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Master Thesis

Physiopathologie des psychoses épileptiques

Abstract : Epilepsy is a chronic disease that affects around 50 million people worldwide, and is a cause of a significant morbidity and mortality. Despite the effectiveness of current antiepileptic drugs, drug resistance occurs in 30% of the patients. Psychotic disorders are more common in patients with resistant epilepsy. Thus, these patients have a 5.5 times higher risk of developing epileptic psychosis and a 8.5 times increased risk of having for schizophrenia. Despite the abundance of scientific publications devoted to epileptic psychoses and their complex clinical aspects, their physiopathology remains partially known. This enigma constitutes the field of investigation of this thesis. First, we will approach the historical and clinical aspects of epileptic psychosis. We can thus differentiate: ictal and peri-ictal psychoses, inter-ictal psychoses and post-ictal psychoses. In a second step, we will develop the physiopathology bases by linking epilepsy and psychosis. On the one hand, while the cerebral structure is at the core of mental disorders, it is indeed essential to decipher the causes of its alteration: genetic, environmental or critical. On the other hand, the existence of an aberrant neuronal discharge develops its own psychic symptomatology, depending on the affected brain region. Thus, there is an influence of the critical episode on the psychotic manifestation. Throughout history, and until recently, physiopathology hypotheses of epileptic psychoses have been proposed. Each brings a specific vision regarding the genesis and the links between these two disorders: i) alternations, ii) cause and effect, or iii) having an underlying common cause. In order, this work crosses the present hypotheses while gathering the latest physiological discoveries that may influence epileptic psychoses.
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Submitted on : Thursday, April 22, 2021 - 11:58:27 AM
Last modification on : Wednesday, November 3, 2021 - 7:21:47 AM


  • HAL Id : dumas-03205398, version 1


Agustina Longobardi. Physiopathologie des psychoses épileptiques. Médecine humaine et pathologie. 2020. ⟨dumas-03205398⟩



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