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Master Thesis

Prescriptions pédiatriques inadaptées à l’officine : étude observationnelle dans l’arc alpin

Abstract : Drug-related iatrogenesis can lead to adverse events with clinical consequences. It particularly concerns vulnerable populations at extreme ages like children and elderly people. Many studies were performed on potentially inappropriate drugs in geriatrics. However, there is a lack of paediatric studies. ALPPIN study aimed to evaluate the quality of paediatric outpatients’ prescriptions. Drug prescriptions for patients aged from 0 to 18 years old were collected at the community pharmacies of the Arc Alpin (France), during two phases (in February and May 2019). A pharmaceutical analysis was carried out with the classification of the French Society of Clinical Pharmacy and the POPI guide (Paediatrics: Omission and Inappropriate Prescription), a specific tool for paediatric population. Prescriptions were considered inadequate when at least one drug were inappropriate or omitted. A total of 560 prescriptions were collected during study. 41,8% of prescriptions had at least an inappropriate drug. The most common problem was a contraindication or a noncompliance with guidelines (84,9%). The most misused prescription concerned amoxicillin in ENT infections (14,0%). Drug substitution was the most frequent pharmaceutical intervention to be performed (37,0%). This study shows the high prevalence of paediatric outpatients’ inadequate prescriptions. Training of health professionals is essential to secure and optimize practices around drugs in paediatrics.
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Master Thesis
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Submitted on : Monday, November 23, 2020 - 10:36:09 AM
Last modification on : Wednesday, November 25, 2020 - 3:24:35 AM
Long-term archiving on: : Wednesday, February 24, 2021 - 6:42:54 PM


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  • HAL Id : dumas-03018942, version 1


Mathilde Frasson-Peiguet. Prescriptions pédiatriques inadaptées à l’officine : étude observationnelle dans l’arc alpin. Sciences pharmaceutiques. 2019. ⟨dumas-03018942⟩



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