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Master Thesis

Atrophie des sous-champs hippocampiques en lien avec l'atteinte vasculaire

Abstract : Background and Purpose: many neurological or psychiatric diseases affect the hippocampus during aging. The study of hippocampal regional vulnerability may provide important insights into the pathophysiological mechanisms underlying these processes; however, little is known about the specific impact of vascular brain damage on hippocampal subfields atrophy. Methods: to study the “pure” effect of vascular injuries independently of other pathological conditions, we investigated 249 participants from a population-based cohort of non-demented older adults, after the exclusion of all people who were diagnosed with neurodegenerative diseases during the 14-year clinical follow-up period. Using an automated segmentation pipeline, MRI at inclusion and 4 years later were assessed to measure both white matter hyperintensities (WMH) and hippocampal subfields volume. Annualized rates of WMH progression and annualized rates of hippocampal subfields atrophy were then estimated in each participant. Results: the volume of the subiculum at baseline was the only hippocampal subfield volume associated with total, deep/subcortical and periventricular WMH volumes, independently of demographic variables and vascular risk factors (ß= -0.17, p=0.011; ß= -0.25, p=0.020 and ß= -0.14, p=0.029 respectively). In longitudinal measures, the annualized rate of subiculum atrophy was significantly higher in people with the highest rate of deep/subcortical WMH progression, independently of confounding factors (ß= -0.32, p=0.014). Conclusions: these cross-sectional and longitudinal findings highlight the differential vulnerability of the subiculum to vascular brain injuries within the hippocampal loop, unbiased of the effect of neurodegenerative diseases, and particularly when it affects deep/subcortical structures.
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Contributor : Médecine Ub <>
Submitted on : Wednesday, November 18, 2020 - 10:31:56 AM
Last modification on : Saturday, December 19, 2020 - 3:12:50 AM
Long-term archiving on: : Friday, February 19, 2021 - 6:51:06 PM


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  • HAL Id : dumas-03011513, version 1



Grégoire Pin. Atrophie des sous-champs hippocampiques en lien avec l'atteinte vasculaire. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03011513⟩



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