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Master Thesis

Ostéoimmunologie des parodontites

Abstract : Osteoimmunology studies the molecular and cellular mechanisms involved in the dialogue between the immune system and the skeletal system. The hallmark sign of periodontitis is the destruction of the alveolar bone that results from an imbalance in bone turnover cycles. Despite their initially protective role, immune cells that accumulate in the gum tissue during periodontitis activate the resorption of adjacent alveolar bone. Many players in innate immunity and adaptive immunity release pro-inflammatory cytokines that influence the RANK-RANKL-OPG axis, the main regulator of osteoclast activity. Innate immunity provides immediate defense against periodontopathic pathogens, but neutrophils, macrophages, mast cells, complement, NK cells and dendritic cells activate osteoclasts. Adaptive immunity provides a specific and effective defense against periodontopathic pathogens, but plasma cells and various polarized T cells also greatly contribute to the activation of osteoclasts. The immune regulatory mechanisms underlying periodontitis are complex and remain to be precisely determined. Their knowledge would allow the development of new therapies focused on modulating the host's response.
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Master Thesis
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Contributor : Bibliothèque Universitaire de Médecine Nice Connect in order to contact the contributor
Submitted on : Tuesday, December 15, 2020 - 3:54:06 PM
Last modification on : Wednesday, May 5, 2021 - 3:16:01 AM


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  • HAL Id : dumas-03068266, version 1


Ludmilla Vakili. Ostéoimmunologie des parodontites. Médecine humaine et pathologie. 2020. ⟨dumas-03068266⟩



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