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Master Thesis

Utilisation de statines et maladie veineuse thrombo-embolique : une étude cas-contrôle chez des patients âgés de 75 ans et plus

Abstract : Introduction: although previous studies reported a lower rate of venous thrombo-embolism in statin users, such studies were conducted in selected patients and results may not be generalizable to an old and multimorbid population. The aim of this study was to investigate the influence of statin use on the risk of venous thromboembolic events (VTE) in elderly patients. Methods: we used a retrospective case-control study of patients aged 75 and older, hospitalized in Bordeaux University Hospital from 2009 to 2019. 177 cases with a documented episode of VTE were included, matched with 177 controls on age, gender, and year of hospitalization. Patients under long-term anticoagulation before admission were excluded. Results: over 177 cases, 31 (17,5%) reported statin use at the admission, as well as 36 (20,3%) controls. Statin use was not associated with a decreased risk of VTE in this study (OR 0,8 CI 95% [0,5-1,4], p=0,5). Adjustment for age, sex, atherosclerotic diseases, major risk factors for VTE and use of antiplatelet therapy did not alter the result. Neither aspirin (OR 1 CI95% 0,6-1,6], p = 1) nor other antiplatelet therapies (OR 0,6 CI95% [0,3-1,3], p=0,2) were associated with a reduced risk of VTE. Compared to non-users, statin users had significantly more comorbidities such as atherosclerotic diseases, hypertension and diabetes. In conclusion, this study does not support a protective effect of statins on VTE risk in elderly and multimorbid patients.
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https://dumas.ccsd.cnrs.fr/dumas-03014240
Contributor : Médecine Ub <>
Submitted on : Thursday, November 19, 2020 - 12:33:08 PM
Last modification on : Thursday, January 21, 2021 - 3:10:31 AM
Long-term archiving on: : Saturday, February 20, 2021 - 7:11:02 PM

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  • HAL Id : dumas-03014240, version 1

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Lisa Guénard. Utilisation de statines et maladie veineuse thrombo-embolique : une étude cas-contrôle chez des patients âgés de 75 ans et plus. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03014240⟩

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