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Master Thesis

Intérêt de la VE-cadherine soluble en tant que marqueur de dysfonction endothéliale dans le syndrome coronaire chronique

Abstract : Background: Endothelial dysfunction (ED) is implicated in the process of atherogenesis. VE-cadherin is a specific component of adherens junctions attaching vascular endothelial cells together and to the cytoskeleton. Soluble VE-cadherin (sVE-cad) level, the result from the ectodomain shedding in the circulation, has been linked to vascular damage in various diseases. Aim: Evaluate sVE-cad as a marker of ED in the field of chronic coronary syndromes (CCS). Methods: This prospective exploratory study included 33 patients addressed for coronary angiography. Macroscopic evaluation of the coronary tree in angiography (Gensini score) and functional assessment of microcirculation using a pressure – temperature guide wire (coronary flow reserve (CFR) and index of microvascular resistance (IMR)) or TIMI frame count (TFC) were achieved. Blood samples for sVE-cad quantitative dosage using ELISA were available for all patients, and for 96 blood donors. Results : Mean sVE-cad level is significantly higher in the study group compared to the control group (1201.7 ± 305.2 ng/ml vs 730.9 ± 181.8 ng/ml, p < 0.001). sVE-cad level wasn’t associated with the severity of atherosclerotic burden evaluated by Gensini score (r=-0.25, p=0.16). No correlation was found between sVE-cad and TFC (r=-0.023, p=0.9), CFR (r=-0.33, p=0.22) or the IMR (r=0.15, p=0.57). Conclusion: sVE-cad level, used as a specific and easily available biomarker of ED, is increased in CCS. However, it did not correlate with the usual parameters assessing atherosclerotic stenosis severity and microvascular dysfunction.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03332460
Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Thursday, September 30, 2021 - 9:54:15 AM
Last modification on : Wednesday, November 3, 2021 - 7:05:35 AM
Long-term archiving on: : Friday, December 31, 2021 - 6:02:16 PM

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  • HAL Id : dumas-03332460, version 1

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Lucie Mantes. Intérêt de la VE-cadherine soluble en tant que marqueur de dysfonction endothéliale dans le syndrome coronaire chronique. Human health and pathology. 2020. ⟨dumas-03332460⟩

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