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Master Thesis

Facteurs associés au surpoids dans la cohorte DiaBEA d’enfants diabétiques de type 1

Abstract : Objective: increased weight gain has been reported as a factor that could lead to greater HbA1c for children that suffer Type 1 Diabetes, thus higher risk of long-term complications. Paediatric studies are complicated by age and gender-dependency of BMI, and also by an increasing obesity amongst the general paediatric population. The aim of this study was to evaluate retrospectively the influence of weight gain on the diabetes control in a cohort of children followed in the CHU of Bordeaux, and to assess which factors could lead to overweight through the course of Type 1 Diabetes. Design: data was recorded within the DiaBEA database, a standardised and computer-based documentation follow-up of 126 children affected by Type 1 Diabetes, in the CHU of Bordeaux, over the course of 5 years. Anthropometric data, and HbA1C were recorded during the follow up. Association between weight gain, BMI and HbA1c were assessed. Results: participants had a weight gain and BMIz- gain during the 5 years follow-up, and overall greater BMI-z 5 years after the diabetes diagnostic and intensive care. After stratification by BMI-z gain or by BMI-z, no difference was found over the HbA1c.We found a relation between excessive weight gain and puberty status, and between weight gain and treatment by insulin pump. Conclusions: although there is evidence amongst the recent literature of a link between obesity and greater HbA1c, our study did not show any difference. Our study found out that overweight children were more often treated with pump administration, and that starting puberty was associated with a greater weight gain through the course of Diabetes. We suggest not to overlook the risk of excessive weight gain and increased BMI in children affected with diabetes, and that a larger cohort of french diabetic children should be scanned.
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Submitted on : Tuesday, July 6, 2021 - 11:51:09 AM
Last modification on : Friday, July 9, 2021 - 3:48:02 AM
Long-term archiving on: : Thursday, October 7, 2021 - 6:30:41 PM


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  • HAL Id : dumas-03279135, version 1



Anthony Bousquet. Facteurs associés au surpoids dans la cohorte DiaBEA d’enfants diabétiques de type 1. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03279135⟩



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