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Master Thesis

Impact des adaptations mécaniques et immunologiques liées à la grossesse chez les patientes porteuses de spondyloarthrites

Abstract : Spondylarthropathies (SpA) are the second most common inflammatory rheumatic disease and affects patients of childbearing age. The non-radiological forms predominating in women highlight the problem of managing pregnancy in this dysimmune field. Firstly, we conducted a systematic analysis of the literature, which revealed a tendency for pregnancy or post-partum to have no impact on the activity of the rheumatism and raised the question of the definition of the disease flare-up in this particular context. Second, we conducted a meta-analysis to compare the prevalence of neonatal and maternal complications in patients with SpA versus control patients. 12 controlled studies were included in the meta-analysis, gathering 7300 SpA patients. An increased risk of pre-eclampsia (OR 1.39 95%CI [1.11; 1.75]), caesarean delivery (OR 1.52 95%CI [1.28; 1.80]), and in particular scheduled caesarean delivery (OR 1.62 95%CI [1.29, 2.03]), and preterm birth (OR 1.51 CI 95% [1.36, 1.67]) were found. No increase in the risk of neonatal complications was found. An implication of immune system abnormalities could be suggested in the increased risk of pre-eclampsia and preterm birth. The question of the increased use of cesarean section should be considered in conjunction with gynecologists-obstetricians.
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Master Thesis
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Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Thursday, September 9, 2021 - 10:21:52 AM
Last modification on : Sunday, September 12, 2021 - 3:16:24 AM


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  • HAL Id : dumas-03338885, version 1


Chloé Bernardy. Impact des adaptations mécaniques et immunologiques liées à la grossesse chez les patientes porteuses de spondyloarthrites. Médecine humaine et pathologie. 2021. ⟨dumas-03338885⟩



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