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Master Thesis

L’épigénétique comme support d’innovation thérapeutique : exemple d’une étude d’association entre méthylation de l’ADN et taux d’immunoglobulines E totales chez des adultes asthmatiques

Abstract : Epigenetics represents a growing field of research. Although the first epidrugs are marketed in oncology, research is needed for most chronic diseases to identify epigenetic modifications associated with these diseases, constituting potential therapeutic targets. Asthma is a multifactorial disease characterized by a strong phenotypic heterogeneity; allergy, whose the main mediator is the immunoglobulin E (IgE), represents a major component of this heterogeneity. Identification of epigenetic marks associated with total IgE levels in asthmatics may bring further insight into the heterogeneity of this disease. An epigenome-wide association study of total IgE levels was conducted in 357 adults with asthma from the EGEA cohort; replication of the identified sites and regions was investigated in the MRCE cohort and a meta-analysis was conducted. A total of 15 genomic regions and 317 CpG sites have been identified, some of which are close to genes that are particularly relevant in the pathophysiology of asthma and allergy, such as IL-17RA and ICOSLG. These results pave the way for new therapeutic approaches in allergic asthma, especially via coupling of epidrugs to monoclonal antibodies specific for IL-17RA and ICOSLG (brodalumab and prezalumab, respectively), constituting an approach likely to improve selectivity, efficiency and tolerance of these epidrugs. Although further studies are needed, epigenetics raises many hopes and could be a source of therapeutic innovation.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03266141
Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Wednesday, June 30, 2021 - 2:06:53 PM
Last modification on : Friday, July 2, 2021 - 3:28:37 AM
Long-term archiving on: : Friday, October 1, 2021 - 6:03:04 PM

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  • HAL Id : dumas-03266141, version 1

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Laura Beaumier. L’épigénétique comme support d’innovation thérapeutique : exemple d’une étude d’association entre méthylation de l’ADN et taux d’immunoglobulines E totales chez des adultes asthmatiques. Médecine humaine et pathologie. 2019. ⟨dumas-03266141⟩

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