values collected), and 24% had a DR. A previous rapid decline of HbA1c occurred in 13.5% of subjects and related to DR (OR = 1.86, 95%CI : 1.02–3.40), especially proliferative (OR = 2.64, 95%CI : 1.02–6.80), after adjustment for age, gender, body mass index, arterial hypertension and diabetic kidney disease, blood lipids and statin treatment, duration of diabetes and mean previous HbA1c. A previous moderate reduction of HbA1c, as occurred in 28.3% other subjects, was not related to DR. Conclusions: in subjects hospitalized for T2D, a previous rapid decline of HbA1c was related to proliferative DR, whereas a sustained moderate decline appeared to be safe.
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https://dumas.ccsd.cnrs.fr/dumas-03008066
Contributor : Médecine Ub <>
Submitted on : Monday, November 16, 2020 - 4:12:22 PM
Last modification on : Saturday, December 19, 2020 - 3:12:50 AM

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Alice Larroumet. Réduction majeure d'HbA1c et rétinopathie dans le diabète de type 2. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03008066⟩

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