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Master Thesis

Conventional chemotherapy for AML in older adults: impact on nutritional, cognitive and functional status

Abstract : Background: We assessed the impact of conventional treatment for acute myeloid leukemia (AML) on the nutritional, cognitive, and functional status of patients over 60 with a new diagnosis of AML treated using the LAM-SA 2007 FILO trial protocol. Patients and methods: 424 patients with de novo AML diagnosis without adverse cytogenetic criteria and an Eastern Cooperative Oncology Group score ≤ 2 were included between February 2008 and December 2011. Three geriatric assessment (GA) domains were used for evaluation: nutritional status using the Mini Nutritional Assessment, cognitive status by the Mini Mental State Examination, and functional status by activity of daily living (ADL) and instrumental activities of daily living (IADL). Assessment was realized at diagnosis and then three times during the patient’s follow-up. Results: AML and its treatment didn’t impact cognitive (p=0.554) or functional status (p=0.842 for ADL and p=0.087 for IADL). AML ad a positive impact on nutritional status with improvement over time (p=0.041). The benefit was greatest for patients with poor performance status at diagnosis (p<0.001). Conclusion: Our study showed no negative impact of either the experimental or control treatment on cognitive, functional and nutritional status of patients over 60 included in the trial.
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Master Thesis
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Submitted on : Monday, May 3, 2021 - 4:41:16 PM
Last modification on : Wednesday, May 5, 2021 - 3:23:33 AM
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  • HAL Id : dumas-03216022, version 1
  • PPN : 243794843


Claire Jouzier. Conventional chemotherapy for AML in older adults: impact on nutritional, cognitive and functional status. Human health and pathology. 2020. ⟨dumas-03216022⟩



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