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Master Thesis

Porphyromonas gingivalis, porte d’entrée vers la maladie d’Alzheimer ?

Abstract : Alzheimer’s disease is the leading cause of dementia in the world and a major public health issue of the 21st century. Its progressive appearance disrupts memory, cognitive functions and leads to loss of autonomy in affected patients. The main components are the appearance of amyloïd plaques, hyper-phosphorylation of Tau proteins, neuro-inflammation and increased oxidative stress. However, it is estimated that one-third of the world’s cases of Alzheimer’s disease could be attributed to potentially modifiable risk factors. We will study a possible bacterial etiology related to an oral infection in the development of the disease by focusing on a particular bacterium, Porphyromonas gingivalis.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03136377
Contributor : Frédérique Gambade <>
Submitted on : Tuesday, February 9, 2021 - 4:30:41 PM
Last modification on : Saturday, February 13, 2021 - 3:10:00 AM
Long-term archiving on: : Monday, May 10, 2021 - 7:01:49 PM

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Pharmacie_2021_Denis.pdf
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  • HAL Id : dumas-03136377, version 1

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Thomas Denis. Porphyromonas gingivalis, porte d’entrée vers la maladie d’Alzheimer ?. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03136377⟩

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