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Master Thesis

Étude rétrospective de l’infection au virus Zika en 2016 dans les zones isolées de Guyane

Abstract : Introduction. - The objective of the study was to describe the incidence, socio-demographic and medical characteristics of Zika infection during the 2016 epidemic in isolated health centers in French Guiana. Materials and methods. - In this multicenter retrospective study, all patients followed in health centers with confirmed Zika virus infection (RT-PCR and / or positive IgM serology) were included from January 2016 to June 2017. Two groups were constituted: symptomatic patients and pregnant women. Results. - The geographical distribution of the epidemic was heterogeneous. In the symptomatic group (127 patients, 83 women, mean age: 31.1 years [SD = 1.418]), 74% exhibited rash, 55.9% fever, and 50.4% pruritus. Only 0.8% (1/127) were hospitalized. Patients over 35 had more clinical signs (p = 0.018). Arthralgia, myalgia and asthenia increased with age (p = 0.002, p = 0.009 and p = 0.003, respectively). The average consultation time of 2 days was increased in the absence of social security (+ 50%). No pregnancy test or contraception was prescribed. Less than 50% of patients were screened for another infectious disease, including 8% for HIV. The cumulative incidence in pregnant women in 2016 was on average 11%. Among pregnant women (mean age 25.8 years [SD = 7.170]), 20% (15/76) did not have social security. Only 10.2% (13/127) were symptomatic. They benefited from 2.9 ultrasounds on average and 13% (17/127) showed ultrasound abnormalities. There was 0.8% (1/127) Congenital Zika Syndrome and 3.1% (4/127) isolated microcephaly. Conclusion. - The clinical expression of ZIKV is variable according to sex and age. Fetal complications are comparable to other series. The screening and monitoring of pregnant women is not in line with the recommendations, it has to be improved in the future in isolated health structures.
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Master Thesis
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Submitted on : Monday, July 26, 2021 - 5:02:20 PM
Last modification on : Tuesday, February 8, 2022 - 1:57:17 PM


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Cathy Fauconnet. Étude rétrospective de l’infection au virus Zika en 2016 dans les zones isolées de Guyane. Médecine humaine et pathologie. 2019. ⟨dumas-03299851⟩



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