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Master Thesis

Paralysie périodique familiale hypokaliémique associée à une hypertension : hypothèses mécanistiques à propos d’un cas

Abstract : Hypokalemic Familial Periodic Paralysis is a rare genetic disease belonging to the group of skeletal muscle channelopathy, causing flaccid paralysis due to different genetic mutations of ion channels. We report the case of a young subject suffering from this neuro-muscular pathology, which was associated with hypertension suggesting an unusual form of primary hyperaldosteronism. Although the investigations carried out have not formally confirmed the link between hypokalemic periodic paralysis and this atypical hypertension, a causal relation between these two conditions is evoked and the mechanisms potentially involved are discussed. This case reminds us of the importance of a rigorous diagnostic and etiological approach when faced with common situations such as hypokalemia or hypertension, situations that may reveal rare pathologies requiring a relevant orientation.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03130451
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Submitted on : Wednesday, February 3, 2021 - 3:41:45 PM
Last modification on : Tuesday, October 19, 2021 - 11:34:51 PM

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  • HAL Id : dumas-03130451, version 1

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Angélique Le Métayer. Paralysie périodique familiale hypokaliémique associée à une hypertension : hypothèses mécanistiques à propos d’un cas. Médecine humaine et pathologie. 2020. ⟨dumas-03130451⟩

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