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Master Thesis

Can 18F-FDG PET/CT findings be used to predict orbital tumor histology?

Abstract : Purpose: to investigate whether 18F-FDG PET/CT could be useful to predict the histology of various orbital tumors based on the maximum Standard Uptake Value (SUVmax) and the OMSUV (Orbital Max SUV)/MLSUV (Mean Liver SUV) ratio.
Methods: a retrospective monocentric study was conducted between May 2019 and December 2020. Patients with an orbital mass who underwent preoperative 18F-FDG PET/CT followed by an orbital biopsy were included. Tumor histology was classified as follows: orbital inflammation, solid tumor, low-grade lymphoid tumor, and high-grade lymphoid tumor. Orbital tumors were also classified as indolent or aggressive. Data recorded included the orbital SUVmax, OMSUV/MLSUV ratio and additional extra-orbital SUV sites.
Results: forty-five patients (24 men) were included. There were 15 (33.3%), 14 (31.1%), 9 (20%), and 7 (15.5%) cases of orbital inflammation, solid tumor, low-grade lymphoid tumor, and high-grade lymphoid tumor, respectively. No correlation was found between the OMSUV/MLSUV ratio and orbital SUVmax and the tumor histology (Z= -0.77, Z= -0.6, Z= -1.6, and Z= 0.94, all p >0.05, respectively). No correlation was found between the OMSUV/MLSUV ratio (Z= -1.42, P >0.05) and orbital SUVmax (Z= -0.82, P >0.05) and the tumor aggressiveness (indolent versus aggressive). Subgroup analyzes showed that the SUVmax was almost predictive of lymphoma aggressiveness (p=0.05) and allowed distinguishing orbital cancers (High-grade lymphomas + solid tumors) from indolent tumors (Low-grade lymphomas + benign tumors).
Conclusion: 18F-FDG PET/CT could not be used to predict the underlying orbital tumor histology. However, more aggressive tumors, especially high-grade lymphomas and cancers, tended to have a higher orbital SUVmax compared to indolent lesions.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03201907
Contributor : Bibliothèque Universitaire de Médecine Nice Connect in order to contact the contributor
Submitted on : Monday, April 19, 2021 - 1:44:35 PM
Last modification on : Saturday, October 16, 2021 - 3:23:54 AM

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  • HAL Id : dumas-03201907, version 1

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Barbara Monjanel. Can 18F-FDG PET/CT findings be used to predict orbital tumor histology?. Human health and pathology. 2021. ⟨dumas-03201907⟩

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