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Master Thesis

Lien entre apathie et olfaction dans la maladie de Parkinson

Abstract : The modification of olfactory performance is nowadays one of the precursor sensory symptoms of Parkinson's disease. It is also known that olfaction and apathy have common neural substrates. Thus, we wondered about the effects of apathy on olfaction in patients with Parkinson's disease. Our main objective was to compare the olfactory performance of an apathetic and a non apathetic patient with Parkinson's disease using an odor detection and identification test. Both patients were male and aged 86 and 79 years, respectively. The secondary objective was to study, in the apathetic patient, the effects of the hedonic valence of odors on their identification. Our results show that the non-apathetic patient has better olfactory scores than the apathetic patient (composite score of odor identification and detection at 8/24 versus 4/24 and odor identification score at 3/6 versus 1/6). Nevertheless, the apathetic patient has a lower and therefore better detection threshold than the non-apathetic patient (1 vs. 1.5). Moreover, pleasant odors (hedonic valence score between 6/10 and 10/10), and unpleasant odors (hedonic valence score between 0/10 and 4/10) are not identified by the apathetic patient. However, one neutral odor (hedonic valence score equal to 5/10) out of the two in total, could be identified by the apathetic patient. These results underline the link between olfaction and apathy in Parkinson's disease, and encourage us to take into account olfactory performance in both the assessment and the management of apathy.
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Master Thesis
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Contributor : Bibliothèque Universitaire de Médecine Nice Connect in order to contact the contributor
Submitted on : Tuesday, July 13, 2021 - 10:04:19 AM
Last modification on : Tuesday, December 7, 2021 - 4:10:58 PM


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  • HAL Id : dumas-03285108, version 1


Manon Girard. Lien entre apathie et olfaction dans la maladie de Parkinson. Médecine humaine et pathologie. 2021. ⟨dumas-03285108⟩



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