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Master Thesis

Apport du cliché de tomosynthèse en compression localisée pour la caractérisation des images indéterminées en tomosynthèse

Abstract : Objective: to evaluate whether digital breast tomosynthesis (DBT) spot compression view (SCV) can improve evaluation of equivocal findings on DBT. Materials and methods: institutional review board approval was obtained for this retrospective study and informed consent was waived. Three breast radiologists with different levels of experience in DBT reading reviewed images of 102 patients who underwent DBT-SCV for an equivocal finding on DBT between December 2018 and December 2019. One reader reviewed examinations twice for intra-reader agreement evaluation. Lesions were rated according to their likelihood of malignancy (5-point scale) and according to BI-RADS (Breast Imaging Reporting And Data System) classification on DBT alone and with the adjunct of DBT-SCV. Intra- and Inter-reader agreement were evaluated using Weighted-Kappa. Reader performance according to BI-RADS classification with and without DBT-SCV were compared using McNemar test. Diagnostic accuracy using likelihood of malignancy was evaluated by calculating the area under the receiver operating characteristics curve (AUROC). Results were compared with histopathological results or with one year follow-up. Results: intra- and inter-reader agreement were fair or moderate on DBT and good with the adjunct of DBT-SCV. With DBT-SCV, performances according to BI-RADS classification were improved for all readers (P<0.0001). In particular, specificity was increased for all readers (69%, 75%, and 68% on DBT and 90%, 94% and 93% with DBT-SCV for readers 1, 2 and 3 respectively). Diagnostic accuracy for the evaluation of the likelihood of malignancy was variable among the readers on DBT (P=0.02) but no such a difference was observed with DBT-SCV (P=0.2). Supplemental radiation dose of DBT-SCV was 1.97mGy versus 1.78 and 1.81 mGy for standard DBT CC and MLO view. Conclusion: DBT-SCV may improve inter-reader agreement and diagnostic accuracy for the assessment of equivocal findings on DBT with a supplemental dose only slightly higher than one standard DBT view.
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Submitted on : Thursday, September 23, 2021 - 1:20:10 PM
Last modification on : Friday, October 22, 2021 - 3:44:42 AM
Long-term archiving on: : Friday, December 24, 2021 - 8:46:40 PM


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  • HAL Id : dumas-03352643, version 1



Florian Deleau. Apport du cliché de tomosynthèse en compression localisée pour la caractérisation des images indéterminées en tomosynthèse. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03352643⟩



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