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Master Thesis

Sickle cell maculopathy: microvascular analysis in OCTA and identification of genetic, systemic and biological risk factors

Abstract : Purpose: To identify genetic, systemic and biological factors associated with the occurrence of sickle cell maculopathy (SCM). To evaluate microvascular macular alterations using optical coherence tomography angiography (OCTA) in sickle cell disease (SCD). Design: Cross-sectional study. Methods: One hundred fifty-one eyes of 78 adult SCD patients (43 HbSS, 30 HbSC, 4 HbS/β+ and 1 HbSLepore) and 40 eyes of 20 healthy controls underwent spectral domain optical coherence tomography (SD-OCT) and OCTA using Spectralis. We analyzed the occurrence of SCM, the foveal avascular zone (FAZ) area and the severity of macular ischemia and studied their relationships with genetic, systemic and biological parameters using multivariate logistic regression analysis. Results: Maculopathy occurred in 66 eyes (44%), and more frequently in HbSS patients (71%, p = 0.004). Multivariate analysis identified HbSS genotype and lower prothrombin ratio (PR) as independently associated with SCM (p = 0.01). Proliferative sickle cell retinopathy was also associated with SCM (p = 0.02). FAZ enlargement was associated with higher lactate dehydrogenase level (p = 0.02). Macular ischemia was more severe in patients with lower hemoglobin level (p = 0.004) and lower PR (p = 0.01). No flow areas were identified with OCTA even in eyes with no macular thinning (36 eyes, 42%) and appeared more frequently in the temporal superior subfield (36%). Conclusions: HbSS genotype, abnormal coagulation and hemolysis increase the risk of SCM. OCTA provides valuable criteria to identify potential risk factors of SCM. OCTA also improves detection of early microvascular changes before the onset of macular thinning.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03286078
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Submitted on : Tuesday, July 13, 2021 - 6:32:44 PM
Last modification on : Tuesday, February 8, 2022 - 2:14:44 PM

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Sélim Fares. Sickle cell maculopathy: microvascular analysis in OCTA and identification of genetic, systemic and biological risk factors. Sensory Organs. 2020. ⟨dumas-03286078⟩

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